The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Blood Flow Restriction Enhances Post–Resistance Exercise Angiogenic Gene Expression
Open accessAbstract
PURPOSE: The objective of this study is to evaluate the effects of blood flow restriction (BFR) on muscle oxygenation during low-intensity resistance exercise as well as postexercise expression of molecules related to physiological angiogenesis. METHODS: Using a randomized cross-over design, six apparently healthy young adults (22 ± 1 yr) performed 120 unilateral knee extensions at 40% of 1 repetition maximum with and without BFR (CNTRL). Near-infrared spectroscopy was used to measure oxygenation of the vastus lateralis during exercise. Serum and muscle expression of Post-Resistance vascular endothelial growth factor (VEGF) were determined preexercise, 4 h postexercise, and 24 h postexercise. Transcript (mRNA) expression of VEGF and other angiogenic genes was also determined. RESULTS: BFR increased muscle hemoglobin (Hb) concentrations during exercise (14.4 ± 1.6 vs. 0.9 ± 1.6, P = 0.002), driven largely by an increase in deoxygenated Hb (11.0 ± 2.5 vs. 0.5 ± 1.1, P = 0.030). BFR also increased (P < 0.05) transcript expression of VEGF, VEGF-R2, hypoxia-inducible factor 1 alpha, inducible nitric oxide synthase (NOS), and neuronal NOS. The most dramatic change in response to BFR was an increase in VEGF mRNA at 4 h postexercise (4.1 ± 0.6 vs. 0.6 ± 0.2-fold change, P = 0.028). Compared with control, transcript expression of endothelial NOS, serum VEGF, or muscle protein expression of VEGF was not altered in response to BFR (P > 0.05). CONCLUSION: Acute BFR increases postexercise expression of mRNA related to skeletal muscle angiogenesis, plausibly in response to changes in muscle Hb concentrations.
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Cites
Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332
Progression Models in Resistance Training for Healthy Adults
(2002) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200202000-00027 · Cited by 2,979
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
Pilegaard, H., Ordway, G. A., Saltin, B., & Neufer, P. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e806 · Cited by 563
Physiological activation of hypoxia inducible factor‐1 in human skeletal muscle
Ameln, H., Gustafsson, T., Sundberg, C. J., Okamoto, K., Jansson, E., Poellinger, L., & Makino, Y. (2005) · The FASEB Journal · doi:10.1096/fj.04-2304fje · Cited by 276
Hudlicka, O., & Brown, M. D. (2009) · Journal of Vascular Research · doi:10.1159/000226127 · Cited by 150
Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.008 · Cited by 113
Effects of Age and Sedentary Lifestyle on Skeletal Muscle NF- B Signaling in Men
Buford, T. W., Cooke, M. B., Manini, T. M., Leeuwenburgh, C., & Willoughby, D. S. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp196 · Cited by 78
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Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety
Patterson, S. D., Hughes, L., Warmington, S., Burr, J., Scott, B. R., Owens, J., Abe, T., Nielsen, J. L., Libardi, C. A., Laurentino, G., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00533 · Cited by 917
Jessee, M. B., Buckner, S. L., Mouser, J. G., Mattocks, K. T., Dankel, S. J., Abe, T., Bell, Z. W., Bentley, J. P., & Loenneke, J. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01448 · Cited by 164
Blood flow restriction does not augment low force contractions taken to or near task failure
Buckner, S. L., Jessee, M. B., Dankel, S. J., Mattocks, K. T., Mouser, J. G., Bell, Z. W., Abe, T., Bentley, J. P., & Loenneke, J. P. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2019.1664640 · Cited by 41
Popov, D. V., Lysenko, E. A., Bachinin, A. V., Miller, T. F., Kurochkina, N. S., Kravchenko, I. V., Furalyov, V. A., & Vinogradova, O. L. (2015) · Muscle & Nerve · doi:10.1002/mus.24314 · Cited by 32
Metadata
- Authors
- LARKIN, K. A., MACNEIL, R. G., DIRAIN, M., SANDESARA, B., MANINI, T. M., & BUFORD, T. W.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2012-11
- Volume
- 44
- Issue
- 11
- Pages
- 2077-2083
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2023261133
- Cited by
- 169
- References
- 7
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- green
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- LARKIN, K. A., MACNEIL, R. G., DIRAIN, M., SANDESARA, B., MANINI, T. M., & BUFORD, T. W. (2012). Blood Flow Restriction Enhances Post–Resistance Exercise Angiogenic Gene Expression. Medicine & Science in Sports & Exercise. https://doi.org/10.1249/mss.0b013e3182625928
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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