Effects of Obesity on Substrate Utilization during Exercise
Open accessAbstract
Objective: The capacity for lipid and carbohydrate (CHO) oxidation during exercise is important for energy partitioning and storage. This study examined the effects of obesity on lipid and CHO oxidation during exercise. Research Methods and Procedures: Seven obese and seven lean [body mass index (BMI), 33 ± 0.8 and 23.7 ± 1.2 kg/m 2 , respectively] sedentary, middle‐aged men matched for aerobic capacity performed 60 minutes of cycle exercise at similar relative (50% V o 2max ) and absolute exercise intensities. Results: Obese men derived a greater proportion of their energy from fatty‐acid oxidation than lean men (43 ± 5% 31 ± 2%; p = 0.02). Plasma fatty‐acid oxidation determined from recovery of infused [0.15 μmol/kg fat‐free mass (FFM) per minute] [1‐ 13 C]‐palmitate in breath CO 2 was similar for obese and lean men (8.4 ± 1.1 and 29 ± 15 μmol/kg FFM per minute). Nonplasma fatty‐acid oxidation, presumably, from intramuscular sources, was 50% higher in obese men than in lean men (10.0 ± 0.6 versus 6.6 ± 0.8 μmol/kg FFM per minute; p < 0.05). Systemic glucose disposal was similar in lean and obese groups (33 ± 8 and 29 ± 15 μmol/kg FFM per minute). However, the estimated rate of glycogen‐oxidation was 50% lower in obese than in lean men (61 ± 12 versus 90 ± 6 μmol/kg FFM per minute; p < 0.05). Discussion: During moderate exercise, obese sedentary men have increased rates of fatty‐acid oxidation from nonplasma sources and reduced rates of CHO oxidation, particularly muscle glycogen, compared with lean sedentary men.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lipid oxidation during exercise was higher in obese/insulin-resistant than lean subjects.
“On the other hand, lipid oxidation during exercise was higher in obese/insulin-resistant vs. lean subjects (14,16).”
From Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity (2018) · cites this paper as [14]
Cites
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works
Calculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365 · see citing works
Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E., & Wolfe, R. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e380 · Cited by 1,747 · see citing works
Self-citationINFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Wei, M. (1999) · JAMA · doi:10.1001/jama.282.16.1547 · Cited by 1,168 · see citing works
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works
Self-citationFlier, J. S., Underhill, L. H., & Eckel, R. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904203201607 · Cited by 973 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Hjemdahl, P., Daleskog, M., & Kahan, T. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90384-9 · Cited by 574 · see citing works
Intramuscular lipid content is increased in obesity and decreased by weight loss
Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80010-4 · Cited by 526 · see citing works
Self-citationMuscle triglyceride utilization during exercise: effect of training
Hurley, B. F., Nemeth, P. M., Martin, W. H., Hagberg, J. M., Dalsky, G. P., & Holloszy, J. O. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.562 · Cited by 522 · see citing works
Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491 · see citing works
Self-citationImpaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487 · see citing works
Self-citationRadioactive and Stable Isotope Tracers in Biomedicine
Bramlet, R. C. (1993) · Clinical Nuclear Medicine · doi:10.1097/00003072-199305000-00027 · Cited by 396 · see citing works
Phillips, D. I. W., Caddy, S., Ilic, V., Fielding, B. A., Frayn, K. N., Borthwick, A. C., & Taylor, R. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90260-7 · Cited by 390 · see citing works
Correlation between muscle glycogen synthase activity and in vivo insulin action in man
Bogardus, C., Lillioja, S., Stone, K., & Mott, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111304 · Cited by 335 · see citing works
Sherman, W., Costill, D., Fink, W., & Miller, J. (1981) · International Journal of Sports Medicine · doi:10.1055/s-2008-1034594 · Cited by 325 · see citing works
Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise
Coyle, E. F., Jeukendrup, A. E., Wagenmakers, A. J. M., & Saris, W. H. M. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.2.e268 · Cited by 292 · see citing works
Muscle fibre type and aetiology of obesity
Wade, A. J., Marbut, M. M., & Round, J. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)90933-v · Cited by 245 · see citing works
Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise
Martin, W. H., Dalsky, G. P., Hurley, B. F., Matthews, D. E., Bier, D. M., Hagberg, J. M., Rogers, M. A., King, D. S., & Holloszy, J. O. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.5.e708 · Cited by 236 · see citing works
Kelley, D. E., Mintun, M. A., Watkins, S. C., Simoneau, J. A., Jadali, F., Fredrickson, A., Beattie, J., & Thériault, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118724 · Cited by 228 · see citing works
Self-citationA new correction factor for use in tracer estimations of plasma fatty acid oxidation
Sidossis, L. S., Coggan, A. R., Gastaldelli, A., & Wolfe, R. R. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.4.e649 · Cited by 189 · see citing works
Self-citationEffects of exercise intensity and training on lipid metabolism in young women.
