Cited by 260Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

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Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia: Primary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)

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Matsuzaki, Masunori, Kita, Toru, Mabuchi, Hiroshi, Matsuzawa, Yuji, Nakaya, Noriaki, Oikawa, Shinichi, Saito, Yasushi, Sasaki, Jun, Shimamoto, Kazuaki, Itakura, Hiroshige, the J-LIT Study Group·2002·Circulation Journal

DOI 10.1253/circj.66.1087

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Abstract

Hyperlipidemia is a well-established risk factor for primary coronary heart disease (CHD). Although simvastatin is known to lower serum lipid concentrations, the protective effect of such lipid-lowering therapy against primary CHD has not been established in Japanese patients with hypercholesterolemia. The Japan Lipid Intervention Trial was a 6-year, nationwide cohort study of 47,294 patients treated with open-labeled simvastatin (5-10 mg/day) and monitored by physicians under standard clinical conditions. The aim of the study was to determine the relationship between the occurrence of CHD and the serum lipid concentrations during low-dose simvastatin treatment. Simvastatin reduced serum concentrations of total cholesterol (TC), low-density lipoprotein- cholesterol (LDL-C) and triglyceride (TG), by 18.4%, 26.8% and 16.1% on average, respectively, during the treatment period. The risk of coronary events was higher when the average TC concentration was > or =240 mg/dl and the average LDL-C concentration was > or =160 mg/dl. The incidence of coronary events increased in the patients with TG concentration > or =300 mg/dl compared with patients with TG concentration <150 mg/dl. The high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of coronary events. The J-curve association was observed between average TC or LDL-C concentrations and total mortality. Malignancy was the most prevalent cause of death. The health of patients should be monitored closely when there is a remarkable decrease in TC and LDL-C concentrations with low-dose statin. A reasonable strategy to prevent coronary events in Japanese hypercholesterolemic patients without prior CHD under low-dose statin treatment might be regulating the serum lipid concentrations to at least <240 mg/dl for TC, <160 mg/dl for LDL-C, <300 mg/dl for TG, and >40 mg/dl for HDL-C.

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Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia and Coronary Heart Disease: Secondary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)
Mabuchi, H., Kita, T., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.1096 · Cited by 132
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Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51,321 Japanese hypercholesterolemic patients - Implication of the J-LIT study, a large scale nationwide cohort study
Matsuzawa, Y., Kita, T., Mabuchi, H., Matsuzaki, M., Nakaya, N., Oikawa, S., Saito, Y., SASAKI, J., Shimamoto, K., Itakura, H., et al. (2003) · Institutional Repositories DataBase (IRDB)
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Authors: Matsuzaki, M., Kita, T., Mabuchi, H., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., & the J-LIT Study Group
Affiliations: Yamaguchi University (JP)
Kyoto University (JP)
Kanazawa University (JP)
Osaka University Graduate School of Medicine
Fussa Hospital (JP)
Nippon Medical School (JP)
Chiba University Graduate School of Medicine
International University Graduate School of Health and Welfare
Sapporo Medical University (JP)
Ibaraki Christian University (JP)
ORCID: Oikawa, Shinichi
Venue: Circulation Journal
Publisher: Japanese Circulation Society
Published: 2002
Volume: 66
Issue: 12
Pages: 1087-1095
ISSN: 1346-9843 (ISSN-L)
1347-4820
DOI: 10.1253/circj.66.1087
OpenAlex: W2004878568
Cited by: 260
References: 52
Citations by year: 2025: 1 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 12 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 17 · 2013: 17 · 2012: 12
FWCI: 14.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Journal (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: simvastatin, hypercholesterolemia, coronary artery disease, serum cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, J-curve, lipid-lowering therapy, all-cause mortality, statin therapy, Japanese patients
MeSH terms: Adult, Aged, Anticholesteremic Agents, Cholesterol, Coronary Disease, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Lipids, Male, Middle Aged, Osmolar Concentration, Risk Factors, Safety, Cohort Studies, Incidence, Simvastatin

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Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia: Primary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)

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