The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
EGF receptor ligands: recent advances
Open accessAbstract
Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN). Of these, EGF, TGFA, HBEGF, and BTC are thought to be high-affinity ligands, whereas AREG, EREG, and EPGN constitute low-affinity ligands. This focused review is meant to highlight recent studies related to actions of the individual EGFR ligands, the interesting biology that has been uncovered, and relevant advances related to ligand interactions with the EGFR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2747 · Cited by 173
RetractedProduction and auto-induction of transforming growth factor-α in human keratinocytes
Coffey, R. J., Derynck, R., Wilcox, J. N., Bringman, T. S., Goustin, A. S., Moses, H. L., & Pittelkow, M. R. (1987) · Nature · doi:10.1038/328817a0 · Cited by 857
Self-citationHarris, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00105-2 · Cited by 776
Cohen, S. (1960) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.46.3.302 · Cited by 697
Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015) · Nature · doi:10.1038/nature15382 · Cited by 648
Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair
Zaiss, D. M. W., Gause, W. C., Osborne, L. C., & Artis, D. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.020 · Cited by 638
Knebel, A., Rahmsdorf, H. J., Ullrich, A., & Herrlich, P. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00916.x · Cited by 514
Ju, W., Nair, V., Smith, S., Zhu, L., Shedden, K., Song, P. X. K., Mariani, L. H., Eichinger, F. H., Berthier, C. C., Randolph, A., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7071 · Cited by 426
Amphiregulin exosomes increase cancer cell invasion
Higginbotham, J. N., Demory Beckler, M., Gephart, J. D., Franklin, J. L., Bogatcheva, G., Kremers, G.-J., Piston, D. W., Ayers, G. D., McConnell, R. E., Tyska, M. J., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.043 · Cited by 360
Self-citationBerasain, C., & Avila, M. A. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.01.005 · Cited by 304
Cited by
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Wee, P., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050052 · Cited by 2,027
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Targeting EGFR in Lung Cancer: Current Standards and Developments
Díaz-Serrano, A., Gella, P., Jiménez, E., Zugazagoitia, J., & Paz-Ares Rodríguez, L. (2018) · Drugs · doi:10.1007/s40265-018-0916-4 · Cited by 108
HER3 Alterations in Cancer and Potential Clinical Implications
Kilroy, M. K., Park, S., Feroz, W., Patel, H., Mishra, R., Alanazi, S., & Garrett, J. T. (2022) · Cancers · doi:10.3390/cancers14246174 · Cited by 21
Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis
Chen, J. Q. A., McNamara, N. B., Engelenburg, H. J., Jongejan, A., Wever, D. D., Hopman, K., van Rixel, E., Nijhuis, P. J. H., de Winter, F., Moerland, P. D., et al. (2025) · Brain · doi:10.1093/brain/awae414 · Cited by 17
Metadata
- Authors
- Singh, B., Carpenter, G., & Coffey, R. J.
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2016-09-08
- Volume
- 5
- Pages
- 2270
- ISSN
- 2046-1402 (ISSN-L)
- OpenAlex
- W2511292374
- Cited by
- 323
- References
- 85
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: EGF receptor ligands: recent advances. https://app.cochat.ai/papers/10.12688/f1000research.9025.1
- The paper
- Singh, B., Carpenter, G., & Coffey, R. J. (2016). EGF receptor ligands: recent advances. F1000Research. https://doi.org/10.12688/f1000research.9025.1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
