Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

Molecular mechanisms and clinical applications of angiogenesis

Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467

Hypoxia — a key regulatory factor in tumour growth

Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177

Radiobiology for the Radiologist.

(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

Pàez‐Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Viñals, F., Inoue, M., Bergers, G., Hanahan, D., & Casanovas, O. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.027 · Cited by 2,373

BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression

NandyMazumdar, M., Paranjapye, A., Browne, J. A., Yin, S., Leir, S., & Harris, A. (2021) · Biochemical Journal · doi:10.1042/bcj20210252 · Cited by 28

The Evolution and Future of Targeted Cancer Therapy: From Nanoparticles, Oncolytic Viruses, and Oncolytic Bacteria to the Treatment of Solid Tumors

Pierce, K. M., Miklavcic, W. R., Cook, K. P., Hennen, M. S., Bayles, K. W., Hollingsworth, M. A., Brooks, A. E., Pullan, J. E., & Dailey, K. M. (2021) · Nanomaterials · doi:10.3390/nano11113018 · Cited by 30

A General Approach to Design Dual Ratiometric Fluorescent and Photoacoustic Probes for Quantitatively Visualizing Tumor Hypoxia Levels In Vivo

Zhang, S., Chen, H., Wang, L., Qin, X., Jiang, B., Ji, S., Shen, X., & Liang, H. (2021) · Angewandte Chemie · doi:10.1002/ange.202107076 · Cited by 28

Hepatic Stellate Cells in Liver Tumor

Shiraha, H., Iwamuro, M., & Okada, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_4 · Cited by 27

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression

Nesbitt, H., Byrne, N. M., Williams, S. N., Ming, L., Worthington, J., Errington, R. J., Patterson, L. H., Smith, P. J., McKEOWN, S. R., & McKenna, D. J. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1361 · Cited by 26

Photophysical properties and photocytotoxicity of free and liposome-entrapped diazepinoporphyrazines on LNCaP cells under normoxic and hypoxic conditions

Wieczorek-Szweda, E., Młynarczyk, D. T., Kucińska, M., Długaszewska, J., Piskorz, J., Popenda, Ł., Szczołko, W., Jurga, S., Murias, M., Mielcarek, J., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.02.064 · Cited by 27

Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer

Taneja, S., Vetter, S. W., & Leclerc, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158153 · Cited by 28

Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment

Celora, G. L., Byrne, H. M., & Kevrekidis, P. G. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111248 · Cited by 27

Mg-based materials diminish tumor spreading and cancer metastases

Globig, P., Madurawala, R., Willumeit‐Römer, R., Martini, F., Mazzoni, E., & Luthringer-Feyerabend, B. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.002 · Cited by 27

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Cariello, M., Squilla, A., Piacente, M., Venutolo, G., & Fasano, A. (2022) · Molecules · doi:10.3390/molecules28010116 · Cited by 28

Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs

Shen, X., & Gates, K. S. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00036 · Cited by 28

Hypoxia differentially regulates estrogen receptor alpha in 2D and 3D culture formats

Whitman, N. A., Lin, Z.-W., Kenney, R. M., Sanchez, L. A., & Lockett, M. R. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.05.025 · Cited by 28

Regulation of the HIF switch in human endothelial and cancer cells

Slawski, J., Jaśkiewicz, M., Barton, A., Kozioł, S., Collawn, J. F., & Bartoszewski, R. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151386 · Cited by 26

Mitochondria as disease-relevant organelles in rheumatoid arthritis

Weyand, C. M., Wu, B., Huang, T., Hu, Z., & Goronzy, J. J. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac107 · Cited by 29

[Ru(dpp) 3 ]Cl 2 ‐Embedded Oxygen Nano Polymeric Sensors: A Promising Tool for Monitoring Intracellular and Intratumoral Oxygen Gradients with High Quantum Yield and Long Lifetime

Kumar, A., Goudar, V. S., Nahak, B. K., Tsai, P., Lin, H., & Tseng, F. (2023) · Small · doi:10.1002/smll.202307955 · Cited by 27

