The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Noncoding RNA and Polycomb recruitment
Open accessAbstract
A plethora of noncoding (nc) RNAs has been revealed through the application of high-throughput analysis of the transcriptome, and this has led to an intensive search for possible biological functions attributable to these transcripts. A major category of functional ncRNAs that has emerged is for those that are implicated in coordinate gene silencing, either in cis or in trans. The archetype for this class is the well-studied long ncRNA Xist which functions in cis to bring about transcriptional silencing of an entire X chromosome in female mammals. An important step in X chromosome inactivation is the recruitment of the Polycomb repressive complex PRC2 that mediates histone H3 lysine 27 methylation, a hallmark of the inactive X chromosome, and recent studies have suggested that this occurs as a consequence of PRC2 interacting directly with Xist RNA. Accordingly, other ncRNAs have been linked to PRC2 targeting either in cis or in trans, and here also the mechanism has been proposed to involve direct interaction between PRC2 proteins and the different ncRNAs. In this review, I discuss the evidence for and against this hypothesis, in the process highlighting alternative models and discussing experiments that, in the future, will help to resolve existing discrepancies.
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1 retracted
Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax
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“REST corepressor complex (Tsai et al. 2010).”
Background
Cited by
Histone Deacetylase Inhibitors as Anticancer Drugs
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The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites
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How do lncRNAs regulate transcription?
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lncRNAs and microRNAs with a role in cancer development
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Metadata
- Authors
- Brockdorff, N.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-19
- Volume
- 19
- Issue
- 4
- Pages
- 429-442
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2141624808
- Cited by
- 285
- References
- 101
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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