MyD88: a central player in innate immune signaling

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286

CpG Motifs in Bacterial DNA and Their Immune Effects

Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783

Oncogenically active MYD88 mutations in human lymphoma

Ngo, V. N., Young, R. M., Schmitz, R., Jhavar, S. G., Xiao, W., Lim, K., Kohlhammer, H., Xu, W., Yang, Y., Zhao, H., et al. (2010) · Nature · doi:10.1038/nature09671 · Cited by 1,560

Toll-like Receptor Signaling

Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,499

Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S., Lee, H., & Lee, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.008 · Cited by 1,388

Toll-like receptors control activation of adaptive immune responses

Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,310

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

von Bernuth, H., Pïcard, C., Jin, Z., Sranujit, R. P., Xiao, H. Q., Ku, C., Chrabieh, M., Ben‐Mustapha, I., Ghandil, P., Çamcıoğlu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, K. A., Pålsson‐McDermott, E. M., Bowie, A., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E. K., Dunne, A., Gray, P., Harte, M. T., et al. (2001) · Nature · doi:10.1038/35092578 · Cited by 1,258

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

Wesche, H., Henzel, W., Shillinglaw, W., Li, S., & Cao, Z.-D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,247

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,217

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

Muzio, M., Ni, J., Feng, P., & Dixit, V. M. (1997) · Science · doi:10.1126/science.278.5343.1612 · Cited by 1,170

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

Takeuchi, O., Hoshino, K., & Akira, S. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.10.5392 · Cited by 1,156

Helical Assembly in the MyD88-IRAK4-IRAK2 Complex in TLR/IL-1R Signalling

Lin, S.-C., Lo, Y.-C., & Wu, H. (2010) · Nature · doi:10.1038/nature09121 · Cited by 1,111

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., et al. (2002) · Nature · doi:10.1038/nature01182 · Cited by 1,009

TIRAP: an adapter molecule in the Toll signaling pathway

Horng, T., Barton, G. M., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni0901-835 · Cited by 970

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

Kagan, J. C., & Medzhitov, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.047 · Cited by 868

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

Means, T. K., Latz, E., Hayashi, F., Murali, M. R., Golenbock, D. T., & Luster, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23025 · Cited by 866

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T., Barton, G. M., Flavell, R. A., & Medzhitov, R. M. (2002) · Nature · doi:10.1038/nature01180 · Cited by 825

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R. M., Manley, J. L., & Tong, L. (2000) · Nature · doi:10.1038/35040600 · Cited by 815

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M., & Davies, D. R. (2008) · Science · doi:10.1126/science.1155406 · Cited by 733

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

Burns, K., Martinon, F., Esslinger, C., Pahl, H. L., Schneider, P., Bodmer, J.-L., Marco, F. D., French, L. E., & Tschopp, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12203 · Cited by 631

Drosophila Toll and IL-1 receptor

Gay, N. J., & Keith, F. J. (1991) · Nature · doi:10.1038/351355b0 · Cited by 623

Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain

Choe, J., Kelker, M. S., & Wilson, I. A. (2005) · Science · doi:10.1126/science.1115253 · Cited by 620

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., et al. (2006) · Nature Immunology · doi:10.1038/ni1297 · Cited by 600

The smallest known non-avian theropod dinosaur

Xu, X., Zhou, Z., & Wang, X. (2000) · Nature · doi:10.1038/35047056 · Cited by 539

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Yeh, W., & Taniguchi, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406933101 · Cited by 526

Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., & Tschopp, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021790 · Cited by 512

Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells

Scanga, C. A., Aliberti, J., Jankovic, D. L., Tilloy, F., Bennouna, S., Denkers, E., Medzhitov, R. M., & Sher, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.5997 · Cited by 500

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

Barbalat, R., Lau, L., Locksley, R. M., & Barton, G. M. (2009) · Nature Immunology · doi:10.1038/ni.1792 · Cited by 477

Expanding TRAF function: TRAF3 as a tri-faced immune regulator

Häcker, H., Tseng, P.-H., & Karin, M. (2011) · Nature Reviews Immunology · doi:10.1038/nri2998 · Cited by 471

Ligand-induced conformational changes allosterically activate Toll-like receptor 9

Latz, E., Verma, A., Visintin, A., Gong, M., Sirois, C. M., Klein, D. C. G., Monks, B. G., McKnight, C. J., Lamphier, M. S., Duprex, W. P., et al. (2007) · Nature Immunology · doi:10.1038/ni1479 · Cited by 462

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency

Pïcard, C., Casanova, J., & Puel, A. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-11 · Cited by 408

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

Motshwene, P. G., Moncrieffe, M. C., Grossmann, J. G., Kao, C. C., Murali, A., Sandercock, A. M., Robinson, C. V., Latz, E., & Gay, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022392 · Cited by 403

The molecular structure of the Toll-like receptor 3 ligand-binding domain

Bell, J. K., Botos, I., Hall, P. R., Askins, J., Shiloach, J., Segal, D. M., & Davies, D. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505077102 · Cited by 387

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Tanji, H., Ohto, U., Shibata, T., Miyake, K., & Shimizu, T. (2013) · Science · doi:10.1126/science.1229159 · Cited by 369

A comprehensive map of the toll‐like receptor signaling network

Oda, K., & Kitano, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100057 · Cited by 362

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

Sasai, M., Linehan, M. M., & Iwasaki, A. (2010) · Science · doi:10.1126/science.1187029 · Cited by 357

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

He, B., Santamaría, R., Xu, W., Cols, M., Chen, K., Puga, I., Shan, M., Xiong, H., Bussel, J. B., Chiu, A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1914 · Cited by 349

