Homocysteine and Arginine-to-Asymmetric Dimethylarginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease
Open accessAbstract
BACKGROUND: Less attention has been paid to evaluating subclinical cardiovascular disease (CVD) in the early stage of pediatric chronic kidney disease (CKD). Ambulatory blood pressure monitoring (ABPM) and arterial stiffness are the earliest detectable assessments of subclinical CVD. Asymmetric dimethylarginine (ADMA) is an analog of L-arginine (ARG) that inhibits nitric oxide (NO) production; thus the ARG-to-ADMA ratio (AAR) is an index of NO. Homocysteine (HCY) is a risk factor for CVD and it can be metabolized to L-cysteine (CYS). Given that HCY and ADMA/NO are closely linked and related to hypertension, we therefore investigated whether ARG and HCY metabolites, arterial stiffness parameters, ABPM profile, and left ventricular hypertrophy (LVH) are interrelated in children and adolescents with early CKD. METHODS AND RESULTS: This cross-sectional study included 57 pediatric patients with CKD stages 1-3. Two-thirds of the children with CKD stages 1-3 exhibited BP abnormalities accessed by ABPM. Children with CKD stages 2-3 had higher HCY, but lower CYS levels. The plasma HCY level was increased in children with LVH and abnormal ABPM. Systolic BP positively correlated with biomarkers AAR, HCY, and CYS. LV mass positively correlated with AAR, HCY, and CYS. CONCLUSIONS: BP abnormalities were prevalent and associated with AAR, HCY, and CYS in children with early CKD. Our data highlighted the effect of NO and the HCY pathway on CKD-related hypertension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deteriorated renal function correlates with altered markers of oxidative stress including mitochondrial oxidized LDL, homocysteine, and deficiency of reduced glutathione (GSH) and superoxide dismutase (SOD).
“Deteriorated renal function correlates well with the altered markers of oxidative stress. These involve mitochondrial oxidized low-density lipoprotein (Garcia-Bello et al. 2014), homocysteine (Chien et al. 2015), and deficiency of reduced glutathione (GSH) and superoxide dismutase (SOD) (Garcia-Bello et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Chien et al. 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Establishing a standard definition for child overweight and obesity worldwide: international survey
Cole, T. J. (2000) · BMJ · doi:10.1136/bmj.320.7244.1240 · Cited by 16,500 · see citing works
Levey, A. S., Coresh, J., Bolton, K., Culleton, B. F., Harvey, K. S., Ikizler, T. A., Johnson, C. A., Kausz, A., Kimmel, P. L., Kusek, J. W., et al. (2002) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 11,633 · see citing works
New Equations to Estimate GFR in Children with CKD
Schwartz, G. J., Tilde]oz, A. M., Schneider, M. F., MAK, R. H. K., Kaskel, F. J., Warady, B. A., & Furth, S. L. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030287 · Cited by 3,782 · see citing works
Strict Blood-Pressure Control and Progression of Renal Failure in Children
The ESCAPE Trial Group (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902066 · Cited by 951 · see citing works
Wühl, E., Witte, K. K., Soergel, M., Mehls, O., & Schaefer, F. S. (2002) · Journal of Hypertension · doi:10.1097/00004872-200210000-00019 · Cited by 816 · see citing works
Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707 · see citing works
Hogg, R. J., Furth, S. L., Lemley, K. V., Portman, R. J., Schwartz, G. J., Coresh, J., Balk, E. M., Lau, J., Levin, A., Kausz, A. T., et al. (2003) · PEDIATRICS · doi:10.1542/peds.111.6.1416 · Cited by 698 · see citing works
Homocysteine Impairs the Nitric Oxide Synthase Pathway
Stuehlinger, M., Tsao, P. S., Her, J. H., Kimoto, M., Balint, R. F., & Cooke, J. P. (2001) · Circulation · doi:10.1161/hc4601.098514 · Cited by 662 · see citing works
Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents
Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L. L., Jacobson, M., Mahoney, L. T., Mietus‐Snyder, M., Rocchini, A. P., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 642 · see citing works
Age-Specific Reference Intervals for Indexed Left Ventricular Mass in Children
Khoury, P. R., Mitsnefes, M. M., Daniels, S. R., & Kimball, T. R. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.03.003 · Cited by 570 · see citing works
Arterial stiffness and pulse pressure in CKD and ESRD
Briet, M. B., Boutouyrie, P., Laurent, S., & London, G. M. (2012) · Kidney International · doi:10.1038/ki.2012.131 · Cited by 390 · see citing works
The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio
BODEBOGER, S., SCALERA, F., & IGNARRO, L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.002 · Cited by 347 · see citing works
Masked Hypertension Associates with Left Ventricular Hypertrophy in Children with CKD
Mitsnefes, M. M., Flynn, J. T., Cohn, S. E., Samuels, J., Blydt‐Hansen, T. D., Saland, J. M., Kimball, T. R., Furth, S. L., & Warady, B. A. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009060609 · Cited by 326 · see citing works
Asymmetric Dimethylarginine and Progression of Chronic Kidney Disease
Fliser, D., Kronenberg, F., Kielstein, J. T., Morath, C. P., Bode‐Böger, S. M., Haller, H. G., & Ritz, E. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005020179 · Cited by 310 · see citing works
