The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans
Open accessAbstract
C. elegans contains numerous small RNAs of ~21–24 nt in length. The microRNAs (miRNAs) are small noncoding RNAs produced by DCR-1- and ALG-dependent processing of self-complementary hairpin transcripts. Endogenous small interfering RNAs (endo-siRNAs), associated with ongoing silencing of protein-coding genes in normal worms, are produced by mechanisms that involve DCR-1 but, unlike miRNAs, also involve RDE-2, RDE-3, RDE-4, RRF-1, and RRF-3. The tiny noncoding (tncRNAs) are similar to endo-siRNAs in their biogenesis except that they are derived from noncoding sequences. These endo-siRNA- and tncRNA-based endogenous RNAi pathways involve some components, including DCR-1 and RDE-4, that are shared with exogenous RNAi, and some components, including RRF-3 and ERI-1, that are specific to endogenous RNAi. rrf-3 and eri-1 mutants are enhanced for some silencing processes and defective for others, suggesting cross-regulatory interactions between RNAi pathways in C. elegans . Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Self-citationKetting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,852
Cited by
Specialization and evolution of endogenous small RNA pathways
Chapman, E. J., & Carrington, J. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2179 · Cited by 696
Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans
Rechavi, O., Houri-Ze’evi, L., Anava, S., Goh, W. S. S., Kerk, S. Y., Hannon, G. J., & Hobert, O. (2014) · Cell · doi:10.1016/j.cell.2014.06.020 · Cited by 552
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
Pak, J., & Fire, A. (2007) · Science · doi:10.1126/science.1132839 · Cited by 599
An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus
Guang, S., Bochner, A. F., Pavelec, D. M., Burkhart, K. B., Harding, S., Lachowiec, J., & Kennedy, S. (2008) · Science · doi:10.1126/science.1157647 · Cited by 351
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
Calabrese, J. M., Seila, A. C., Yeo, G. W., & Sharp, P. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709193104 · Cited by 320
Metadata
- Authors
- LEE, R. C., HAMMELL, C. M., & AMBROS, V.
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-02-17
- Volume
- 12
- Issue
- 4
- Pages
- 589-597
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- OpenAlex
- W2124774982
- Cited by
- 202
- References
- 2
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. https://app.cochat.ai/papers/10.1261/rna.2231506
- The paper
- LEE, R. C., HAMMELL, C. M., & AMBROS, V. (2006). Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. RNA. https://doi.org/10.1261/rna.2231506
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