Friedlander, A., Casazza, G., Horning, M., Buddinger, T. F., & Brooks, G. (1998) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e853 · Cited by 182 · see citing works
Blaak, E. E., van Aggel-Leijssen, D. P., Wagenmakers, A. J., Saris, W. H., & van Baak, M. A. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2102 · Cited by 178 · see citing works
Jeukendrup, A. E., Raben, A., Gijsen, A. P., Stegen, J. H. C. H., Brouns, F. J. P. H., Saris, W. H. M., & Wagenmakers, A. J. M. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.579ac.x · Cited by 176 · see citing works
Effect of training status on fuel selection during submaximal exercise with glucose ingestion
van Loon, L. J. C., Jeukendrup, A. E., Saris, W. H. M., & Wagenmakers, A. J. M. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1413 · Cited by 108 · see citing works
Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies.
Sidossis, L. S., Coggan, A. R., Gastaldelli, A., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117652 · Cited by 86 · see citing works
Self-citationOxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity
Horowitz, J. F., & Klein, S. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2276 · Cited by 85 · see citing works
Colberg, S. R., Hagberg, J. M., McCole, S. D., Zmuda, J. M., Thompson, P. D., & Kelley, D. E. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2027 · Cited by 85 · see citing works
Self-citationRole of glycogen-lowering exercise in the change of fat oxidation in response to a high-fat diet.
Schrauwen, P., Lichtenbelt, W. D. V. M., Saris, W. H. M., & Westerterp, K. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.3.e623 · Cited by 77 · see citing works
Regulation of fatty acid oxidation in untrained vs. trained men during exercise
Sidossis, L. S., Wolfe, R. R., & Coggan, A. R. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e510 · Cited by 76 · see citing works
Self-citationMuscle triglycerides in diabetic subjects
Standl, E., Lotz, N., Dexel, T., Janka, H. U., & Kolb, H. J. (1980) · Diabetologia · doi:10.1007/bf00261702 · Cited by 69 · see citing works
Giacca, A., Groenewoud, Y., Tsui, E. Y. L., Mcclean, P. A., & Zinman, B. (1998) · Diabetes · doi:10.2337/diabetes.47.11.1763 · Cited by 69 · see citing works
Schrauwen, P., van Aggel-Leijssen, D. P. V., Lichtenbelt, W. D. V. M., van Baak, M. V., Gijsen, A., & Wagenmakers, A. (1998) · Journal of Physiology · doi:10.1111/j.1469-7793.1998.215by.x · Cited by 64 · see citing works
Intramuscular fatty acid metabolism evaluated with stable isotopic tracers
Guo, Z., & Jensen, M. D. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1674 · Cited by 63 · see citing works
Hormone-Sensitive Lipase (HSL) Expression and Regulation in Skeletal Muscle
Langfort, J., Ploug, T., Ihlemann, J., Enevoldsen, L. H., Stallknecht, B. M., Saldo, M., Kjær, M., Holm, C., & Galbo, H. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1928-1_20 · Cited by 59 · see citing works
Cline, G. W., Magnusson, I., Rothman, D. L., Petersen, K. F., Laurent, D., & Shulman, G. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119395 · Cited by 50 · see citing works
Pagliassotti, M. J., Pan, D. A., Prach, P. A., Koppenhafer, T. A., Storlien, L., & Hill, J. O. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00175.x · Cited by 47 · see citing works
Skeletal Muscle Metabolism in Exercise and Diabetes
Richter, E. A., Kiens, B., Galbo, H., & Saltin, B. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1928-1 · Cited by 42 · see citing works
Fatness in relation to substrate oxidation during exercise.
