The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers
Open accessAbstract
A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.
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“These first inefficient ribozymes could then ‘jump-start’ the evolution of sequences with greater function and complexity through natural selection, especially within a spatially restricted context (44,63,68).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [44]
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2 retracted
RNA-Mediated Metal-Metal Bond Formation in the Synthesis of Hexagonal Palladium Nanoparticles
Gugliotti, L. A., Feldheim, D. L., & Eaton, B. E. (2004) · Science · doi:10.1126/science.1095678 · Cited by 197
RetractedRETRACTED: RNA-Mediated Synthesis of Palladium Nanoparticles on Au Surfaces
Liu, D., Gugliotti, L. A., Wu, T. S., Dolska, M., Ткаченко, А. Г., Shipton, M. K., Eaton, B. E., & Feldheim, D. L. (2006) · Langmuir · doi:10.1021/la060426c · Cited by 37
RetractedSelforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
Gilbert, W. (1986) · Nature · doi:10.1038/319618a0 · Cited by 2,721
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SELEX—A (r)evolutionary method to generate high-affinity nucleic acid ligands
Stoltenburg, R., Reinemann, C., & Strehlitz, B. (2007) · Biomolecular Engineering · doi:10.1016/j.bioeng.2007.06.001 · Cited by 1,485
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Leslie E., O. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490460765 · Cited by 1,124
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Joyce, G. F. (2002) · Nature · doi:10.1038/418214a · Cited by 1,070
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Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division
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Prebiological Organization of Molecules in Models and in the Matter of the Origin of Life
Zhogol, R. A., & . (2018) · International Journal of Engineering & Technology · doi:10.14419/ijet.v7i3.14.17044
Isoxazol‐Nukleoside als Bausteine für eine plausible Proto‐RNA
Xu, F., Crisp, A. L., Schinkel, T., Dubini, R. C. A., Hübner, S., Becker, S. M., Schelter, F., Rovó, P., & Carell, T. (2022) · Angewandte Chemie · doi:10.1002/ange.202211945
Paczkó, M., Szathmáry, E., & Szilágyi, A. (2024) · eLife · doi:10.7554/elife.93208.1
Epigenetics Integrates Development, Signaling, Context, RNA-Networks and Evolution
Witzany, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_1
Alejandre, C., Fernández-Ruz, M., Guantes, R., & Aguirre, J. (2026) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2026.100588
Exploration of the evolutionary potential of random RNA mixtures in the presence of catalytic RNA
Pavlinova, P. (2024) · theses.fr (ABES) · doi:10.70675/d7ccf328zdd57z4a26za426z2d0498b9b3b5
Prinz, R., & Witzany, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-24295-2_20
The maintenance and emergence of diversity promotes open-ended evolution in a pre-cellular system
Kalambokidis, M., Medina-Chávez, N. O., Khey, J., & Travisano, M. (2026) · npj Complexity · doi:10.1038/s44260-026-00072-4
Conrad, B., Iseli, C., & Pirovino, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.25.740712
Reading the ribosome critically: A palindrome hypothesis and the limits of molecular inference
Petrov, A. S. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2624727123
Metadata
- Authors
- Briones, C., Stich, M., & Manrubia, S. C.
- Affiliations
- Centro de Astrobiología (ES)
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-03-24
- Volume
- 15
- Issue
- 5
- Pages
- 743-749
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- PMC
- PMC2673073
- OpenAlex
- W2127447806
- Cited by
- 114
- References
- 61
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 11 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 9
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- RNA (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Indian National Science Academy
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA world, origin of life, RNA oligomers, mineral surfaces, ribozyme evolution, RNA replicase, hairpin structure, Darwinian evolution
- MeSH terms
- Origin of Life, Nucleic Acid Conformation, RNA, Catalytic, Evolution, Molecular, Inverted Repeat Sequences
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