Expanding TRAF function: TRAF3 as a tri-faced immune regulator

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works

The two NF-κB activation pathways and their role in innate and adaptive immunity

Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535 · see citing works

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature · doi:10.1038/35085597 · Cited by 2,125 · see citing works

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00126-4 · Cited by 1,872 · see citing works

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., & Varshavsky, A. (1989) · Science · doi:10.1126/science.2538923 · Cited by 1,535 · see citing works

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361 · see citing works

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00053-4 · Cited by 1,342 · see citing works

TRAF6 is a signal transducer for interleukin-1

Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., & Goeddel, D. V. (1996) · Nature · doi:10.1038/383443a0 · Cited by 1,305 · see citing works

Regulation and Function of IKK and IKK-Related Kinases

Häcker, H., & Karin, M. (2006) · Science s STKE · doi:10.1126/stke.3572006re13 · Cited by 1,269 · see citing works

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,256 · see citing works

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

Rothe, M., Pan, M., Henzel, W. J., Ayres, T. M., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90149-3 · Cited by 1,249 · see citing works

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

Wesche, H., Henzel, W., Shillinglaw, W., Li, S., & Cao, Z.-D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,247 · see citing works

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.030 · Cited by 1,218 · cited 1× · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Zhang, S., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P. J., Segal, D. M., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., et al. (2007) · Science · doi:10.1126/science.1139522 · Cited by 1,165 · see citing works

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102 · see citing works

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

Vince, J. E., Wong, W. W.-L., Khan, N. R., Feltham, R., Chau, D., Ahmed, A. U., Benetatos, C. A., Chunduru, S. K., Condon, S. M., McKinlay, M. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.037 · Cited by 1,061 · see citing works

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054 · see citing works

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

Rothe, M., Sarma, V. J., Dixit, V. M., & Goeddel, D. V. (1995) · Science · doi:10.1126/science.7544915 · Cited by 1,050 · see citing works

Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7

Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,038 · see citing works

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Kawai, T., & Akira, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.020 · Cited by 985 · see citing works

Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

Keats, J. J., Fonseca, R., Chesi, M., Schop, R., Baker, A., Chng, W.-J., Van Wier, S., Tiedemann, R., Shi, C.-X., Sebag, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.003 · Cited by 983 · see citing works

Essential function for the kinase TAK1 in innate and adaptive immune responses

Sato, S., Sanjo, H., Takeda, K., Ninomiya‐Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1255 · Cited by 974 · see citing works

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962 · see citing works

Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma

Annunziata, C. M., Davis, R. E., Demchenko, Y., Bellamy, W., Gabrea, A., Zhan, F., Lenz, G., Hanamura, I., Wright, G., Xiao, W., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.07.004 · Cited by 952 · see citing works

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

Tokunaga, F., Sakata, S., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1821 · Cited by 943 · see citing works

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B. J., Perry, A. K., & Cheng, G. (2005) · Nature · doi:10.1038/nature04374 · Cited by 881 · see citing works

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

Xiao, G., Harhaj, E. W., & Sun, S. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00187-3 · Cited by 836 · see citing works

A ubiquitin ligase complex assembles linear polyubiquitin chains

Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, M., Sano, S., Tokunaga, F., Tanaka, K., & Iwaï, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601360 · Cited by 772 · see citing works

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

Haas, T. L., Emmerich, C. H., Gerlach, B., Schmukle, A. C., Cordier, S. M., Rieser, E., Feltham, R., Vince, J. E., Warnken, U. H., Wenger, T., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.013 · Cited by 768 · see citing works

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J. C., Strub, G. M., Kim, E. Y., Maceyka, M. W., Jiang, H., Luo, C., Kordula, T., et al. (2010) · Nature · doi:10.1038/nature09128 · Cited by 754 · see citing works

A cell biological view of Toll-like receptor function: regulation through compartmentalization

Barton, G. M., & Kagan, J. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2587 · Cited by 713 · see citing works

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

Claudio, E., Brown, K., Park, S., Wang, H., & Siebenlist, U. K. (2002) · Nature Immunology · doi:10.1038/ni842 · Cited by 694 · see citing works

CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturation

Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R. M., Sparwasser, T. D., Heeg, K. M., Lipford, G. B., & Wagner, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6230 · Cited by 654 · see citing works

