Cited by 98Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

IMMUNOFLUORESCENT STUDIES ON THE LOCALIZATION OF TYROSINE HYDROXYLASE AND DOPAMINE-β-HYDROXYLASE IN THE MES-, DI-, AND TELENCEPHALON OF THE RAT USING UNPERFUSED FRESH FROZEN SECTIONS

Open access
NAGATSU, IKUKO, INAGAKI, SHINOBU, KONDO, YUKARI, KARASAWA, NOBUYUKI, NAGATSU, TOSHIHARU·1979·ACTA HISTOCHEMICA ET CYTOCHEMICA

Abstract

Distributions of tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH) in the rat brain were examined using immunofluorescent staining on unperfused fresh frozen sections. TH-positive and DBH-negative dopaminergic neurons were observed in the anterior hypothalamic nucleus. In other hypothalamic nuclei such as ventromedialis, dorsomedialis, and posterior hypothalamic nuclei, a few dopaminergic neurons were also observed.Our immunofluorescent results with unperfused fresh frozen sections indicated that TH or DBH was mainly localized in the cell bodies of catecholaminergic neurons and that small amounts of the enzymes were distributed in the nerve terminals. Although it had been reported that the amine enzymes existed in nerve terminals as well as in the cell bodies by using paraformaldehyde perfused sections, the fluorescence observed in nerve terminals might be produced not only by the amine enzymes but also by amines themselves.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1267/ahc.12.20

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • DRN TH+ neurons lack dopamine-β-hydroxylase and do not express 5-HT.

    “Furthermore, DRN TH+ neurons lack dopamine-β-hydroxylase, which is necessary to convert DA to norepinephrine (Nagatsu et al., 1979), and do not express 5-hydroxytryptamine (5-HT) (Stratford and Wirtshafter, 1990).”

    From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Nagatsu et al., 1979

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
NAGATSU, I., INAGAKI, S., KONDO, Y., KARASAWA, N., & NAGATSU, T.
Affiliations
  • Department of Anatomy, School of Medicine, Fujita-Gakuen University
  • Tokyo Institute of Technology (JP)
Venue
ACTA HISTOCHEMICA ET CYTOCHEMICA
Published
1979
Volume
12
Issue
1
Pages
20-37
ISSN
  • 0044-5991 (ISSN-L)
  • 1347-5800
OpenAlex
W2018476398
Cited by
98
References
26
Citations by year
2025: 2 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2012: 2
FWCI
1.59
Type
journal article
Language
en
Open access
Locations
ACTA HISTOCHEMICA ET CYTOCHEMICA (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
tyrosine hydroxylase, dopamine beta-hydroxylase, dopaminergic neurons, catecholaminergic neurons, hypothalamus, midbrain, diencephalon, telencephalon, enzyme localization, presynaptic terminals, rat brain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review