Cited by 1,278Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesPI3K/AKT/mTOR signaling in cancer

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, Daniela, Proulx, Karine, Smith, Kathi A. Blake, Kozma, Sara C., Thomas, George, Woods, Stephen C., Seeley, Randy J.·2006·Science

Abstract

The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus. Central administration of leucine increases hypothalamic mTOR signaling and decreases food intake and body weight. The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect. Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake.

Integrity signals

Registry

Crossref · 10.1126/science.1124147

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Leptin has been reported to activate AMPK and mTOR signaling pathways.

    “Leptin has also been reported to activate nutrient-sensing enzymes including AMP-activated protein kinase (AMPK) (115) and mammalian target of rapamycin (mTOR) signaling pathways (41)”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J.
Affiliations
University of Cincinnati (US)
Corresponding author
Seeley, Randy J.
Venue
Science
Published
2006-05-12
Volume
312
Issue
5775
Pages
927-930
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2067152194
Cited by
1,278
References
27
Citations by year
2026: 26 · 2025: 33 · 2024: 43 · 2023: 46 · 2022: 43 · 2021: 50 · 2020: 50 · 2019: 61 · 2018: 60 · 2017: 62 · 2016: 68 · 2015: 72 · 2014: 83 · 2013: 84 · 2012: 108
FWCI
28.98
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK17844, DK54080, R01DK054080, R01DK054890, DK-54890)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
mTOR signaling, hypothalamus, dietary intake, energy balance, arcuate nucleus, neuropeptide Y, proopiomelanocortin, leptin, leucine, nutrient sensing, anorectic effect, body weight regulation
MeSH terms
Animals, Arcuate Nucleus of Hypothalamus, Energy Intake, Eating, Energy Metabolism, Fasting, Hypothalamus, Injections, Intraventricular, Leucine, Neurons, Neuropeptide Y, Phosphorylation, Protein Kinases, Valine, Signal Transduction, Weight Loss, Ribosomal Protein S6 Kinases, Sirolimus, Rats, Long-Evans, Leptin, Ribosomal Protein S6, STAT3 Transcription Factor, Rats, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review