Böger, R. H., Maas, R., Schulze, F., & Schwedhelm, E. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.001 · Cited by 205 · see citing works
Carotid Intima-Media Thickness in Children with CKD
Brady, T. M., Schneider, M. F., Flynn, J. T., Cox, C., Samuels, J., Saland, J. M., White, C. T., Furth, S. L., Warady, B. A., & Mitsnefes, M. M. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03130312 · Cited by 122 · see citing works
Feig, D. I., Kang, D., Nakagawa, T., et al. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0005-z · Cited by 115 · see citing works
Boutouyrie, P., Fliser, D., Goldsmith, D. J. A., Covic, A. C., Więcek, A., Ortíz, A., Martinez-Castelao, A., Lindholm, B., Massy, Z. A., Süleymanlar, G., et al. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft309 · Cited by 105 · see citing works
Ambulatory arterial stiffness index: A systematic review and meta-analysis
Κόλλιας, Α., Stergiou, G. S., Dolan, E., & O'Brien, E. T. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.03.039 · Cited by 100 · see citing works
Tain, Y., Huang, L., Lin, I.-C. F., Lau, Y., & Lin, C. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00806.x · Cited by 90 · see citing works
Self-citationHydrogen sulfide in renal physiology, disease and transplantation – The smell of renal protection
Koning, A. M., Frenay, A.-R. S., Leuvenink, H. G. D., & van Goor, H. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.01.005 · Cited by 81 · see citing works
Blood Pressure Control and Left Ventricular Mass in Children with Chronic Kidney Disease
Sinha, M. D., Tibby, S. M., Rasmussen, P., Rawlins, D., Turner, C., Dalton, R. N., Reid, C. J. D., Rigden, S. P. A., Booth, C. J., & Simpson, J. M. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04690510 · Cited by 70 · see citing works
Arterial Stiffness: A Nexus between Cardiac and Renal Disease
Jia, G., Aroor, A. R., & Sowers, J. R. (2014) · Cardiorenal Medicine · doi:10.1159/000360867 · Cited by 62 · see citing works
Hyperuricemia in Obese Children and Adolescents: The Relationship with Metabolic Syndrome
Tang, L., Kubota, M., Nagai, A., et al. (2010) · Pediatric Reports · doi:10.4081/pr.2010.e12 · Cited by 59 · see citing works
Improved HPLC method for total plasma homocysteine detection and quantification.
Sawuła, W., Banecka-Majkutewicz, Z., Kadziński, L., Jakóbkiewicz‐Banecka, J., Węgrzyn, G., Nyka, W. M., & Banecki, B. (2008) · Acta Biochimica Polonica · doi:10.18388/abp.2008_3161 · Cited by 45 · see citing works
Zhang, D., Wen, X., Zhang, L., & Cui, W. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0233 · Cited by 44 · see citing works
Hongo, M., Hidaka, H., Sakaguchi, S., et al. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0837 · Cited by 41 · see citing works
Ambulatory Blood Pressure and Cardiovascular Events in Chronic Kidney Disease
Agarwal, R. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2007.07.001 · Cited by 33 · see citing works
Arterial stiffness in chronic kidney disease
Taal, M. W. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000441153.40072.e0 · Cited by 33 · see citing works
van Guldener, C., Nanayakkara, P. W. B., & Stehouwer, C. D. A. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.340 · Cited by 31 · see citing works
Kuo, H.-C., Hsu, C., Huang, C.-F., Lo, M., Chien, S., & Tain, Y. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.09.003 · Cited by 26 · see citing works
Self-citationWu, T.-H., Kuo, H.-C., Tain, Y., et al. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-98 · Cited by 24 · see citing works
Self-citationLin, Y.-J., Hsu, C., Lo, M., Huang, C.-F., Chien, S., & Tain, Y. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0602 · Cited by 23 · see citing works
Self-citationOscillometric ambulatory blood pressure values in healthy children.
Weng, K.-P., Hsieh, K., Huang, S., et al. (2002) · PubMed · Cited by 11 · see citing works
Kai, H., Kaneyuki, M., Shihara, M., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1102 · Cited by 9 · see citing works
Tain, Y. (2007) · PubMed · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Chien, S.-J., Lin, I.-C., Hsu, C.-N., Lo, M.-H., & Tain, Y.-L.
- Affiliations
- Chang Gung University (TW)
- Kaohsiung Medical University (TW)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2015
- Volume
- 79
- Issue
- 9
- Pages
- 2031-2037
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W1886365915
- Cited by
- 39
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 1
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chang Gung Medical Foundation
- Kaohsiung Chang Gung Memorial Hospital (CMRPG8C0631)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- homocysteine, asymmetric dimethylarginine, nitric oxide, cysteine, pediatric chronic kidney disease, blood pressure abnormalities, hypertension, arterial stiffness, ambulatory blood pressure monitoring, left ventricular hypertrophy, subclinical cardiovascular disease, children and adolescents
- MeSH terms
- Adolescent, Arginine, Blood Pressure, Child, Cross-Sectional Studies, Female, Homocysteine, Humans, Hypertension, Male, Renal Insufficiency, Chronic, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