Bj, G., Ms, A., Pr, M., Gr, G., Harding, M., & Prentice, A. M. (1994) · PubMed · Cited by 28 · see citing works
Ravussin, É., Pahud, P., Thelin-Doerner, A., Arnaud, M., & Jéquier, E. (1980) · PubMed · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Metabolic Flexibility in Health and Disease
Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995 · see citing works
Self-citationExercise training‐induced improvements in insulin action
Hawley, J. A., & Lessard, S. J. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01783.x · Cited by 454 · see citing works
Goodpaster, B. H., Katsiaras, A., & Kelley, D. E. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2191 · Cited by 390 · see citing works
Self-citationCrosignani, P. G. (2003) · Human Reproduction · doi:10.1093/humrep/deg367 · Cited by 359 · see citing works
Freedland, E. S. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-12 · Cited by 296 · see citing works
Use of intramuscular triacylglycerol as a substrate source during exercise in humans
van Loon, L. J. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00368.2004 · Cited by 205 · see citing works
Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity
Moro, C., Bajpeyi, S., & Smith, S. R. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00624.2007 · Cited by 179 · see citing works
Wang, Y., Mohsen, A.-W. A., Mihalik, S. J., Goetzman, E. S., & Vockley, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139493 · Cited by 169 · see citing works
Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research
Kim, I.-Y., Suh, S., Lee, I., & Wolfe, R. R. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.97 · Cited by 164 · see citing works
Self-citationInsulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works
Whole-body protein anabolic response is resistant to the action of insulin in obese women
Chevalier, S., Marliss, E. B., Morais, J. A., Lamarche, M., & Gougeon, R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.355 · Cited by 137 · see citing works
Ramos‐Jiménez, A., Hernández‐Torres, R. P., Torres-Durán, P. V., Romero-González, J., Mascher, D., Posadas‐Romero, C., & Juárez-Oropeza, M. A. (2008) · Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine · doi:10.4137/ccrpm.s449 · Cited by 135 · see citing works
Moghetti, P., Bacchi, E., Brangani, C., Donà, S., & Negri, C. (2016) · Frontiers of hormone research · doi:10.1159/000445156 · Cited by 133 · see citing works
Impaired plasma fatty acid oxidation in extremely obese women
Thyfault, J. P., Kraus, R. M., Hickner, R. C., Howell, A. W., Wolfe, R. R., & Dohm, G. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00177.2004 · Cited by 122 · see citing works
Self-citationYouth Athlete Development and Nutrition
Desbrow, B. (2021) · Sports Medicine · doi:10.1007/s40279-021-01534-6 · Cited by 114 · see citing works
“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
Holloszy, J. O. (2013) · Diabetes · doi:10.2337/db12-1107 · Cited by 111 · see citing works
Sczelecki, S., Besse-Patin, A., Abboud, A., Kleiner, S., Laznik-Bogoslavski, D., Wrann, C. D., Ruas, J. L., Haibe-Kains, B., & Estall, J. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00578.2013 · Cited by 108 · see citing works
Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking
Bergouignan, A., Trudel, G., Simon, C., Chopard, A., Schoeller, D. A., Momken, I., Votruba, S. B., Desage, M., Burdge, G. C., Gauquelin‐Koch, G., et al. (2008) · Diabetes · doi:10.2337/db08-0263 · Cited by 107 · see citing works
