Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy

Wang, Jie; Wang, Yajun; Xu, Xudong; Peng, Sheng; Xu, Feng; Liu, Peirong

doi:10.12659/msm.922028

Cited by 81Treatment of Major DepressionAnesthesia and Pain ManagementCancer, Stress, Anesthesia, and Immune Response

Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy

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Wang, Jie, Wang, Yajun, Xu, Xudong, Peng, Sheng, Xu, Feng, Liu, Peirong·2020·Medical Science Monitor

DOI 10.12659/msm.922028PMC PMC7331479

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Abstract

BACKGROUND This study investigated the effects of various doses of S-ketamine on depression and pain management of cervical carcinoma patients with mild/moderate depression. MATERIAL AND METHODS This randomized, double-blind, controlled study included 417 cervical carcinoma patients who received laparoscopic modified radical hysterectomy from April 2015 to July 2018 and who also had mild/moderate depression symptoms based on HAMD-17 scores (8~24). All patients were randomized into 4 groups: 1) the control group, 2) the racemic ketamine group, 3) the high-dose S-ketamine group; and 4) the low-dose S-ketamine group. Pain was assessed using the Visual Analogue Score (VAS), and depression was assessed using theHAMD-17 score. Serum levels of BDNF and 5-HT were measured. RESULTS The 4 groups of patients showed no significant differences in operation time, bleeding volume, hospitalization duration, or complications. The high-dose S-ketamine group showed significantly lower VAS and HAMD-17 scores than all other groups at 1 day and 3 days postoperatively, but no differences were observed in the low-dose S-ketamine group and the racemic ketamine group. The high-dose S-ketamine group showed significantly higher serum BDNF and 5-HT levels at 1 day and 3 days after surgery. However, 1 week after surgery, no difference was observed in any of the treatment groups. CONCLUSIONS At subanesthetic dose, both 0.5 mg/kg and 0.25 mg/kg S-ketamine improved short-term depression and pain for cervical carcinoma patients after surgery, and the effects were better than with the same dose of racemic ketamine.

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In Wang et al. (2020), after 5 and 7 days, depression scores were low in all four groups with no significant between-group differences.
“After 5 and 7 days, depression scores were low in all four groups with no significant between-group differences.”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Wang et al., 2020
The Results section, “Comparison of HAMD-17 scores” (page not provided), reports no significant difference among the four groups at day 5. The copy does not establish that depression scores were low at days 5 and 7; its statement that there was no difference at one week appears in the abstract, not in the full-text Results passage on HAMD-17 scores. (LLM, conf=0.82)
Experimental — accuracy not yet measured
In Wang et al. (2020), depression scores after 1, 2, and 3 days decreased significantly more in all ketamine treatment groups than in the control group.
“Depression scores after 1, 2, and 3 days decreased significantly more in all treatment groups than in the control group.”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Wang et al., 2020
In Wang et al. (2020), the decrease was highest for the high-dose S-ketamine group, with no significant difference between the racemic and low-dose S-ketamine groups.
“This decrease was highest for the high-dose S-ketamine group, while no significant difference was found between the racemic and low-dose S-ketamine groups.”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Wang et al., 2020
Two studies from the same research group found S-ketamine superior to racemic ketamine in treating pain and depression.
“Two studies from the same research group (Liu et al., 2020;Wang et al., 2020) compared racemic and S-ketamine and found S-ketamine to be superior to racemic ketamine in treating pain and depression”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Wang et al., 2020
Esketamine studies on BDNF have been conducted in special populations such as postpartum depression and surgical patients.
“For esketamine, studies have been conducted in special populations, such as patients with postpartum depression [104] or those who have undergone surgery [99,105].”
From Variations in BDNF and Their Role in the Neurotrophic Antidepressant Mechanisms of Ketamine and Esketamine: A Review (2024) · cites this paper as [99]