(Single-stranded DNA) gaps in understanding BRCAness

Schreuder, A., Wendel, T. J., Dorresteijn, C. G. V., & Noordermeer, S. M. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.04.013 · Cited by 25

Physicochemical Modulation Strategies for Mass Production of Extracellular Vesicle

Park, H., Seo, Y., Arai, Y., & Lee, S. (2025) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00726-9 · Cited by 28

The Production of Pro-angiogenic VEGF-A Isoforms by Hypoxic Human NK Cells Is Independent of Their TGF-β-Mediated Conversion to an ILC1-Like Phenotype

Hawke, L. G., Whitford, M. K., & Ormiston, M. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01903 · Cited by 30

Catalase-Loaded Silica Nanoparticles Formulated via Direct Surface Modification as Potential Oxygen Generators for Hypoxia Relief

Heble, A. Y., Santelli, J., Armstrong, A. M., Mattrey, R. F., & Lux, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c19633 · Cited by 26

Hypoxia and Its Influence on Radiotherapy Response of HPV-Positive and HPV-Negative Head and Neck Cancer

Wegge, M., Dok, R., & Nuyts, S. (2021) · Cancers · doi:10.3390/cancers13235959 · Cited by 27

Hypoxia‐induced miR‐210‐3p expression in lung adenocarcinoma potentiates tumor development by regulating CCL2 mediated monocyte infiltration

Arora, L., Patra, D., Roy, S., Nanda, S., Singh, N., Verma, A. K., Chakraborti, A., Dasgupta, S., & Pal, D. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13260 · Cited by 26

New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins

Papakonstantinou, A., Koumarianou, P., Rigakou, A., Diamantakos, P., Frakolaki, E., Vassilaki, N., Chavdoula, E., Melliou, E., Magiatis, P., & Boleti, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010003 · Cited by 26

Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance

Zaarour, R. F., Ribeiro, M., Azzarone, B. G., Kapoor, S., & Chouaı̈b, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1222575 · Cited by 25

Physiological Hypoxia (Physioxia) Impairs the Early Adhesion of Single Lymphoma Cell to Marrow Stromal Cell and Extracellular Matrix. Optical Tweezers Study

Duś‐Szachniewicz, K., Drobczyński, S., Ziolkowski, P. P., Kołodziej, P., Walaszek, K., Korzeniewska, A. K., Agrawal, A. K., Kupczyk, P., & Woźniak, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071880 · Cited by 25

The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway

Seok, J., Yoon, S., Lee, S., Jung, J. H., & Lee, Y. M. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4649 · Cited by 24

Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

Osrodek, M., Hartman, M. L., & Czyż, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174203 · Cited by 27

The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?

Mojsilović, S. S., Mojsilović, S. B., Villar, V. H., & Santibanez, J. F. (2021) · Analytical Cellular Pathology · doi:10.1155/2021/5523055 · Cited by 26

Doxorubicin-sensitive and -resistant colorectal cancer spheroid models: assessing tumor microenvironment features for therapeutic modulation

Valente, R., Cordeiro, S. Z., Luz, A., Melo, M. C., Roma‐Rodrigues, C., Baptista, P. V., & Fernandes, A. R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1310397 · Cited by 25

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Yang, Q., Dang, H., Liu, J., Wang, X., Wang, J., Lan, X., Ji, M., Xing, M., & Hou, P. (2023) · Oncogene · doi:10.1038/s41388-023-02659-w · Cited by 24

Mitochondrial metabolism regulation and epigenetics in hypoxia

Laird, M., Ku, J. C., Raiten, J., Sriram, S., Moore, M., & Li, Y. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1393232 · Cited by 26

Unravelling the role of tumor microenvironment responsive nanobiomaterials in spatiotemporal controlled drug delivery for lung cancer therapy

Srinivasarao, D. A., Shah, S., Famta, P., Vambhurkar, G. B., Jain, N., Pindiprolu, S. K. S. S., Sharma, A., Kumar, R., Padhy, H. P., Kumari, M., et al. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01673-z · Cited by 25

Harnessing hypoxia as an evolutionary driver of complex multicellularity

Hammarlund, E. U. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0101 · Cited by 25

Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside‐Down Microfluidic Devices