Ubiquitylation in innate and adaptive immunity

Bhoj, V. G., & Chen, Z. J. (2009) · Nature · doi:10.1038/nature07959 · Cited by 639 · see citing works

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

Vallabhapurapu, S., Matsuzawa, A., Zhang, W., Tseng, P., Keats, J. J., Wang, H., Vignali, D. A. A., Bergsagel, P. L., & Karin, M. (2008) · Nature Immunology · doi:10.1038/ni.1678 · Cited by 605 · see citing works

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

Yamashita, M., Fátyol, K., Jin, C., Wang, X., Liu, Z.-G., & Zhang, Y. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.002 · Cited by 559 · see citing works

Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation

Liao, G., Zhang, M., Harhaj, E. W., & Sun, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403286200 · Cited by 467 · see citing works

Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6

Häcker, H., Vabulas, R. M., Takeuchi, O., Hoshino, K., Akira, S., & Wagner, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.595 · Cited by 466 · see citing works

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainPreprint

Baud, V., Liu, Z.-G., Bennett, B. L., Suzuki, N., Xia, Y., & Karin, M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1297 · Cited by 464 · see citing works

A Deubiquitinase That Regulates Type I Interferon Production

Kayagaki, N., Phung, Q. T., Chan, S. B., Chaudhari, R., Quan, C., O’Rourke, K. M., Eby, M. T., Pietras, E. M., Cheng, G., Bazán, J. F., et al. (2007) · Science · doi:10.1126/science.1145918 · Cited by 452 · see citing works

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

Cheng, G., Cohen, A. C., Ye, Z.-S., Hong, D., Lederman, S. M., & Baltimore, D. (1995) · Science · doi:10.1126/science.7533327 · Cited by 449 · see citing works

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Saha, S. K., Pietras, E. M., He, J. Q., Kang, J. R., Liu, S.-Y., Oganesyan, G., Shahangian, A., Zarnegar, B. J., Shiba, T. L., Wang, Y., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601220 · Cited by 423 · see citing works

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

Gao, M., Labuda, T., Xia, Y., Gallagher, E. D., Fang, D., Liu, Y., & Karin, M. (2004) · Science · doi:10.1126/science.1099414 · Cited by 397 · see citing works

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Tseng, P., Matsuzawa, A., Zhang, W., Mino, T., Vignali, D. A. A., & Karin, M. (2009) · Nature Immunology · doi:10.1038/ni.1819 · Cited by 388 · see citing works

Inhibition of Proteolysis and Cell Cycle Progression in a Multiubiquitination-Deficient Yeast Mutant

Finley, D. J., Sadis, S., Monia, B. P., Boucher, P., Ecker, D. J., Crooke, S. T., & Chau, V. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5501 · Cited by 374 · see citing works

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

de Diego, R. P., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., Plancoulaine, S., Pïcard, C., Casadio, M., Cardon, A., Durandy, A., Bustamante, J. C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.014 · Cited by 348 · see citing works

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Hu, H., O’Rourke, K. M., Boguski, M. S., & Dixit, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43772-6 · Cited by 341 · see citing works

Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling

Gohda, J., Matsumura, T., & Inoue, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.2913 · Cited by 312 · see citing works

Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation

Xiao, G., Fong, A., & Sun, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401428200 · Cited by 296 · see citing works

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

Ermolaeva, M., Michallet, M., Papadopoulou, N., Utermöhlen, O., Kranidioti, K., Kollias, G. A., Tschopp, J., & Pasparakis, M. (2008) · Nature Immunology · doi:10.1038/ni.1638 · Cited by 277 · see citing works

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Yamamoto, M., Okamoto, T., Takeda, K., Sato, S., Sanjo, H., Uematsu, S., Saitoh, T., Yamamoto, N., Sakurai, H., Ishii, K. J., et al. (2006) · Nature Immunology · doi:10.1038/ni1367 · Cited by 265 · see citing works

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

Gardam, S., Sierro, F., Basten, A., Mackay, F., & Brink, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.01.009 · Cited by 248 · see citing works

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

Xu, M., Skaug, B. A., Zeng, W., & Chen, Z. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.002 · Cited by 246 · see citing works

