Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)
Abstract
Background Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited.Methods We used 1975-1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40-69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (<8 h after meal) participants.Results During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14-2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25-2.05), P for trend <0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant.Conclusion Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.
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In Japanese epidemiological surveys, the occurrence of CAD increases when fasting TG levels are 150 mg/dL or higher.
“It has been shown in epidemiological surveys in Japan that the occurrence of CAD increases when fasting TG levels of are ≥ 150 mg/dL46, 90).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [90]
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- Authors
- Iso, H., Imano, H., Yamagishi, K., Ohira, T., Cui, R., Noda, H., Sato, S., Kiyama, M., Okada, T., Hitsumoto, S., Tanigawa, T., & Kitamura, A.
- Affiliations
- The University of Osaka (JP)
- Osaka Center for Cancer and Cardiovascular Disease Prevention (JP)
- University of Tsukuba (JP)
- Chiba Prefectural Institute of Public Health (JP)
- Ehime University Hospital (JP)
- Ehime University (JP)
- ORCID
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 237
- Issue
- 1
- Pages
- 361-368
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1977704640
- Cited by
- 104
- References
- 39
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (04304036, 02454209, 50223053, 06454234, 08457125, 10470103, 12470092, 19590629, 19590663, 15659146)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- fasting triglycerides, ischemic cardiovascular disease, ischemic heart disease, ischemic stroke, dyslipidemia, sex differences, HDL cholesterol, Japanese adults, Circulatory Risk in Communities Study
- MeSH terms
- Adult, Aged, Fasting, Female, Follow-Up Studies, Humans, Japan, Cholesterol, HDL, Male, Middle Aged, Risk Factors, Triglycerides, Multivariate Analysis, Proportional Hazards Models, Treatment Outcome, Myocardial Ischemia, Stroke
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