Amati, F., Dubé, J. J., Shay, C., & Goodpaster, B. H. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90384.2008 · Cited by 89 · see citing works
Self-citationHarnessing Muscle–Liver Crosstalk to Treat Nonalcoholic Steatohepatitis
Chakravarthy, M. V., Siddiqui, M. S., Forsgren, M. F., & Sanyal, A. J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.592373 · Cited by 89 · see citing works
Ara, I., Larsen, S., Stallknecht, B. M., Guerra, B., Morales‐Álamo, D., Andersen, J. L., Ponce‐González, J. G., Guadalupe‐Grau, A., Galbo, H., Calbet, J. A. L., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.123 · Cited by 88 · see citing works
Riddell, M. C., Jamnik, V., Iscoe, K. E., Timmons, B. W., & Gledhill, N. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01256.2007 · Cited by 84 · see citing works
Exercise and the Treatment of Diabetes and Obesity
O’Gorman, D. J., & Krook, A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.07.006 · Cited by 85 · see citing works
Effects of insulin resistance on substrate utilization during exercise in overweight women
Braun, B., Sharoff, C., Chipkin, S. R., & Beaudoin, F. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00231.2004 · Cited by 84 · see citing works
Dubé, J. J., Coen, P. M., DiStefano, G., Chacon, A. C., Helbling, N. L., Desimone, M. E., Stafanovic-Racic, M., Hames, K. C., Despines, A. A., Toledo, F. G. S., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2014 · Cited by 83 · see citing works
Self-citationImpact of metformin on peak aerobic capacity
Braun, B., Eze, P. N., Stephens, B. R., Hagobian, T. A., Sharoff, C. G., Chipkin, S. R., & Goldstein, B. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-144 · Cited by 82 · see citing works
Devries, M. C., Samjoo, I. A., Hamadeh, M. J., McCready, C., Raha, S., Watt, M. J., Steinberg, G. R., & Tarnopolsky, M. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2044 · Cited by 82 · see citing works
Rosenkilde, M., Nordby, P., Nielsen, L., Stallknecht, B., & Helge, J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.11 · Cited by 79 · see citing works
ATAKAN, M. M., Güzel, Y., Shrestha, N., Koşar, Ş. N., Grgić, J., Astorino, T. A., Turnagöl, H. H., & Pedišić, Ž. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-105181 · Cited by 86 · see citing works
Reljic, D., Frenk, F., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-82372-4 · Cited by 70 · see citing works
Mittendorfer, B., Fields, D. A., & Klein, S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2003 · Cited by 70 · see citing works
DiMenna, F. J., & Arad, A. D. (2018) · BMC Sports Science, Medicine and Rehabilitation · doi:10.1186/s13102-018-0110-8 · Cited by 68 · see citing works
Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67 · see citing works
Reljic, D., Frenk, F., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02592-6 · Cited by 71 · see citing works
Hansen, D., MEEUSEN, R. R., Mullens, A., & Dendale, P. (2012) · Sports Medicine · doi:10.2165/11599590-000000000-00000 · Cited by 65 · see citing works
Ounis, O. B., Elloumi, M., Chiekh, I. B., Zbidi, A., Amri, M., Lac, G., & Tabka, Z. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.05.011 · Cited by 65 · see citing works
Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome
Whigham, L. D., Bütz, D. E., Dashti, H., Tonelli, M., Johnson, L. K., Cook, M. E., Porter, W. P., Eghbalnia, H. R., Markley, J. L., Lindheim, S. R., et al. (2014) · Current Metabolomics · doi:10.2174/2213235x01666131203230512 · Cited by 65 · see citing works
Physical activity: An effective way to control weight in children?