Hsu, H., Ko, P., Wu, H., Lin, H., Wang, C., & Tung, Y. (2021) · Small · doi:10.1002/smll.202006091 · Cited by 24

Flexible thread-based electrochemical sensors for oxygen monitoring

Xia, J., & Sonkusale, S. (2021) · The Analyst · doi:10.1039/d0an02400g · Cited by 24

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Ceranski, A. K., Carreño-Gonzalez, M. J., Ehlers, A. C., Colombo, M. V., Cidre‐Aranaz, F., & Grünewald, T. G. P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01750-w · Cited by 25

Human platelets release amyloid peptides β1-40 and β1-42 in response to hemostatic, immune, and hypoxic stimuli

Wolska, N., Celikag, M., Failla, A. V., Tarafdar, A., Renné, T., Torti, M., Canobbio, I., & Pula, G. (2023) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2023.100154 · Cited by 24

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Yang, Z., Li, P., Feng, W., & Chen, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202305866 · Cited by 26

Current challenges and opportunities in treating hypoxic prostate tumors

McKenna, D. J., Errington, R. J., & Pors, K. (2018) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2017.54 · Cited by 25

Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

Maurer, G. D., Heller, S., Wanka, C., Rieger, J., & Steinbach, J. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051061 · Cited by 24

Exploring chronic and transient tumor hypoxia for predicting the efficacy of hypoxia-activated pro-drugs

Mathur, S., Chen, S., & Rejniak, K. A. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00327-z · Cited by 23

Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Wang, J., Wang, J., Yu, Z., Wen, H., Zhao, C.-S., Zhong, J., Xiao, C., Li, Y., Xu, J., Wang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202411813 · Cited by 25

Cycling hypoxia selects for constitutive HIF stabilization

Pressley, M., Gallaher, J. A., Brown, J. S., Tomaszewski, M. R., Borad, P., Damaghi, M., Gillies, R. J., & Whelan, C. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-85184-8 · Cited by 23

Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology

Blagih, J., Hennequart, M., & Zani, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637960 · Cited by 25

Is Hypoxia a Factor Influencing PSMA-Directed Radioligand Therapy?—An In Silico Study on the Role of Chronic Hypoxia in Prostate Cancer

Birindelli, G., Drobnjaković, M., Morath, V., Steiger, K., D’Alessandria, C., Gourni, E., Afshar‐Oromieh, A., Weber, W., Rominger, A., Eiber, M., et al. (2021) · Cancers · doi:10.3390/cancers13143429 · Cited by 23

Immunotherapeutic targets in non‐small cell lung cancer

Sadeghirad, H., Bahrami, T., Layeghi, S. M., Yousefi, H., Rezaei, M., Hosseini‐Fard, S. R., Radfar, P., Warkiani, M. E., O'Byrne, K. J., & Kulasinghe, A. (2022) · Immunology · doi:10.1111/imm.13562 · Cited by 24

Radio-resistance of hypoxic tumors: exploring the effects of oxygen and X-ray radiation on non-small lung cancer cell lines

Hanley, R., Pagliari, F., García-Calderón, D., Guerreiro, J. F., Genard, G., Jansen, J., Nisticò, C., Marafioti, M. G., Tirinato, L., & Seco, J. C. (2023) · Radiation Oncology · doi:10.1186/s13014-023-02275-8 · Cited by 24

The Effect of GLUT1 and HIF-1α Expressions on Glucose Uptake and Patient Survival in Non-Small-Cell Lung Carcinoma

Kokeza, J., Strikić, A., Ogorevc, M., Kelam, N., Vukoja, M., Dilber, I., & Tomaš, S. Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310575 · Cited by 23

Alive attenuatedSalmonellaas a cargo shuttle for smart carrying of gold nanoparticles to tumour hypoxic regions

Kefayat, A., Ghahremani, F. H., Motaghi, H., Rostami, S., & Mehrgardi, M. A. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1523417 · Cited by 23

Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT

Matsuyama, M., WuWong, D. J., Horvath, S., & Matsuyama, S. (2019) · Aging · doi:10.18632/aging.101955 · Cited by 24

Generation of singlet oxygen inside living cells: correlation between phosphorescence decay lifetime, localization and outcome of photodynamic action