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.014 · Cited by 348

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

Schneider, D. S., Hudson, K. L., Lin, T. Y., & Anderson, K. V. (1991) · Genes & Development · doi:10.1101/gad.5.5.797 · Cited by 325

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

Swann, J. B., Vesely, M. D., Silva, A., Sharkey, J., Akira, S., Schreiber, R. D., & Smyth, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708594105 · Cited by 320

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1920 · Cited by 283

UNC93B1 mediates differential trafficking of endosomal TLRs

Lee, B. L., Moon, J. E., Shu, J. H., Yuan, L., Newman, Z. R., Schekman, R., & Barton, G. M. (2013) · eLife · doi:10.7554/elife.00291 · Cited by 281

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., & Wu, H. (2007) · Cell · doi:10.1016/j.cell.2007.01.019 · Cited by 280

Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

Lord, K. A., Hoffman‐Liebermann, B., & Liebermann, D. A. (1990) · PubMed · Cited by 263

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

Bonham, K. S., Orzalli, M. H., Hayashi, K., Wolf, A. I., Glanemann, C., Weninger, W., Iwasaki, A., Knipe, D. M., & Kagan, J. C. (2014) · Cell · doi:10.1016/j.cell.2014.01.019 · Cited by 232

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

Ohnishi, H., Tochio, H., Kato, Z., Orii, K. E., Li, A., Kimura, T., Hiroaki, H., Kondo, N., & Shirakawa, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812956106 · Cited by 219

Trafficking of endosomal Toll-like receptors

Lee, B. L., & Barton, G. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.002 · Cited by 214

MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA

Sun, D., & Ding, A. H. (2006) · Nature Immunology · doi:10.1038/ni1308 · Cited by 210

High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

Kraan, W., Horlings, H. M., van Keimpema, M., Schilder-Tol, E. J. M., Oud, M. E. C. M., Scheepstra, C. G., Kluin, P. M., Kersten, M. J., Spaargaren, M., & Pals, S. T. (2013) · Blood Cancer Journal · doi:10.1038/bcj.2013.28 · Cited by 205

MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression

Janssens, S., Burns, K., Vercammen, E., Tschopp, J., & Beyaert, R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00747-6 · Cited by 197

Macrophage Differentiation Marker MyD88 Is a Member of the Toll/IL-1 Receptor Family

Hultmark, D. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1206 · Cited by 138

Crystal Structure of the Toll/Interleukin-1 Receptor Domain of Human IL-1RAPL

Khan, J., Brint, E. K., O'Neill, L. A. J., & Tong, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403434200 · Cited by 132

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

Kenny, E. F., Talbot, S., Gong, M., Golenbock, D. T., Bryant, C. E., & O'Neill, L. A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901140 · Cited by 110

Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

Dimicoli, S., Wei, Y., Bueso-Ramos, C., Yang, H., Dinardo, C. D., Jia, Y., Zheng, H., Fang, Z., Nguyen, M. H., Pierce, S. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071120 · Cited by 72

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly

George, J., Motshwene, P. G., Wang, H., Kubarenko, A. V., Rautanen, A., Mills, T. C., Hill, A. V. S., Gay, N. J., & Weber, A. N. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159996 · Cited by 66

Pyogenic Bacterial Infections in Humans With MyD88 Deficiency

Gern, J. E. (2009) · PEDIATRICS · doi:10.1542/peds.2009-1870yyy · Cited by 45

Toll-like Receptor-Deficient Mice Reveal How Innate Immune Signaling Influences Salmonella Virulence Strategies

Sivick, K. E., Arpaia, N., Reiner, G. L., Lee, B. L., Russell, B. R., & Barton, G. M. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.01.013 · Cited by 40

Cutting Edge: A TLR9 Cytoplasmic Tyrosine Motif Is Selectively Required for Proinflammatory Cytokine Production

Chockalingam, A., Rose, W., Hasan, M., Ju, C., & Leifer, C. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102713 · Cited by 27

Pillars Article: MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity. 1997. 7: 837–847

Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., & Cao, Z. (2013) · The Journal of Immunology · doi:10.1093/jimmunol/190.1.5 · Cited by 13

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Scheithauer, T. P. M., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., van Raalte, D. H., & Herrema, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571731 · Cited by 715

Cross Talk Pathways Between Coagulation and Inflammation

Foley, J. H., & Conway, E. M. (2016) · Circulation Research · doi:10.1161/circresaha.116.306853 · Cited by 595

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 524

The emerging mechanisms and functions of microautophagy

Wang, L., Klionsky, D. J., & Shen, H. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00529-z · Cited by 495

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

Sundaram, B., Nagakannan, P., Mall, R., Wang, Y., Sarkar, R., Kim, H. J., Malireddi, R. K. S., Karki, R., Janke, L. J., Vogel, P., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.005 · Cited by 443

A universal role for MyD88 in TLR/IL-1R-mediated signaling

Janssens, S., & Beyaert, R. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02145-x · Cited by 417

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

Wesche, H., Henzel, W., Shillinglaw, W., Li, S., & Cao, Z.-D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,247

Activation mechanisms of the innate immune system: structure-function studies of interactions between death domains of MyD88 and IRAK proteins

Barberá, M., & de, E. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

Burns, K., Martinon, F., Esslinger, C., Pahl, H. L., Schneider, P., Bodmer, J.-L., Marco, F. D., French, L. E., & Tschopp, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12203 · Cited by 631

MyD88 as a Bottle Neck in Toll/IL-1 Signaling

Takeuchi, O., & Akira, S. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59430-4_10 · Cited by 140