Cited by 585Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

Key enzyme in leptin-induced anorexia

Niswender, Kevin D., Morton, Gregory J., Stearns, Walter H., Rhodes, Christopher J., Myers, Martin G., Schwartz, Michael W.·2001·Nature

Integrity signals

Registry

Crossref · 10.1038/35101657

Cites

12 of 12 references verified0 citation errors · 0 not checkable

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  • Like insulin, leptin activates the IRS-PI3K pathway in the hypothalamus, and pharmacological inhibition of PI3K in the brain blocks leptin's ability to reduce food intake.

    “like insulin, leptin activates the IRS-PI3K pathway in the hypothalamus, and pharmacological inhibition of PI3K activity in the brain blocks the ability of leptin to reduce food intake (129, 130).”

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Authors
Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W.
Affiliations
  • University of Washington (US)
  • Joslin Diabetes Center (US)
Corresponding author
Schwartz, Michael W.
Venue
Nature
Published
2001-10
Volume
413
Issue
6858
Pages
794-795
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1653273172
Cited by
585
References
12
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 6 · 2019: 17 · 2018: 14 · 2017: 17 · 2016: 22 · 2015: 23 · 2014: 26 · 2013: 28 · 2012: 33
FWCI
9.38
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
leptin, anorexia, phosphatidylinositol 3-kinase, hypothalamus, food intake regulation, energy balance, signal transduction, intracerebroventricular infusion, leptin receptor
MeSH terms
Phosphoinositide-3 Kinase Inhibitors, alpha-MSH, Animals, Anorexia, Chromones, DNA-Binding Proteins, Eating, Enzyme Activation, Enzyme Inhibitors, Hypothalamus, Insulin, Morpholines, Obesity, Signal Transduction, Trans-Activators, Phosphatidylinositol 3-Kinases, Leptin, STAT3 Transcription Factor, Rats

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