Szewczyk, G. M., Mokrzynski, K. T., & Sarna, T. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-024-00620-8 · Cited by 22

UVC-Emitting LuPO4:Pr3+ Nanoparticles Decrease Radiation Resistance of Hypoxic Cancer Cells

Müller, M., Espinoza, S., Jüstel, T., Held, K. D., Anderson, R. R., & Purschke, M. (2019) · Radiation Research · doi:10.1667/rr15491.1 · Cited by 22

Under‐Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle‐Based Approach for Microscale Cell Culture

Li, C., Humayun, M., Walker, G. M., Park, K. Y., Connors, B., Feng, J., Pellitteri-Hahn, M. C., Scarlett, C. O., Li, J., Feng, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202104510 · Cited by 22

Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay

Ishkaeva, R. A., Zoughaib, M., Laikov, A. V., Angelova, P. R., & Abdullin, T. I. (2022) · Antioxidants · doi:10.3390/antiox11020391 · Cited by 23

Recapitulating Tumor Hypoxia in a Cleanroom-Free, Liquid-Pinning-Based Microfluidic Tumor Model

Oh, J. M., Begum, H. M., Liu, Y. L., Ren, Y., & Shen, K. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00207 · Cited by 22

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Zhang, X., Yu, C., Zhao, S., Wang, M., Shang, L., Zhou, J., & Ma, Y. (2023) · Cancer Medicine · doi:10.1002/cam4.6717 · Cited by 24

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

Kim, C. H., Lee, E. S., Ko, H., Son, S., Kim, S. H., Lee, C. H., Na, H., Shin, J. M., & Park, J. H. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c02472 · Cited by 22

Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade

Benzarti, M., Delbrouck, C., Neises, L., Kiweler, N., & Meiser, J. (2020) · Cells · doi:10.3390/cells9092035 · Cited by 21

3D-Printed Oxygen-Carrying Nanocomposite Hydrogels for Enhanced Cell Viability under Hypoxic and Normoxic Conditions

Motealleh, A., Schäfer, A. H., Fromm, O., & Kehr, N. S. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c01067 · Cited by 22

Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer

Kumano, K., Nakahashi, H., Louphrasitthiphol, P., Kuroda, Y., Miyazaki, Y., Shimomura, O., Hashimoto, S., Akashi, Y., Mathis, B. J., Kim, J., et al. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1327772 · Cited by 21

Transcription Factors and Methods for the Pharmacological Correction of Their Activity

Guryanova, S. V., Maksimova, T. V., & Мухамедовна, А. М. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136394 · Cited by 23

Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation

Foglia, B., Sutti, S., Cannito, S., Rosso, C., Maggiora, M., Autelli, R., Novo, E., Bocca, C., Villano, G., Ramavath, N. N., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.10.002 · Cited by 22

Current developments in modelling the tumour microenvironment in vitro: Incorporation of biochemical and physical gradients

Ahmed, M. A. M., & Nagelkerke, A. (2021) · Organs-on-a-Chip · doi:10.1016/j.ooc.2021.100012 · Cited by 24

Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma

Onken, M. D., Noda, S. E., Kaltenbronn, K. M., Frankfater, C., Makepeace, C. M., Fettig, N., Piggott, K., Custer, P. L., Ippolito, J. E., & Blumer, K. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101495 · Cited by 21

MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer

Angel, C. Z., Stafford, M. Y. C., McNally, C. J., Nesbitt, H., & McKenna, D. J. (2023) · Cancers · doi:10.3390/cancers15041291 · Cited by 22

Targeting Active Cancer Cells With Smart Bullets

Martel, S. M. (2017) · Therapeutic Delivery · doi:10.4155/tde-2016-0088 · Cited by 21

Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)

Calder, E. D. D., Skwarska, A., Sneddon, D., Folkes, L. K., Mistry, I. N., Conway, S. J., & Hammond, E. M. (2020) · Tetrahedron · doi:10.1016/j.tet.2020.131170 · Cited by 21

Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α

Juhász, K. Z., Hajdú, T., Kovács, P., Vágó, J., Matta, C., & Takács, R. (2024) · Cells · doi:10.3390/cells13060512 · Cited by 20

