Key enzyme in leptin-induced anorexia
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Like insulin, leptin activates the IRS-PI3K pathway in the hypothalamus, and pharmacological inhibition of PI3K in the brain blocks leptin's ability to reduce food intake.
“like insulin, leptin activates the IRS-PI3K pathway in the hypothalamus, and pharmacological inhibition of PI3K activity in the brain blocks the ability of leptin to reduce food intake (129, 130).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [130]
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“Thus, while it has been established that anorexia induced by intracerebroventricular leptin can be blocked by inhibiting PI3K signaling using a pharmacological approach (130), the contribution of the PI3K signaling pathway in specific hypothalamic neurons to leptin regulation of energy balance and glucose metabolism h…”
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- Authors
- Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Schwartz, Michael W.
- Venue
- Nature
- Published
- 2001-10
- Volume
- 413
- Issue
- 6858
- Pages
- 794-795
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1653273172
- Cited by
- 585
- References
- 12
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 6 · 2019: 17 · 2018: 14 · 2017: 17 · 2016: 22 · 2015: 23 · 2014: 26 · 2013: 28 · 2012: 33
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, anorexia, phosphatidylinositol 3-kinase, hypothalamus, food intake regulation, energy balance, signal transduction, intracerebroventricular infusion, leptin receptor
- MeSH terms
- Phosphoinositide-3 Kinase Inhibitors, alpha-MSH, Animals, Anorexia, Chromones, DNA-Binding Proteins, Eating, Enzyme Activation, Enzyme Inhibitors, Hypothalamus, Insulin, Morpholines, Obesity, Signal Transduction, Trans-Activators, Phosphatidylinositol 3-Kinases, Leptin, STAT3 Transcription Factor, Rats
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