Lower High-Density Lipoprotein Cholesterol is a Significant and Independent Risk for Coronary Artery Disease in Japanese Men
Open accessAbstract
AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.
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The risk for CAD increases when HDL-C levels are less than 40 mg/dL.
“It has been revealed in regional and occupational cohort studies that the risk for CAD increases when HDL-C levels are < 40 mg/dL46, 53, 78, 79).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [78]
Evidence on the association between gender discrepancy in HDL-C levels and CAD in each gender is insufficient.
“there is still insufficient evidence on the association between the discrepancy in HDL-C levels because of gender differences and CAD in each gender78).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [78]
Conditions such as metabolic syndrome that involve the clustering of multiple risk factors have been shown to increase the risk of cardiovascular diseases in epidemiological studies and meta-analyses, as well as in CIRCS study, Tanno and Sobetsu study, and Hisayama study.
“Conditions, such as metabolic syndrome, that involve the clustering of multiple risk factors have been shown to increase the risk of cardiovascular diseases in epidemiological studies323–326) and meta-analyses327), as well as in CIRCS study78), the Tanno and Sobetsu study328) and the Hisayama study317).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [78]
Epidemiological studies conducted in Japan have indicated that there is no significant relationship between the serum cholesterol levels (TC, LDL-C, and non-HDL-C) and the incidence rate of noncardiogenic cerebral infarction.
“However, the results of epidemiological studies conducted in Japan have indicated that there is no significant relationship between the serum cholesterol levels (TC, LDL-C, and non-HDL-C) and the incidence rate of noncardiogenic cerebral infarction36, 38, 40, 57, 64, 78, 337).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [78]
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- Authors
- Satoh, H., Tomita, K., Fujii, S., Kishi, R., & Tsutsui, H.
- Affiliations
- Hokkaido University (JP)
- NTT (Japan) (JP)
- Nagoya City University (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2009
- Volume
- 16
- Issue
- 6
- Pages
- 792-798
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2119240687
- Cited by
- 18
- References
- 30
- Citations by year
- 2024: 3 · 2023: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- low HDL cholesterol, coronary artery disease, cardiovascular risk factors, Japanese men, acute myocardial infarction, angina pectoris, independent risk factor
- MeSH terms
- Adult, Angina Pectoris, Coronary Artery Disease, Follow-Up Studies, Humans, Japan, Cholesterol, HDL, Male, Middle Aged, Myocardial Infarction, Risk Factors, Time Factors, Cohort Studies, Body Mass Index, Proportional Hazards Models
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