3D stem-like spheroids-on-a-chip for personalized combinatorial drug testing in oral cancer

Mehta, V., Sudhakaran, S. V., Nellore, V., Madduri, S., & Rath, S. N. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02625-y · Cited by 21

Extracellular vesicles and the tumour microenvironment

Belényesi, S.-K., Patmore, S., & O’Driscoll, L. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189275 · Cited by 20

Role of hyperoxic treatment in cancer

Kim, S. W., Kim, I. K., & Lee, S. H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220921547 · Cited by 20

Mild chronic hypoxia-induced HIF-2α interacts with c-MYC through competition with HIF-1α to induce hepatocellular carcinoma cell proliferation

Mu, H., Ge, Y. P., Li, H., Wang, M., Cui, Y., Zhang, T., Song, T., & Liu, C. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00625-w · Cited by 23

GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors

Ryniawec, J. M., Coope, M. R., Loertscher, E., Bageerathan, V., Pessôa, D. D. O., Warfel, N. A., Cress, A. E., Padi, M., & Rogers, G. C. (2022) · Diagnostics · doi:10.3390/diagnostics12030676 · Cited by 20

Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3

Gong, W., Guo, Y., Yuan, H., Chai, R., Wan, Z., Zheng, B., Hu, X., Chen, B., Gao, S., Dai, Q., et al. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00591-5 · Cited by 23

Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model

Samuel, T., Rapic, S., O’Brien, C., Edson, M., Zhong, Y., & DaCosta, R. S. (2023) · Science Advances · doi:10.1126/sciadv.ade8672 · Cited by 20

Ahypoxia-related signature enhances the prediction of the prognosis in hepatocellular carcinoma patients and correlates with sorafenib treatment response.

Jiang, H., Ning, G., Wang, Y., & Lv, W. (2020) · Europe PMC (PubMed Central) · Cited by 20

Analysis of the Internal Hypoxic Environment in Solid Tumor Tissue Using a Folding Paper System

Huang, C., Chong, K., & Lei, K. F. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c08857 · Cited by 20

Hypoxia modulates CCR7 expression in head and neck cancers

Basheer, H. A., Pakanavicius, E., Cooper, P. A., Shnyder, S. D., Martin, L., Hunter, K. D., Vinader, V. M., & Afarinkia, K. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.03.014 · Cited by 22

Obstructive Sleep Apnea and Pathological Characteristics of Resected Pancreatic Ductal Adenocarcinoma

Dal Molin, M., Brant, A., Blackford, A. L., Griffin, J. F., Shindo, K., Barkley, T., Rezaee, N., Hruban, R. H., Wolfgang, C. L., & Goggins, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0164195 · Cited by 19

Patient-specific prostate tumour growth simulation: a first step towards the digital twin

Pérez-Benito, Á., García‐Aznar, J. M., Gómez‐Benito, M. J., & Pérez, M. Á. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1421591 · Cited by 19

Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

Murphy, R. J., Gunasingh, G. P., Haass, N. K., & Simpson, M. J. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010833 · Cited by 19

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Werschler, N., & Penninger, J. M. (2023) · Journal of Visualized Experiments · doi:10.3791/64715 · Cited by 19

Oxygen concentration modulates colibactin production

Bossuet‐Greif, N., Guyonnet, C., Chagneau, C. V., Tang-Fichaux, M., Pénary, M., Loubet, D., Branchu, P., Oswald, É., & Nougayrède, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2222437 · Cited by 21

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia

Ježek, J., Plecitá‐Hlavatá, L., & Ježek, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00637 · Cited by 20

Carbonic anhydrase III is a new target of HIF1α in prostate cancer model

Okuyan, D., Türkoğlu, S. A., & KOCKAR, F. T. (2020) · Gene · doi:10.1016/j.gene.2020.145034 · Cited by 19

Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1α in endothelial cells

Altuntaş, C., Alper, M., Keleş, Y., Sav, F. N., & KOCKAR, F. T. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04549-3 · Cited by 19

Hypoxia Exacerbation-Triggered Doxorubicin Prodrug Activation for Sequential Photodynamic/Chemotherapy

