Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients
Open accessAbstract
BACKGROUND: The main mechanism underlying irritable bowel syndrome is currently believed to be a dysfunction of the brain-gut axis. Autonomic nervous system dysfunction can contribute to development of irritable bowel syndrome symptoms by disturbing visceral sensations. MATERIAL/METHODS: Thirty patients with a diagnosis of constipation-predominant irritable bowel syndrome and 30 healthy volunteers were included in the study. Resting and functional autonomic nervous system tests and percutaneous electrogastrography were performed. Plasma adrenalin, noradrenalin, insulin, ghrelin and cholecystokinin activity was analyzed. RESULTS: Increased sympathetic activation with disturbed parasympathetic function was demonstrated. Patients had substantially higher plasma catecholamine concentration, which confirms sympathetic overbalance. Hyperinsulinemia may explain sympathetic predominance followed by gastric and intestinal motility deceleration. Abnormal, reduced ghrelin and cholecystokinin titre may disturb brain-gut axis functioning and may be responsible for gastric motility deceleration. In electrogastrography, distinctly lower values of fasting normogastria percentage and dominant power were observed. Patients had substantially lower slow wave coupling percentage both in fasting and postprandial periods, which negatively correlated with plasma catecholamines level. Gastric myoelectrical activity disturbances may result from lack of sympatho-parasympathetic equilibrium. CONCLUSIONS: Central sympathetic influence within the brain-gut axis is most probably responsible for myoelectrical activity disturbances in irritable bowel syndrome patients.
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In a previous study, IBS-C patients had lower HF power and a higher LF/HF ratio than healthy controls, which suggests parasympathetic dysfunction and sympathetic overactivity.
“In a previous study, IBS-C patients had lower HF power and a higher LF/HF ratio than healthy controls, which suggests parasympathetic dysfunction and sympathetic overactivity.3,5”
HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.
“HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.”
Mazur et al. showed that HF power was significantly lower and the LF/HF ratio was significantly higher in IBS-C patients than in a non-IBS control group.
“Mazur et al3 showed that HF power was significantly lower and the LF/HF ratio was significantly higher in IBS-C patients than in a non-IBS control group.”
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Wolde, H. M., Jung, H., Kim, H., Shin, W.-S., Lee, S. W., & Bae, Y. (2026) · doi:10.2196/preprints.99751
Rejili, M., Mustafa, A. M., Al-Kuraishy, H. M., Hussein, N. R., Al-Maiahy, T. J., Al-Gareeb, A. I., Albuhadily, A. K., & Batiha, G. E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05419-1
Erickson, J. C., Paige, L., Gipson, J., Gresham, N., & Dinning, P. G. (2026) · medRxiv · doi:10.64898/2026.06.02.26354686
- Authors
- Mazur, M., Furgała, A., Jabłoński, K., Mach, T., & Thor, P.
- Affiliations
- Jagiellonian University (PL)
- Corresponding author
- Mazur, Marcel
- Venue
- Medical Science Monitor
- Published
- 2012
- Volume
- 18
- Issue
- 8
- Pages
- CR493-CR499
- ISSN
- 1234-1010 (ISSN-L)
- PMC
- PMC3560712
- OpenAlex
- W2057308052
- Cited by
- 59
- References
- 49
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 5 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Medical Science Monitor (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome with constipation, autonomic dysfunction, gut-brain axis, sympathetic hyperactivity, parasympathetic dysfunction, plasma catecholamines, hyperinsulinemia, ghrelin, cholecystokinin, electrogastrography, gastric myoelectrical activity, visceral sensation
- MeSH terms
- Adult, Autonomic Nervous System, Catecholamines, Constipation, Electromyography, Fasting, Feeding Behavior, Female, Gastrointestinal Hormones, Heart Rate, Humans, Male, Respiration, Case-Control Studies, Irritable Bowel Syndrome
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