Fasting Triglyceride is a Significant Risk Factor for Coronary Artery Disease in Middle-Aged Japanese Men Results From a 10-Year Cohort Study
Open accessAbstract
BACKGROUND: It has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and the occurrence of CAD is controversial. The objective of this study was to elucidate the relationship between fasting TG and CAD in middle-aged Japanese men. METHODS AND RESULTS: A cohort study of 6,966 middle-aged Japanese men (mean +/- SD: 46.6+/-5.2 years) with a 10-year follow-up period was conducted to identify risk factors for the occurrence of CAD. One hundred and eleven cases of CAD were identified during the follow up. The Cox proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, alcohol intake, duration of sleeping, systolic blood pressure, uric acid, total cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, and TG. Fasting TG was identified as an independent risk factor for CAD. The adjusted hazard ratio of TG for CAD was 3.07 (95% confidence interval: 1.01-9.35, p<0.05). Additionally, a serum TG concentration level greater than 78 mg/dl was a significant risk for CAD. CONCLUSIONS: By using the long term follow-up data of the study of middle-aged Japanese men, fasting TG was identified to be a significant risk factor for CAD.
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The association between TG and CAD was observed even with normal HDL-C.
“Despite a normal range of HDL-C, the association between TG and CAD was still observed in several of these studies86–89).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [88]
A nonfasting TG level of 165 mg/dL or higher adds to the risk for MI, exercise-induced angina, sudden death, or ischemic CVD.
“These surveys have also shown that a nonfasting TG level of ≥ 165 mg/dL adds to the risk for MI, exercise-induced angina, sudden death88) or ischemic CVD91).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [88]
Postprandial hyperlipidemia is a risk factor for CAD.
“Postprandial hyperlipidemia is a risk factor for CAD. (Evidence level: E-1b)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [88]
Every 1 mmol/L increase in TG levels increases the relative risk of CAD by 1.34 times (men, 1.29 times; women, 1.42 times).
“Overall, every 1 mmol/L increase in TG levels increases the relative risk of CAD by 1.34 times (men, 1.29 times; women, 1.42 times)88).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [88]
A high nonfasting TG level adds to the risk of CAD.
“Epidemiological studies in Japan have also demonstrated that a high nonfasting TG level adds to the risk of CAD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [88]
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Self-citation
- Authors
- Satoh, H., Nishino, T., Tomita, K., & Tsutsui, H.
- Affiliations
- Hokkaido University (JP)
- NTT (Japan) (JP)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2006
- Volume
- 70
- Issue
- 3
- Pages
- 227-231
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2065848711
- Cited by
- 60
- References
- 31
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 1 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- fasting triglycerides, coronary artery disease, dyslipidemia, cardiovascular risk factors, middle-aged men, Japanese men, hypertriglyceridemia
- MeSH terms
- Adult, Age Factors, Cholesterol, Coronary Artery Disease, Fasting, Humans, Japan, Cholesterol, HDL, Longitudinal Studies, Male, Middle Aged, Risk Factors, Triglycerides, Cohort Studies, Proportional Hazards Models, Dyslipidemias
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