The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence
Abstract
Inflammatory bowel disease (IBD) comprises primarily the chronic relapsing inflammatory disorders, Crohn's disease and ulcerative colitis, with the former affecting any part of the gastrointestinal tract and the latter mainly afflicting the colon. The precise etiology of IBD remains unclear, and it is thought that interactions among various factors, including genetic factors, the host immune system and environmental factors, cause disruption of intestinal homeostasis, leading to dysregulated inflammatory responses of the gut. As inflammation is intimately related to formation of reactive intermediates, including reactive oxygen and nitrogen species (ROS/RNS), oxidative stress has been proposed as a mechanism underlying the pathophysiology of IBD. This review is intended to summarize succinctly recent new experimental and clinical evidence supporting oxidative stress as a pathophysiological component of IBD and point to the potential of using antioxidant compounds as promising therapeutic modalities of human IBD. The sources of ROS/RNS and the redox signaling mechanism underlying oxidative stress and inflammation in IBD are discussed to provide insight into the molecular basis of oxidative stress as a pathophysiological factor in IBD.
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Cites
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Cited by
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
Cao, S. S., & Kaufman, R. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.5851 · Cited by 1,363
Role of ROS and Nutritional Antioxidants in Human Diseases
Liu, Z., Ren, Z., Zhang, J., Chuang, C.-C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00477 · Cited by 860
Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues
Lee, M., & Chang, E. B. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.056 · Cited by 645
Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?
Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., Araújo, O. R. P., & Goulart, M. O. F. (2015) · Redox Biology · doi:10.1016/j.redox.2015.10.006 · Cited by 381
When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence
Lu, Z., & Imlay, J. A. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00583-y · Cited by 318
Metadata
- Authors
- Zhu, H., & Li, Y. R.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2012-05
- Volume
- 237
- Issue
- 5
- Pages
- 474-480
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2312701756
- Cited by
- 431
- References
- 52
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, H., & Li, Y. R. (2012). Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence. Experimental Biology and Medicine. https://doi.org/10.1258/ebm.2011.011358
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