Li, H., Zhang, X., Chen, S., Cao, C., Zhang, X., Li, X., Xing, S., Jia, S., Li, J., & Wang, S. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c00798 · Cited by 18

The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies

Bou-Gharios, J., Noël, G., & Burckel, H. (2024) · BMC Biology · doi:10.1186/s12915-024-02075-w · Cited by 18

Interaction of Artepillin C with model membranes: Effects of pH and ionic strength

Pazin, W. M., Ruiz, G. C. M., Oliveira, O. N., & Constantino, C. J. L. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.11.008 · Cited by 18

Three-Dimensional, Scaffolded Tumor Model to Study Cell-Driven Microenvironment Effects and Therapeutic Responses

Ornell, K. J., Mistretta, K. S., Newman, E. A., Ralston, C. Q., & Coburn, J. M. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01267 · Cited by 18

Growing human trophoblasts in vitro : a review of the media commonly used in trophoblast cell culture

Nursalim, Y. N. S., Blenkiron, C., Groom, K. M., & Chamley, L. W. (2020) · Reproduction · doi:10.1530/rep-19-0605 · Cited by 18

Chorioretinal Hypoxia Detection Using Lipid-Polymer Hybrid Organic Room-Temperature Phosphorescent Nanoparticles

Zeng, Y., Nguyen, V. P., Li, Y., Kang, D. H., Paulus, Y. M., & Kim, J. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02767 · Cited by 19

Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions

Subasinghe, S. A. A. S., Pautler, R. G., Samee, M. A. H., Yustein, J. T., & Allen, M. J. (2022) · Biosensors · doi:10.3390/bios12070478 · Cited by 18

Histone acetyltransferase 1 (HAT1) acetylates hypoxia-inducible factor 2 alpha (HIF2A) to execute hypoxia response

Kumar, N., Mondal, M., Arathi, B. P., Sundaresan, N. R., & Somasundaram, K. (2022) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2022.194900 · Cited by 19

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Coates, H. W., Capell-Hattam, I. M., Olzomer, E. M., Du, X., Farrell, R., Yang, H., Byrne, F. L., & Brown, A. J. (2022) · eLife · doi:10.7554/elife.82843 · Cited by 22

The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung

Mathur, D., Liao, C., Lin, W., Ferlita, A. L., Alaimo, S., Taylor, S. R., Zhong, Y., Iacobuzio–Donahue, C. A., Ferro, A., & Xavier, J. B. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0153 · Cited by 18

Infantile Hemangioma: A Cross-Sectional Observational Study

Şandru, F., Turenschi, A., Constantin, A. T., Dinulescu, A., Radu, A.-M., & Roșca, I. (2023) · Life · doi:10.3390/life13091868 · Cited by 18

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Kaur, B., Scavuzzi, B. M., Abcouwer, S. F., & Zacks, D. N. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109653 · Cited by 18

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Li, Z., Zhang, W., Guo, S., Qi, G., Huang, J., Gao, J., Zhao, J., Kang, L., & Li, Q. (2024) · Cancer Control · doi:10.1177/10732748241299072 · Cited by 22

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Alhaddad, L., Osipov, A. N., & Leonov, S. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312506 · Cited by 22

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1

Leszczyńska, K. B., Göttgens, E., Biasoli, D., Olcina, M. M., Ient, J., Anbalagan, S., Bernhardt, S., Giaccia, A. J., & Hammond, E. M. (2016) · Scientific Reports · doi:10.1038/srep21698 · Cited by 21

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246

Hypoxia/Normoxia

(2005) · Springer eBooks · doi:10.1007/3-540-29623-9_7440 · Cited by 2

The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic

Hammond, E. M., Asselin, M., Forster, D. M., O’Connor, J. P. B., Senra, J. M., & Williams, K. J. (2014) · Clinical Oncology · doi:10.1016/j.clon.2014.02.002 · Cited by 227

Tumor Oxygenation and Treatment Response

Lunt, S. J., & Hill, R. P. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-035-5_3

Measurement of tumor oxygenation

Horsman, M. R. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00332-0 · Cited by 92