Maffeis, C., & Castellani, M. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.08.006 · Cited by 54 · see citing works
Childhood obesity and walking: guidelines and challenges
Shultz, S. P., Browning, R. C., Schütz, Y., Maffeis, C., & Hills, A. P. (2011) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2011.590202 · Cited by 53 · see citing works
Lanzi, S., Codecasa, F., Cornacchia, M., Maestrini, S., Salvadori, A., Brunani, A., & Malatesta, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088707 · Cited by 50 · see citing works
Optimizing fat oxidation through exercise in severely obese Caucasian adolescents
Lazzer, S., Busti, C., Agosti, F., Col, A. D., Pozzo, R., & Sartório, A. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02929.x · Cited by 50 · see citing works
Relationships between Obesity, Cardiorespiratory Fitness, and Cardiovascular Function
Davison, K., Bircher, S., Hill, A. M., Coates, A. M., Howe, P. R. C., & Buckley, J. D. (2010) · Journal of Obesity · doi:10.1155/2010/191253 · Cited by 50 · see citing works
Nutrient Oxidation during Moderately Intense Exercise in Obese Prepubertal Boys
Maffeis, C., Zaffanello, M., Pellegrino, M., Banzato, C., Bogoni, G., Viviani, E., Ferrari, M., & Tatò, L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0715 · Cited by 50 · see citing works
Prior, S. J., Ryan, A. S., Stevenson, T. G., & Goldberg, A. P. (2013) · Obesity · doi:10.1002/oby.20609 · Cited by 47 · see citing works
Factors Influencing Substrate Oxidation During Submaximal Cycling: A Modelling Analysis
Rothschild, J. A., Kilding, A. E., Stewart, T., & Plews, D. J. (2022) · Sports Medicine · doi:10.1007/s40279-022-01727-7 · Cited by 46 · see citing works
Hernández-Lepe, M. A., Wall‐Medrano, A., López‐Díaz, J. A., Juárez-Oropeza, M. A., Luqueño-Bocardo, O. I., Hernández‐Torres, R. P., & Ramos‐Jiménez, A. (2019) · Marine Drugs · doi:10.3390/md17050270 · Cited by 46 · see citing works
Trafficking of dietary fat and resistance to obesity
Bessesen, D. H., Bull, S., & Cornier, M. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.019 · Cited by 43 · see citing works
Metabolic flexibility and obesity in children and youth
Aucouturier, J., Duché, P., & Timmons, B. W. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00812.x · Cited by 43 · see citing works
Shoemaker, M. E., Pereira, S. L., Mustad, V. A., Gillen, Z. M., McKay, B. D., Lopez‐Pedrosa, J. M., Rueda, R., & Cramer, J. T. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12932 · Cited by 43 · see citing works
Exercise and the Treatment of Diabetes and Obesity
O’Gorman, D. J., & Krook, A. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.007 · Cited by 42 · see citing works
Muscle Characteristics and Substrate Energetics in Lifelong Endurance Athletes
Dubé, J. J., Broskey, N. T., Despines, A. A., Stefanović-Račić, M., Toledo, F. G. S., Goodpaster, B. H., & Amati, F. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000789 · Cited by 42 · see citing works
Self-citationInsulin‐ and Exercise‐Stimulated Skeletal Muscle Blood Flow and Glucose Uptake in Obese Men
Hällsten, K., Yki‐Järvinen, H., Peltoniemi, P., Oikonen, V., Takala, T., Kemppainen, J., Laine, H. K., Bergman, J. R., Bolli, G. B., Knuuti, J. M., et al. (2003) · Obesity Research · doi:10.1038/oby.2003.39 · Cited by 42 · see citing works
Mazzatti, D. J., Smith, M. A., Oita, R. C., Lim, F.-L., White, A., & Reid, M. B. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00281.2007 · Cited by 41 · see citing works
Lefai, É., Blanc, S., Momken, I., Antoun, E., Chery, I., Zahariev, A., Gabert, L., Bergouignan, A., & Simon, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.151 · Cited by 38 · see citing works
Effect of metformin on exercise capacity: A meta-analysis
Das, S., Behera, S. K., Srinivasan, A., Xavier, A. S., Selvarajan, S., Kamalanathan, S., Sahoo, J. P., & Nair, N. S. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.08.022 · Cited by 37 · see citing works
Aucouturier, J., Rance, M., Meyer, M., Isacco, L., Thivel, D., Fellmann, N., Duclos, M., & Duché, P. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0907-3 · Cited by 36 · see citing works
Malin, S. K., Liu, Z., Barrett, E. J., & WELTMAN, A. L. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9352-5 · Cited by 34 · see citing works
