Cited by 174Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and Interactions

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Leptin signaling

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Park, Hyeong-Kyu, Ahima, Rexford S.·2014·F1000Prime Reports

DOI 10.12703/p6-73PMC PMC4166933

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Abstract

Leptin is secreted by adipose tissue and regulates energy homeostasis, glucose and lipid metabolism, immune function, and other systems. The binding of leptin to its specific receptor activates various intracellular signaling pathways, including Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)/phosphatidylinositol 3 kinase (PI3K), SH2-containing protein tyrosine phosphatase 2 (SHP2)/mitogen-activated protein kinase (MAPK), and 5' adenosine monophosphate-activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC), in the central nervous system and peripheral tissues. Understanding of leptin signaling provides insights into its roles in health and disease.

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Retracted
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Authors: Park, H.-K., & Ahima, R. S.
Affiliations: Soonchunhyang University (KR)
University of Pennsylvania (US)
Corresponding author: Ahima, Rexford S.
ORCID: Ahima, Rexford S.
Venue: F1000Prime Reports
Publisher: H1 Connect
Published: 2014-09-04
Volume: 6
Pages: 73-73
ISSN: 2051-7599 (ISSN-L)
DOI: 10.12703/p6-73
PMC: PMC4166933
OpenAlex: W4252710559
Cited by: 171
References: 62
Citations by year: 2026: 6 · 2025: 18 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 23 · 2019: 13 · 2018: 5 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 1
FWCI: 1.39
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: F1000Prime Reports (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: National Institutes of Health (DK049210, DK 19525)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK049210, P30DK019525)
National Institute of Neurological Disorders and Stroke (R01NS084965)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: leptin, leptin signaling, leptin receptor, energy homeostasis, glucose metabolism, lipid metabolism, immune function, JAK2/STAT3 signaling, adipose tissue, central nervous system

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