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The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers
Open accessAbstract
A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually functional RNA molecules retaining their previous modular structure: molecular complexity increases but template replication is absent. This allows us to build up a stepwise model of ligation-based, modular evolution that could pave the way to the emergence of a ribozyme with RNA replicase activity, step at which information-driven Darwinian evolution would be triggered.
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“These first inefficient ribozymes could then ‘jump-start’ the evolution of sequences with greater function and complexity through natural selection, especially within a spatially restricted context (44,63,68).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [44]
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Self-citation
Metadata
- Authors
- Briones, C., Stich, M., & Manrubia, S. C.
- Affiliations
- Centro de Astrobiología (ES)
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-03-24
- Volume
- 15
- Issue
- 5
- Pages
- 743-749
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- PMC
- PMC2673073
- OpenAlex
- W2127447806
- Cited by
- 114
- References
- 61
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 11 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 9
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- RNA (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Indian National Science Academy
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA world, origin of life, RNA oligomers, mineral surfaces, ribozyme evolution, RNA replicase, hairpin structure, Darwinian evolution
- MeSH terms
- Origin of Life, Nucleic Acid Conformation, RNA, Catalytic, Evolution, Molecular, Inverted Repeat Sequences
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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