Apoptotic cell death in neurons and glial cells: implications for Alzheimer's disease
Open accessAbstract
It is now generally accepted that massive neuronal death due to oxidative stress is a common characteristic of brains in neurodegenerative diseases. Recently, numerous apoptosis-regulating factors and multiple pathways have been identified, and apoptotic cell death has been implicated in neuronal loss in Alzheimer's disease. Although glial cells are more resistant to oxidative stress than neurons, extensive oxidative stress seems to cause apoptotic cell death in glial cells. In fact, signs of apoptosis are observed in both neurons and glial cells in the brains of patients with Alzheimer's disease. This review summarizes current findings regarding apoptotic processes and discusses the possible involvement of apoptosis-regulating factors in the pathology of Alzheimer's disease.
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NPD1 inhibited Aβ42-induced apoptosis in both glial and neuronal cell populations in a stressed HN cell model.
“In turn, NPD1 inhibited Aβ42-induced apoptosis in both glial and neuronal cell populations in a stressed HN cell model are in concordance with the findings of others on apoptosis in glial and neuronal cells in AD brain (Kitamura et al., 1999; Kobayashi et al., 2004; Paradisi et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Kitamura et al., 1999
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Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works
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- Authors
- Yoshihisa, K., Takashi, T., & Shun, S.
- Affiliations
- Kyoto Pharmaceutical University (JP)
- Kyoto University (JP)
- Venue
- Japanese Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1999
- Volume
- 79
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0021-5198 (ISSN-L)
- OpenAlex
- W2059304461
- Cited by
- 47
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The Japanese Journal of Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apoptosis, Alzheimer's disease, neuronal cell death, glial cells, oxidative stress, neurodegeneration, neuronal loss
- MeSH terms
- Alzheimer Disease, Animals, Humans, Neuroglia, Neurons, Oncogene Proteins, Apoptosis, Oxidative Stress
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