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Cited by 73Thermoregulation and physiological responsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Effects of Dehydration during Cycling on Skeletal Muscle Metabolism in Females

LOGAN-SPRENGER, HEATHER M., HEIGENHAUSER, GEORGE J. F., KILLIAN, KIERAN J., SPRIET, LAWRENCE L.·2012·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0b013e31825abc7c
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Abstract

INTRODUCTION: This study investigated the effects of progressive dehydration on the time course of changes to whole body substrate oxidation and skeletal muscle metabolism during 120 min of cycling in hydrated females. METHODS: Subjects (n = 9) cycled for 120 min at approximately 65% VO(2peak) on two occasions: with no fluid (DEH) and with fluid (HYD) replacement to match sweat losses. Venous blood samples were taken at rest and every 20 min and muscle biopsies taken at 0, 60, and 120 min of exercise. RESULTS: DEH subjects lost 0.9% body mass from 0 to 60 min and 1.1% from 60 to 120 min (2.0% total). HR and core temperature (Tc) were significantly greater from 30 to 120 min, plasma volume (Pvol) loss from 40 to 120 min, and RPE from 60 to 120 min in the DEH trial. There were no differences in VO(2) or sweat loss between trials. RER (HYD, 0.85 ± 0.01, vs. DEH, 0.87 ± 0.01) and total CHO oxidation (175 ± 17 vs. 191 ± 17 g) were higher in the DEH trial. Blood (La) was significantly higher in the DEH trial, with no change in plasma free fatty acid and epinephrine concentrations. Muscle glycogenolysis was 31% greater in the DEH trial (252 ± 49 vs. 330 ± 33 mmol.kg(-1) dry muscle), and muscle (La) was also higher at 60 min. CONCLUSION: Progressive dehydration significantly increased HR, Tc, RPE, Pvol loss, whole body CHO oxidation, and muscle glycogenolysis, and these changes were already apparent in the first hour of exercise when body mass losses were ≤ 1%. The increased muscle glycogenolysis with DEH appeared to be due to increased core and muscle temperature, secondary to less efficient movement of heat from the core to the periphery.

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  • Females have, on average, lower absolute total water volume as compared with males (~31 vs.~44 L) even when expressed as a proportion of body mass (~49% vs. 58%).

    “Females have, on average, lower absolute total water volume as compared with males (~31 vs.~44 L) [270] even when expressed as a proportion of body mass (~49% vs. 58%) [271].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [271]

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Authors
LOGAN-SPRENGER, H. M., HEIGENHAUSER, G. J. F., KILLIAN, K. J., & SPRIET, L. L.
Affiliations
  • University of Guelph (CA)
  • McMaster University (CA)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-10
Volume
44
Issue
10
Pages
1949-1957
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/mss.0b013e31825abc7c
OpenAlex
W2094587672
Cited by
73
References
39
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 1
FWCI
3.43
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
dehydration, skeletal muscle metabolism, cycling exercise, female athletes, substrate oxidation, carbohydrate oxidation, muscle glycogenolysis, lactate, core body temperature, plasma volume loss, sweat loss, fluid replacement, heat transfer
MeSH terms
Bicycling, Body Temperature, Dehydration, Epinephrine, Fatty Acids, Nonesterified, Female, Heart Rate, Humans, Oxygen Consumption, Sweat, Weight Loss, Muscle, Skeletal, Lactic Acid, Carbohydrate Metabolism, Glycogenolysis, Young Adult

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