Fernández-Verdejo, R., Bajpeyi, S., Ravussin, E., & Galgani, J. E. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00126.2018 · Cited by 34 · see citing works
Steinbacher, P., Feichtinger, R. G., Kedenko, L., Kedenko, I., Reinhardt, S., Schönauer, A.-L., Leitner, I., Sänger, A. M., Stoiber, W., Kofler, B., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123881 · Cited by 33 · see citing works
Cardiorespiratory Fitness May Influence Metabolic Inflexibility During Exercise in Obese Persons
Amaro‐Gahete, F. J., Sánchez‐Delgado, G., Ara, I., & Ruiz, J. R. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01225 · Cited by 31 · see citing works
Influence of maximal fat oxidation on long-term weight loss maintenance in humans
Dandanell, S., Husted, K., Amdisen, S., Vigelsø, A., Dela, F., Larsen, S., & Helge, J. W. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00270.2017 · Cited by 29 · see citing works
Delgado‐Floody, P., Izquierdo, M., Ramírez‐Vélez, R., Navarrete, F. C., Moris, R., Jerez‐Mayorga, D., Andrade, D. C., & Álvarez, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.558910 · Cited by 29 · see citing works
Reljic, D., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2021) · Nutrients · doi:10.3390/nu13051640 · Cited by 29 · see citing works
Mohebbi, H., & Azizi, M. (2011) · Journal of Human Sport and Exercise · doi:10.4100/jhse.2011.61.06 · Cited by 29 · see citing works
Altered metabolic and hormonal responses to moderate exercise in overweight/obesity
Gar, C., Rottenkolber, M., Haenelt, M., Potzel, A. L., Kern-Matschilles, S., Then, C., Seißler, J., Bidlingmaier, M., & Lechner, A. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154219 · Cited by 27 · see citing works
Current Perspectives: Obesity and Neurodegeneration - Links and Risks
Kueck, P. J., Morris, J. K., & Stanford, J. A. (2024) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s388579 · Cited by 29 · see citing works
Exercise training at the intensity of maximal fat oxidation in obese boys
Tan, S., Wang, J., & Cao, L. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0174 · Cited by 26 · see citing works
Shay, C. M., Carnethon, M. R., Church, T. R., Hankinson, A. L., Chan, C., Jacobs, D. R., Lewis, C. E., Schreiner, P. J., Sternfeld, B., & Sidney, S. (2011) · Obesity · doi:10.1038/oby.2011.113 · Cited by 23 · see citing works
Ispoglou, T., Wilson, O. J., McCullough, D., Aldrich, L., Ferentinos, P. P., Lyall, G. K., Stavropoulos‐Kalinoglou, A., Duckworth, L. C., Brown, M. A., Sutton, L., et al. (2023) · Biology · doi:10.3390/biology12070892 · Cited by 22 · see citing works
Effects of obesity phenotype on fat metabolism in obese men during endurance exercise
Numao, S., Hayashi, Y., Katayama, Y., Matsuo, T., Tomita, T., Ohkawara, K., Nakata, Y., & Tanaka, K. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803282 · Cited by 22 · see citing works
Metabolic profiling of muscle contraction in lean compared with obese rodents
Thyfault, J. P., Cree, M. G., Tapscott, E. B., Bell, J. A., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Dohm, G. L., & Muoio, D. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00093.2010 · Cited by 21 · see citing works
Self-citationNo Influence of Overweight/Obesity on Exercise Lipid Oxidation: A Systematic Review
Arad, A. D., Basile, A. J., Albu, J., & DiMenna, F. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051614 · Cited by 22 · see citing works
Malin, S. K., Remchak, M. E., Smith, A. J., Ragland, T. J., Heiston, E. M., & Cheema, U. (2022) · Experimental Physiology · doi:10.1113/ep090613 · Cited by 19 · see citing works
Tinius, R. A., Cahill, A. G., Strand, E. A., & Cade, W. T. (2016) · Integrative Obesity and Diabetes · doi:10.15761/iod.1000137 · Cited by 20 · see citing works
Malin, S. K., Viskochil, R. H., Oliver, C., & Braun, B. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00084.2013 · Cited by 17 · see citing works
Nilsson, B. M., Olsson, R. M., Öman, A., Wiesel, F. ‐., Ekselius, L., & Forslund, A. H. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.06.007 · Cited by 17 · see citing works
Comparing fat oxidation in an exercise test with moderate-intensity interval training.
