CoChat
Sign Up
Cited by 17Blood Pressure and Hypertension StudiesSodium Intake and HealthRenin-Angiotensin System Studies

The effect of sodium depletion on plasma norepinephrine kinetics in patients with essential hypertension.

Open access
KIMURA, SHINOBU, MIURA, YUKIO, ADACHI, MAKI, ADACHA, MICHIKO, NEZU, MITSUHIRO, TORIYABE, SHUNICHI, SUGAWARA, TAKASHI, ISHIZUKA, YUKI +4 more·1983·Japanese Circulation Journal
DOI 10.1253/jcj.47.1232
Open this paper in CoChat — free accountOpen PDF

Abstract

The effects of sodium depletion on plasma norepinephrine (NE) kinetics were studied in 14 patients with essential hypertension using the steady state NE infusion technique on the theoretical basis of a two-compartmental open model. The calculated half time of rapid removal phase (t 1/2 alpha) of plasma NE was significantly delayed in the hypertensives (1.20 +/- 0.22 min, mean +/- SD) than in normal subjects (0.89 +/- 0.14) (p less than 0.01). The total clearance rates were comparable between the 2 groups (47 +/- 7 vs 48 +/- 11 ml/kg/min). The rates of the endogenous NE outflow into the circulation (RE-NE) were not significantly different between normal (5.29 +/- 1.68 ng/kg/min) and hypertensives (7.69 +/- 5.42), although 5 hypertensive patients (36%) showed an increased RE-NE above the normal range. The prolonged half time (t 1/2 alpha) in the hypertensives tended to be shortened after sodium depletion induced by either low sodium diet or diuretics (1.04 +/- 0.22, p less than 0.001). Both plasma NE and RE-NE were significantly increased after sodium depletion. A close correlation was observed between plasma NE and RE-NE (r = 0.907, p less than 0.001) in these subjects. These results suggest the slowed neuronal uptake of NE at the sympathetic nerve terminals in some patients with essential hypertension, occurring in part as a sodium-mediated consequence.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1253/jcj.47.1232

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In earlier studies, the half-time of the rapid disappearance phase of tritiated NE removal from plasma after infusion was prolonged in some patients with essential hypertension.

    “In these earlier studies, the half-time of the rapid disappearance phase of tritiated NE removal from plasma on termination of an intravenous infusion of the tracer, which is primarily, but not exclusively, dependent on neuronal NE uptake was found to be prolonged in some patients with essential hypertension.[5][6][7]”

    From Phenotypic Evidence of Faulty Neuronal Norepinephrine Reuptake in Essential Hypertension (2000) · cites this paper as [6]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
KIMURA, S., MIURA, Y., ADACHI, M., ADACHA, M., NEZU, M., TORIYABE, S., SUGAWARA, T., ISHIZUKA, Y., NOSHIRO, T., TAKAHASHI, M., OHASHI, H., & YOSHINAGA, K.
ORCID
Venue
Japanese Circulation Journal
Publisher
Japanese Circulation Society
Published
1983
Volume
47
Issue
10
Pages
1232-1241
ISSN
  • 0047-1828 (ISSN-L)
  • 1347-4839
DOI
10.1253/jcj.47.1232
OpenAlex
W2013524904
Cited by
17
References
42
Citations by year
2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 1
FWCI
0.73
Type
journal article
Language
en
Open access
Locations
  • Japanese Circulation Journal-english Edition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
sodium depletion, plasma norepinephrine, norepinephrine kinetics, essential hypertension, norepinephrine clearance, sodium restriction, diuretics, sympathetic nerve terminals
MeSH terms
Adolescent, Adult, Blood Pressure, Female, Heart Rate, Humans, Hypertension, Kinetics, Male, Middle Aged, Norepinephrine, Sodium, Vascular Resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review