Combined Cardiovascular Risk Factors and Outcome: NIPPON DATA80, 1980-1994
Open accessAbstract
BACKGROUND: To examine the prognostic significance of the high-risk group with combined cardiovascular risk factors in the Japanese, we analyzed the relationship between the high-risk group with combined risks and coronary heart disease (CHD) and stroke mortality using the NIPPON DATA80 database. METHODS AND RESULTS: At baseline in 1980, those of age>or=30 years were randomly selected and 4,144 men and 5,318 women without CHD and/or stroke at baseline were followed for 14 years. The cutoff values for risk components obtained heuristically by Cox analysis were hypertension (systolic>or=130, or diastolic>or=85 mmHg, or on antihypertensive drugs), hypercholesterolemia (total cholesterol>or=200 mg/dl), hyperglycemia (>or=130 mg/dl, or self-reported diabetes) and obesity (body mass index>or=27 kg/m2). Subjects were divided into 3 groups (0, 1-2 and 3-4 risks). Compared with those men in the risk 0 group, the hazard ratios in men in the risk 3-4 for CHD mortality was 8.04 (95% confidence interval: 1.03-62.6), and the stroke mortality was 5.06 (1.53-16.7). In women, no statistically significant difference was found due to a lesser number of events. CONCLUSION: The high-risk group with combined risk factors is important risk for Japanese men.
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The relative risk of death due to CAD and stroke increased with the number of combined risk factors.
“The NIPPON DATA80 epidemiological study also showed that the relative risk of death due to CAD and stroke increased with the number of combined risk factors314–317)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [315]
BMI, BP, fasting blood glucose, and serum lipids levels were significantly higher in cases compared with controls for the evaluated 10-year period, even though these abnormalities were mild or moderate.
“The surveys revealed that BMI, BP, fasting blood glucose, and serum lipids levels were significantly higher in cases compared with those in controls for the evaluated 10-year period, even though these abnormalities were mild or moderate.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [315]
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- Authors
- Nakamura, Y., Yamamoto, T., Okamura, T., Kadowaki, T., Hayakawa, T., Kita, Y., Saitoh, S., Okayama, A., Ueshima, H., & The NIPPON DATA 80 Research Group
- Affiliations
- Kyoto Women's University (JP)
- Shiga University of Medical Science (JP)
- Shimane University (JP)
- Sapporo Medical University (JP)
- Department of Preventive Cardiology, National Cardiovascular Center
- ORCID
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2006
- Volume
- 70
- Issue
- 8
- Pages
- 960-964
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W1975343824
- Cited by
- 81
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 7
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- coronary heart disease mortality, stroke mortality, hypertension, hypercholesterolemia, hyperglycemia, obesity, Japanese men, NIPPON DATA80, prognostic value
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Female, Humans, Hypercholesterolemia, Hyperglycemia, Hypertension, Japan, Male, Middle Aged, Obesity, Prognosis, Reference Values, Risk Factors, Cohort Studies, Proportional Hazards Models, Stroke
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