Alkahtani, S. A. (2014) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
Role of CaMKII in the regulation of fatty acids and lipid metabolism
Joseph, J. S., Anand, K., Malindisa, S. T., & Fagbohun, O. F. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.02.037 · Cited by 16 · see citing works
Lazzer, S., Molin, M., Stramare, D., Facchini, S., & Francescato, M. P. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346399 · Cited by 16 · see citing works
Altered stress hormone response following acute exercise during prostate cancer treatment
Hanson, E. D., Sakkal, S., Evans, W. S., Violet, J. A., Battaglini, C. L., McConell, G. K., & Hayes, A. (2018) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13199 · Cited by 16 · see citing works
Chávez-Guevara, I. A., Hernández‐Torres, R. P., Trejo-Trejo, M., González-Rodríguez, E., Moreno-Brito, V., Wall‐Medrano, A., Pérez-León, J. A., & Ramos‐Jiménez, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136945 · Cited by 16 · see citing works
Quantifications of Lipid KineticsIn VivoUsing Stable Isotope Tracer Methodology
Kim, I., Park, S., Jang, J., & Wolfe, R. R. (2020) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2020.9.1.110 · Cited by 14 · see citing works
Self-citationBattista, F., Belligoli, A., Neunhäeuserer, D., Gasperetti, A., Bettini, S., Compagnin, C., Marchese, R., Quinto, G., Bergamin, M., Vettor, R., et al. (2021) · Obesity Facts · doi:10.1159/000517589 · Cited by 14 · see citing works
Buerger, A. N., Parente, C. E., Harris, J. P., Watts, E. G., Wormington, A. M., & Bisesi, J. H. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133703 · Cited by 14 · see citing works
Balcı, Ş. S. (2012) · Obesity Facts · doi:10.1159/000339504 · Cited by 14 · see citing works
Obesity and the Role of Short Duration Submaximal Work on Cardiovascular and Cerebral Hemodynamics
Cavuoto, L. A., & Maikala, R. V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153826 · Cited by 14 · see citing works
Frandsen, J., Hansen, I. M. D., Wismann, J., Olsen, M. H., Brage-Andersen, M. R., Sahl, R. E., Hansen, M., Ingersen, A., Modvig, J. L., Schmücker, M., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab473 · Cited by 13 · see citing works
Vanderboom, P. M., Zhang, X., Hart, C. R., Kunz, H., Gries, K. J., Heppelmann, C. J. H., Liu, Y., Dasari, S., & Lanza, I. R. (2022) · Obesity · doi:10.1002/oby.23419 · Cited by 13 · see citing works
Simple Exercise Recovery Index for Sympathetic Overactivity Is Linked to Insulin Resistance
Yeckel, C. W., Gulanski, B., Zgorski, M., DZIURA, J., Parish, R., & Sherwin, R. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818afa2f · Cited by 13 · see citing works
Mittendorfer, B., & Klein, S. (2003) · Nutrition Research Reviews · doi:10.1079/nrr200357 · Cited by 13 · see citing works
Siddiqui, M. S., Patel, S. S., Forsgren, M. F., Bui, A. T., Shen, S., Syed, T., Boyett, S. L., Chen, S., Sanyal, A. J., Wolver, S. E., et al. (2022) · Liver International · doi:10.1111/liv.15178 · Cited by 12 · see citing works
Löfberg, I. E., Karppinen, J. E., Laatikainen‐Raussi, I., Ihalainen, J. K., Lehti, M., Hackney, A. C., & Taipale, R. S. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003676 · Cited by 11 · see citing works
