Trend of Increase in the Incidence of Acute Myocardial Infarction in a Japanese Population: Takashima AMI Registry, 1990-2001
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The incidence and mortality of acute myocardial infarction (AMI) remain low in Japan despite major dietary changes and worsening cardiovascular risk factors, a situation that should have resulted in a substantial increase in AMI rates (Japanese paradox). The current trend in the incidence of AMI was examined for the period 1990-2001 by use of data from the Takashima AMI Registry covering a stable population of approximately 55,000 in central Japan. AMI incidence rates (per 100,000 person-years) and 95% confidence intervals were calculated for 1990-1992, 1993-1995, 1996-1998, and 1999-2001. The incidence trend was determined by calculating the average annual change in percentage across the years. There were 352 (men: n = 224; women: n = 128) registered first-ever AMI cases during 1990-2001. The age-adjusted incidence rate of all AMI showed a gradual increase from 39.9 (95% confidence interval (CI): 29.8, 50.0) in 1990-1992 to 62.6 (95% CI: 51.5, 73.7) in 1999-2001. In men, the age-adjusted incidence rate increased from 66.5 (95% CI: 46.4, 86.6) in 1990-1992 to 100.7 (95% CI: 78.6, 122.7) in 1999-2001. In women, fluctuation was observed after an initial steep increase. The average annual incidence increased by 7.6% (95% CI: 3.5, 11.7) among men and by 8.3% (95% CI: 1.02, 15.6) among women. To the best of the authors' knowledge, this is the first study to report an increasing trend of AMI in a Japanese population.
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In terms of absolute risk, aging enhances the risk for ASCVD and death from it much more than any other risk factors.
“In terms of absolute risk, aging enhances the risk for ASCVD and death from it much more than any other risk factors160–162).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [162]
There are several assessment tools that predict the absolute risk of ASCVD in the Japanese population.
“There are several assessment tool that predict the absolute risk of ASCVD in the Japanese population.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [162]
Hisayama score and Suita score include the most suitable criteria for assessment of absolute risk relevant to primary prevention of ASCVD in Japanese adults by managing dyslipidemia.
“we concluded that the Hisayama score334) and the Suita score162) include the most suitable criteria for assessment of absolute risk relevant to the primary prevention of ASCVD in Japanese adults by managing dyslipidemia.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [162]
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Self-citationDiabetes and lifetime risk of coronary heart disease
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Self-citationCoronary Artery Calcium Progression Among the US and Japanese Men
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Romosozumab and cardiovascular safety in Japan
Takeuchi, Y. (2021) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2021.09.002 · Cited by 15 · see citing works
Hisamatsu, T., & Kinuta, M. (2023) · Journal of atherosclerosis and thrombosis · doi:10.5551/jat.rv22009 · Cited by 17 · see citing works
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Al-Shoaibi, A. A. A., Li, Y., Song, Z., Chiang, C., Hirakawa, Y., Saif‐Ur‐Rahman, K., Shimoda, M., Nakano, Y., Matsunaga, M., Aoyama, A., et al. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63519 · Cited by 14 · see citing works
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Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men
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Impact of retinal vein occlusion on cardiovascular events in elderly Japanese patients
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Cardioprotection in the Clinical Setting-Lessons from J-WIND Studies
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Residual lifetime risk of cardiovascular diseases in Japan.
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Cardiovascular safety of osteoanabolic agents
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Current status and future perspective of cardiac rehabilitation in Japan
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Knowledge Translation for Cardiovascular Disease Research and Management in Japan
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Percutaneous Coronary Intervention
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Predictors of In-Hospital Death in Patients With Acute Myocardial Infarction
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- Authors
- Rumana, N., Kita, Y., Turin, T. C., Murakami, Y., Sugihara, H., Morita, Y., Tomioka, N., Okayama, A., Nakamura, Y., Abbott, R. D., & Ueshima, H.
- Affiliations
- Shiga University of Medical Science (JP)
- Otsu Red Cross Hospital (JP)
- Kyoto Women's University (JP)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-25
- Volume
- 167
- Issue
- 11
- Pages
- 1358-1364
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2101922914
- Cited by
- 121
- References
- 29
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- acute myocardial infarction, incidence trends, age-adjusted incidence, sex differences in incidence, cardiovascular risk factors, dietary change, Japan
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Japan, Male, Middle Aged, Myocardial Infarction, Registries, Incidence, Poisson Distribution, Linear Models
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