The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Florid Interstitial Hemorrhages: A Novel Feature of Amoxicillin-Clavulanate-Induced Acute Tubulointerstitial Nephritis
Open accessAbstract
BACKGROUND Acute tubulointerstitial nephritis is most often induced by drug therapy and is characterized by the presence of edema, inflammatory infiltrates, and sometimes granulomas within the interstitium. We report this case to describe florid interstitial hemorrhages as a novel feature of Amoxicillin-Clavulanate-induced acute tubulointerstitial nephritis. CASE REPORT A young man presented with intermittent visible hematuria and acute kidney injury after a course of Amoxicillin-Clavulanate for upper respiratory tract illness. Renal biopsy demonstrated acute tubulointerstitial nephritis with multifocal intense interstitial hemorrhages, intratubular red blood cells, and red blood cell casts. At the same time, he was diagnosed with acute lymphoblastic leukemia. Leukemic cellular infiltration and other potential causes of tubulointerstitial nephritis were ruled out. CONCLUSIONS Drug-induced tubulointerstitial nephritis can be associated with florid interstitial hemorrhages. This can lead to an atypical clinicopathological presentation of tubulointerstitial nephritis, masquerading as glomerulonephritis, vasculitis, or infectious interstitial nephritis.
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“Asim et al. [76] presented a case of hemorrhagic tubulointerstitial nephritis caused by amoxicillin–clavulanate, characterized by systemic eosinophilia, a high concentration of eosinophils and plasma cells in the interstitial infiltrate, indicating a delayed hypersensitivity immune response mediated by antigen-reactive T cells.”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [76]
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González, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., et al. (2008) · Kidney International · doi:10.1038/sj.ki.5002776 · Cited by 466
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Muhammad, A., Zhang, Y., Huang, L., Yuan, Q., Wang, W., Pu, J., Lin, W., Tang, R., & Xiao, X. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae054 · Cited by 13
“[76 ] presented a case of hemorrhagic tubulointerstitial nephritis caused by amoxicillin–clavulanate, characterized by systemic eosinophilia, a high concentration of eosinophils and plasma cells in the interstitial infiltrate, indicating a delayed hypersensitivity immune response mediated by…”
Background
Metadata
- Authors
- Asim, M., Ahmad, F., & Akhtar, M.
- Affiliations
- Hamad General Hospital (QA)
- Corresponding author
- Asim, Muhammad
- Venue
- American Journal of Case Reports
- Published
- 2021-02-04
- Volume
- 22
- Pages
- e928989-e928989
- ISSN
- 1941-5923 (ISSN-L)
- PMC
- PMC7980086
- OpenAlex
- W3127722598
- Cited by
- 4
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- American Journal of Case Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Keywords
- acute interstitial nephritis, drug-induced nephrotoxicity, amoxicillin-clavulanic acid, interstitial hemorrhage, acute kidney injury, hematuria, red blood cell casts, acute lymphoblastic leukemia, renal biopsy findings
- MeSH terms
- Amoxicillin, Glomerulonephritis, Humans, Male, Nephritis, Interstitial, Clavulanic Acid
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