Rochette, E., Bourdier, P., Pereira, B., Doré, É., Birat, A., Ratel, S., Echaubard, S., Duché, P., & Merlin, É. (2019) · Pediatric Rheumatology · doi:10.1186/s12969-019-0354-1 · Cited by 9 · see citing works
Exogenous glucose oxidation is reduced with carbohydrate feeding during exercise after starvation
ROWLANDS, D. S., Johnson, N. A., Thomson, J. A., Chapman, P., & Stannard, S. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.03.016 · Cited by 9 · see citing works
Muscle Type‐Dependent Responses to Insulin in Intramyocellular Triglyceride Turnover in Obese Rats
Guo, Z., & Zhou, L. (2005) · Obesity Research · doi:10.1038/oby.2005.258 · Cited by 9 · see citing works
van Baak, M. A., & Saris, W. H. M. (2005) · doi:10.1002/9780470987087.ch24 · Cited by 9 · see citing works
Whole-body vibration promotes lipid mobilization in hypothalamic obesity rat
de Andrade, B. Z., Zazula, M. F., Guimarães, A. T. B., Schneider, S. C. S., Boaretto, M. L., Poncio, A. C. F., Maciel, J. I. H. N., de Oliveira, C. M. T., Brancalhão, R. M. C., Bertolini, G. R. F., et al. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101456 · Cited by 8 · see citing works
High-intensity interval exercise in the cold regulates acute and postprandial metabolism
Munten, S., Ménard, L., Gagnon, J., Dorman, S. C., Mezouari, A., & Gagnon, D. D. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00384.2020 · Cited by 8 · see citing works
Effects of Statins on Fat Oxidation Improvements After Aerobic Exercise Training
Álvarez-Jiménez, L., Morales‐Palomo, F., Moreno‐Cabañas, A., ORTEGA, J. F., & Mora‐Rodríguez, R. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac668 · Cited by 9 · see citing works
Intramyocellular lipids: Maker vs. marker of insulin resistance
Guo, Z. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.03.044 · Cited by 8 · see citing works
- Authors
- Goodpaster, B. H., Wolfe, R. R., & Kelley, D. E.
- Affiliations
- University of Pittsburgh (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Goodpaster, Bret H.
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2002-07
- Volume
- 10
- Issue
- 7
- Pages
- 575-584
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2067153601
- Cited by
- 169
- References
- 42
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 18 · 2021: 9 · 2020: 13 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k01ag000851-04, 5p30dk046204-15)
- National Institute on Aging (K01-AG-00851)
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK-46204)
- National Center for Research Resources (M01RR000056, 5 M01 RR 0056)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, substrate utilization, fatty acid oxidation, carbohydrate oxidation, energy allocation, muscle glycogen, glucose disposal, moderate-intensity exercise
- MeSH terms
- Adult, Blood Glucose, Breath Tests, Carbon Isotopes, Energy Metabolism, Fatty Acids, Fatty Acids, Nonesterified, Glycogen, Humans, Insulin, Kinetics, Male, Norepinephrine, Obesity, Oxidation-Reduction, Oxygen Consumption, Exercise, Body Mass Index, Muscle, Skeletal, Palmitic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
