Coronary Risk Factor Profile and Prognostic Factors for Young Japanese Patients Undergoing Coronary Revascularization
Open accessAbstract
BACKGROUND: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. METHODS AND RESULTS: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (< or =55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25 kg/m(2), current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. CONCLUSIONS: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.
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The J-LIT study showed that a family history of CAD increases the relative risk of developing CAD by three times.
“The J-LIT study in Japan has shown that a family history of CAD increases the relative risk of developing CAD by three times173).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [173]
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- Authors
- Furukawa, Y., Ehara, N., Taniguchi, R., Haruna, Y., Ozasa, N., Saito, N., Doi, T., Hoshino, K., Tamura, T., Shizuta, S., Abe, M., Toma, M., Morimoto, T., Teramukai, S., Fukushima, M., Kita, T., Kimura, T., & CREDO-Kyoto Investigators
- Affiliations
- Kobe City Medical Center General Hospital (JP)
- Division of Cardiology, Hyogo Prefectural, Amagasaki Hospital
- Hirakata Kohsai Hospital (JP)
- Kyoto University Hospital (JP)
- Division of Cardiology, Nagai Hospital
- Division of Cardiology, National Cardiovascular Center
- Kyoto University (JP)
- Translational Research Informatics Center
- Investigators in the Coronary Revascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry are listed in Appendix A.
- ORCID
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2009
- Volume
- 73
- Issue
- 8
- Pages
- 1459-1465
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W2080044322
- Cited by
- 25
- References
- 45
- Citations by year
- 2023: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2013: 6 · 2012: 2
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- coronary artery disease, young adults, coronary revascularization, major adverse cardiovascular events, chronic kidney disease, cardiovascular risk factors, metabolic syndrome, dyslipidemia, smoking, obesity, family history of CAD, Japanese patients, prognostic factors
- MeSH terms
- Age Factors, Chronic Disease, Coronary Artery Disease, Female, Humans, Japan, Kidney Diseases, Male, Middle Aged, Myocardial Revascularization, Prognosis, Risk Factors, Multivariate Analysis, Age Distribution, Asian People
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