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Cervical cancer: A global health crisis
Small, W. C., Bacon, M. A., Bajaj, A., Chuang, L. T., Fisher, B. J., Harkenrider, M. M., Jhingran, A., Kitchener, H. C., Mileshkin, L., Viswanathan, A. N., et al. (2017) · Cancer · doi:10.1002/cncr.30667 · Cited by 1,180 · see citing works
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
aan het Rot, M., Collins, K. A., Murrough, J. W., Perez, A. M., Reich, D. L., Charney, D. S., & Mathew, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.038 · Cited by 690 · see citing works
Major depression after breast cancer: a review of epidemiology and treatment
Fann, J. R., Thomas-Rich, A. M., Katon, W. J., Cowley, D., Pepping, M., McGregor, B. A., & Gralow, J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.10.008 · Cited by 586 · see citing works
Depression and postoperative complications: an overview
Ghoneim, M. M., & O’Hara, M. W. (2016) · BMC Surgery · doi:10.1186/s12893-016-0120-y · Cited by 491 · see citing works
Quantitative MRI of the hippocampus and amygdala in severe depression
Mervaala, E., Föhr, J., Könönen, M., Valkonen‐Korhonen, M., Vainio, P. A., Partanen, K. P. L., Partanen, J. V., Tiihonen, J., Viinamäki, H. T., Karjalainen, A.-M., et al. (2000) · Psychological Medicine · doi:10.1017/s0033291799001567 · Cited by 382 · see citing works
Cervical cancer prevention and treatment research in Africa: a systematic review from a public health perspective
Finocchario‐Kessler, S., Wexler, C., Maloba, M., Mabachi, N. M., Ndikum-Moffor, F. M., & Bukusi, E. A. (2016) · BMC Women s Health · doi:10.1186/s12905-016-0306-6 · Cited by 215 · see citing works
A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats
Wang, J., Goffer, Y., Xu, D., Tukey, D. S., Shamir, D. B., Eberle, S. E., Zou, A., Blanck, T. J. J., & Ziff, E. B. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31822f16ae · Cited by 172 · see citing works
Self-citation
The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis
Yang, Y.-L., Liu, L., Wang, Y., Wu, H., Yang, X.-S., Wang, J.-N., & Wang, L. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-393 · Cited by 165 · see citing works
Self-citation
Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression
Ye, Y., Wang, G., Wang, H., & Wang, X. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.055 · Cited by 131 · see citing works
Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients: Effects of exercise in breast cancer
Ergun, M., Eyigor, S., Karaca, B., Kisim, A., & Uslu, R. (2013) · European Journal of Cancer Care · doi:10.1111/ecc.12068 · Cited by 127 · see citing works
Psychiatric safety of ketamine in psychopharmacology research
Perry, E. B., Cramer, J. A., Cho, H.-S., Petrakis, I. L., Karper, L. P., Genovese, A., O’Donnell, E., Krystal, J. H., D’Souza, D. C., & Yale Ketamine Study Group (2007) · Psychopharmacology · doi:10.1007/s00213-007-0706-2 · Cited by 117 · see citing works
Prevalence and associated positive psychological variables of depression and anxiety among Chinese cervical cancer patients: a cross-sectional study
Yang, Y.-L., Liu, L., Wang, X.-X., Wang, Y., & Wang, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094804 · Cited by 108 · see citing works
Self-citation
Cervical cancer prevention and treatment in Latin America
Varón, M. L., Baker, E., Maza, M., Fontes‐Cintra, G., López, A., Carvajal, J. M., Nozar, F., Fiol, V., & Schmeler, K. M. (2017) · Journal of Surgical Oncology · doi:10.1002/jso.24544 · Cited by 105 · see citing works
Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways
Zuo, D., Lin, L., Liu, Y., Wang, C., Xu, J., Sun, F., Li, L., Li, Z., & Wu, Y. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9611-y · Cited by 99 · see citing works
