Cited by 355Stress Responses and CortisolAdrenal Hormones and DisordersCircadian rhythm and melatonin

Cortisol pulsatility and its role in stress regulation and health

YOUNG, E, ABELSON, J, LIGHTMAN, S·2004·Frontiers in Neuroendocrinology

Abstract

One of the classic characteristics of the human stress response is the wide inter-individual variation. Although there is much current interest in the genetic and environmental contributions to these differences, studies on human subject have been sparse and characterised by methodological problems. The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo-pituitary-adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes. In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease.

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Crossref · 10.1016/j.yfrne.2004.07.001

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Authors
YOUNG, E., ABELSON, J., & LIGHTMAN, S.
Affiliations
  • University of Michigan (US)
  • Bristol Royal Infirmary (GB)
Corresponding author
YOUNG, E
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2004-07
Volume
25
Issue
2
Pages
69-76
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2075627423
Cited by
355
References
28
Citations by year
2026: 8 · 2025: 10 · 2024: 8 · 2023: 15 · 2022: 15 · 2021: 15 · 2020: 19 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 23 · 2015: 26 · 2014: 21 · 2013: 33 · 2012: 15
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
  • National Institute of Mental Health (MH 52724, MH 01931, R01MH050030, MH50030, K05MH001931)
  • National Center for Research Resources (M-01RR00042, M01RR000042)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
hypothalamic-pituitary-adrenal axis, stress response, interindividual variability, diurnal cortisol rhythm
MeSH terms
Animals, Circadian Rhythm, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Periodicity, Pituitary-Adrenal System, Pulsatile Flow, Stress, Physiological

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