Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia and Coronary Heart Disease: Secondary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)
Open accessAbstract
Hyperlipidemia is primarily implicated in the progression of coronary heart disease (CHD) and its treatment is essential for patients with a history of CHD. Statins such as simvastatin, the lipid-lowering agents, are well-known for their ability to normalize patient's serum lipid levels. The Japan Lipid Intervention Trial study of simvastatin is the first nationwide investigation of the relationship between serum lipid levels and the development of CHD in Japanese patients with hypercholesterolemia. Of 5,127 patients, exclusively with a history of documented CHD at enrollment, 4,673 were treated with open-labeled simvastatin at an initial dose of 5-10 mg/day and were monitored for 6 years. The risk of coronary events tended to be higher in patients with a serum total cholesterol (TC) > or =240 mg/dl compared with total cholesterol <240 mg/dl. The concentration of low-density lipoprotein cholesterol (LDL-C) positively correlated and that of high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of CHD. Each 10 mg/dl decrease in LDL-C and each 10 mg/dl increase in HDL-C concentration reduced the risk of CHD by 8.0% (95% confidence interval 3.8-12.0) and 28.3% (95% CI 13.9-40.3), respectively. A reasonable therapeutic strategy to reduce CHD progression in patients with prior CHD under low-dose statin treatment might be regulating the serum LDL-C concentration to at least <120 mg/dl and HDL-C >40 mg/dl, respectively.
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In J-LIT primary prevention, the relative risk was 1.3 times higher in the HDL-C less than 40 mg/dL group than in the 40-49 mg/dL group.
“in the J-LIT study that involved a cohort of simvastatin users, the relative risk was 1.3 times higher in the < 40 mg/dL group than in the 40–49 mg/dL group in primary prevention81).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [81]
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- Authors
- Mabuchi, H., Kita, T., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., & the J-LIT Study Group
- Affiliations
- Kanazawa University (JP)
- Kyoto University (JP)
- Yamaguchi University (JP)
- Osaka University Graduate School of Medicine
- Fussa Hospital (JP)
- Nippon Medical School (JP)
- Chiba University Graduate School of Medicine
- International University Graduate School of Health and Welfare
- Sapporo Medical University (JP)
- Ibaraki Christian University (JP)
- ORCID
- Oikawa, Shinichi
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2002
- Volume
- 66
- Issue
- 12
- Pages
- 1096-1100
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2144437066
- Cited by
- 132
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 10 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 12 · 2012: 7
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- simvastatin, hypercholesterolemia, coronary artery disease, LDL cholesterol, HDL cholesterol, total cholesterol, statin therapy, coronary events, lipid-lowering therapy, cardiovascular risk
- MeSH terms
- Adult, Aged, Anticholesteremic Agents, Cholesterol, Coronary Disease, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Lipids, Male, Middle Aged, Osmolar Concentration, Risk Factors, Cohort Studies, Simvastatin
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