Comparison of racemic ketamine andS-ketamine in treatment-resistant major depression: Report of two cases
Paul, R. H., Schaaff, N., Padberg, F., Möller, H., & Frodl, T. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701714370 · Cited by 98 · see citing works
Effects of S-Ketamine as an Anesthetic Adjuvant to Propofol on Treatment Response to Electroconvulsive Therapy in Treatment-Resistant Depression
Järventausta, K., Chrapek, W., Kampman, O., Tuohimaa, K., Björkqvist, M., Häkkinen, H., Yli‐Hankala, A., & Leinonen, E. V. J. (2013) · Journal of Ect · doi:10.1097/yct.0b013e318283b7e9 · Cited by 97 · see citing works
Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study
Woodhead, C., Cunningham, R., Ashworth, M. J., Barley, E. A., Stewart, R. J., & Henderson, M. J. (2016) · BMC Cancer · doi:10.1186/s12885-016-2842-8 · Cited by 74 · see citing works
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series
Paslakis, G., Gilles, M., Meyer‐Lindenberg, A., & Deuschle, M. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1237375 · Cited by 66 · see citing works
Repeated S‐ketamine Infusions in Therapy Resistant Depression: A Case Series
Segmiller, F. M., Rüther, T., Linhardt, A., Padberg, F., Berger, M., Pogarell, O. M., Möller, H., Kohler, C., & Schüle, C. (2013) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.122 · Cited by 65 · see citing works
Cervical Cancer: A Global Health Crisis
Small, W. C., Bacon, M. A., Bajaj, A., Chuang, L. T., Fisher, B. J., Harkenrider, M. M., Jhingran, A., Kitchener, H. C., Mileshkin, L., Viswanathan, A. N., et al. (2017) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000526010.06041.5e · Cited by 54 · see citing works
Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine
Larenza, M. P., Knobloch, M., Landoni, M. F., Levionnois, O., Kronen, P., Theurillat, R., Schatzmann, U., & Thormann, W. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.05.005 · Cited by 38 · see citing works
S-ketamine versus racemic ketamine in dogs: their relative potency as induction agents
Casoni, D. C., Spadavecchia, C., & Adami, C. (2014) · Veterinary Anaesthesia and Analgesia · doi:10.1111/vaa.12200 · Cited by 25 · see citing works
Acylglycerol kinase is over-expressed in early-stage cervical squamous cell cancer and predicts poor prognosis
Sun, F., Xiong, Y., Zhou, X.-H., Li, Q., Lu, X., Long, P., Li, L.-J., Cai, M., Wei, Y., Ma, Y., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-4498-4 · Cited by 23 · see citing works
Plasma concentrations of neurotransmitters and postpartum depression.
Xie, R., Xie, H., Krewski, D. R., & He, G. (2018) · PubMed · doi:10.11817/j.issn.1672-7347.2018.03.007 · Cited by 22 · see citing works
Expression levels of resistant genes affect cervical cancer prognosis
Yang, F., Gao, B., Li, R., Li, W., Chen, W., Yu, Z., & Zhang, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6328 · Cited by 19 · see citing works
Effectiveness of an Interventional Package on the Level of Anxiety, Depression, and Fatigue among Patients with Cervical Cancer
Kaur, M., Agnihotri, M., Das, K., Rai, B., & Ghai, S. (2017) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/apjon.apjon_56_17 · Cited by 11 · see citing works
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Martin‐Jurado, O., Bektas, R. N., Fahrion, A. S., Bettschart‐Wolfensberger, R., & Hammer, S. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.9.1164 · Cited by 6 · see citing works
Sexual satisfaction, anxiety, depression and quality of life amoung Turkish gynecological cancer patients
Yıldız, Y., Akyol, M., Alacacıoğlu, A., Küçükzeybek, Y., Aşık, N., Taşkaynatan, H., Varol, U., Yıldız, İ., Oflazoğlu, U., Salman, T., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw374.38 · Cited by 5 · see citing works

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Breeksema, J. J. (2024) · doi:10.33612/diss.912040905
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Zhang, S., Wang, L., Yang, J., Feng, X., Yang, R., & Lei, X. (2024) · Thermal Science and Engineering Progress · doi:10.1016/j.tsep.2024.103145
Retracted
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黄, 芳. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14123165
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Lu, J. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1631157
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Singhal, Y., Pavan Gaurav, R., Saji, S., Pingoliya, S. K., & Ghera, D. K. (2026) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360288.2026.2679720
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Zhang, B., Wang, Z., Yu, K., Pan, Q., Guan, S., Zhang, M., Jia, R., Wang, Y., Meng, Q., Ma, Y., et al. (2026) · Perioperative Medicine · doi:10.1186/s13741-026-00711-3
Self-citation
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Akwa, G., Tiemah, N. C., Chabeja, A., Buh, F. C., & Kantaris, M. (2026) · Cureus · doi:10.7759/cureus.115806

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Liu, P., Li, P., Li, Q., Yan, H., Shi, X., Liu, C., Zhang, Y., & Peng, S. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1710626 · Cited by 103 · see citing works
Self-citation
Effect of Ketamine on perioperative depression in patients undergoing total hysterectomy
Chen, W. (2012) · Zhongguo fuyou baojian
The Efficacy of Sub‐Anesthesia S‐Ketamine on Postoperative Depressive Symptoms in Patients Undergoing Abdominal Tumor Resection: A Randomized Controlled Trial
He, Y., Yu, J., Liu, J., Cai, J., Li, Z., Xu, M., & Li, Q. (2025) · Psycho-Oncology · doi:10.1002/pon.70265 · Cited by 1 · see citing works
Untitled work
(2017) · Biomedical Research-tokyo · Cited by 15 · see citing works
Efficacy and safety of S-ketamine in pain management for breast cancer patients undergoing modified radical mastectomy: a meta-analysis of randomized controlled trials
Abu-Hussein, B., Elrosasy, A., Samy, H., Ali, A. S., Alijla, S. S., Bitar, A. N., & Gamal, I. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03847-8 · Cited by 2 · see citing works

Authors: Wang, J., Wang, Y., Xu, X., Peng, S., Xu, F., & Liu, P.
Affiliations: Department of Anesthesiology, Ninth People’s Hospital of Suzhou, Suzhou, Jiangsu, China (mainland)
Wuxi People's Hospital (CN)
Department of Anesthesiology, Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China (mainland)
Shanghai University of Traditional Chinese Medicine (CN)
Second Military Medical University (CN)
Corresponding author: Liu, Peirong
ORCID: Wang, Jie
Xu, Xudong
Peng, Sheng
Xu, Feng
Liu, Peirong
Venue: Medical Science Monitor
Publisher: International Scientific Information, Inc.
Published: 2020-04-27
Volume: 26
Pages: e922028-e922028
ISSN: 1234-1010 (ISSN-L)
1643-3750
DOI: 10.12659/msm.922028
PMC: PMC7331479
OpenAlex: W3019657248
Cited by: 81
References: 28
Citations by year: 2026: 8 · 2025: 15 · 2024: 26 · 2023: 19 · 2022: 8 · 2021: 5
FWCI: 4.79
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
Locations: Medical Science Monitor (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords: esketamine, ketamine, depression, postoperative pain, cervical cancer, racemic ketamine, brain-derived neurotrophic factor, serotonin, dose comparison, postoperative depression
MeSH terms: Adult, Antidepressive Agents, Carcinoma, Uterine Cervical Neoplasms, Depression, Depressive Disorder, Double-Blind Method, Female, Humans, Hysterectomy, Ketamine, Middle Aged, Pain Measurement, Pain, Postoperative, Postoperative Pain, Serotonin, Brain-Derived Neurotrophic Factor

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Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy

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