Mekk3 is essential for early embryonic cardiovascular development

Yang, J., Boerm, M., McCarty, M. F., BUCANA, C. D., Fidler, I. J., Yang, Y. Z. J., & Su, B. (2000) · Nature Genetics · doi:10.1038/73550 · Cited by 244 · see citing works

TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

Hauer, J., Püschner, S., Ramakrishnan, P., Simon, U., Bongers, M., Federle, C., & Engelmann, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500187102 · Cited by 242 · see citing works

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

Vince, J. E., Pantaki-Eimany, D., Feltham, R., Mace, P. D., Cordier, S. M., Schmukle, A. C., Davidson, A. J., Callus, B. A., Wong, W. W.-L., Gentle, I. E., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.072256 · Cited by 241 · see citing works

Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Critical Regulator of B Cell Homeostasis in Secondary Lymphoid Organs

Xie, P., Stunz, L. L., Larison, K. D., Yang, B., & Bishop, G. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.012 · Cited by 217 · see citing works

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

Matsuzawa, A., Tseng, P., Vallabhapurapu, S., Luo, J., Zhang, W., Wang, H., Vignali, D. A. A., Gallagher, E. D., & Karin, M. (2008) · Science · doi:10.1126/science.1157340 · Cited by 217 · see citing works

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

Zheng, C., Kabaleeswaran, V., Wang, Y., Cheng, G., & Wu, H. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.009 · Cited by 206 · see citing works

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

Nakano, H., Komazawa‐Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9803 · Cited by 189 · see citing works

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

Zeng, W., Xu, M., Liu, S., Sun, L., & Chen, Z. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.037 · Cited by 187 · see citing works

Control of canonical NF-κB activation through the NIK–IKK complex pathway

Zarnegar, B. J., Yamazaki, S., He, J. Q., & Cheng, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707959105 · Cited by 183 · see citing works

RIPK1 is not essential for TNFR1-induced activation of NF-κB

Wong, W. W.-L., Gentle, I. E., Nachbur, U., Anderton, H., Vaux, D. L., & Silke, J. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.178 · Cited by 183 · see citing works

TNFR signaling: ubiquitin‐conjugated TRAFfic signals control stop‐and‐go for MAPK signaling complexes

Karin, M., & Gallagher, E. D. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00755.x · Cited by 178 · see citing works

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Nakhaei, P., Mésplède, T., Solis, M., Sun, Q., Zhao, T., Yang, L., Chuang, T., Ware, C. F., Lin, R., & Hiscott, J. B. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000650 · Cited by 173 · see citing works

Rescue of TRAF3-null mice by p100 NF-κB deficiency

He, J. Q., Zarnegar, B. J., Oganesyan, G., Saha, S. K., Yamazaki, S., Doyle, S. E., Dempsey, P. W., & Cheng, G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061166 · Cited by 166 · see citing works

TRAF ‐Mediated TNFR ‐Family Signaling

Arron, J. R., Walsh, M. C., & Choi, Y. (2002) · Current Protocols in Immunology · doi:10.1002/0471142735.im1109ds51 · Cited by 157 · see citing works

TRAF‐Mediated TNFR‐Family Signaling

Ha, H., Han, D., & Choi, Y. (2009) · Current Protocols in Immunology · doi:10.1002/0471142735.im1109ds87 · Cited by 155 · see citing works

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

Paz, S., Vilasco, M., Werden, S. J., Arguello, M., Joseph-Pillai, D., Zhao, T., Nguyên, T. L.-A., Sun, Q., MEURS, E. F., Lin, R., et al. (2011) · Cell Research · doi:10.1038/cr.2011.2 · Cited by 148 · see citing works

MAVS Self-Association Mediates Antiviral Innate Immune Signaling

Tang, E., & Wang, C. (2009) · Journal of Virology · doi:10.1128/jvi.02623-08 · Cited by 141 · see citing works

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

Zhu, S., Pan, W. Q., Shi, P., Gao, H., Zhao, F., Song, X., Liu, Y., Zhao, L., Li, X., Shi, Y., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100703 · Cited by 138 · see citing works

Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling

Yamazaki, K., Gohda, J., Kanayama, A., Miyamoto, Y., Sakurai, H., Yamamoto, M., Akira, S., Hayashi, H., Su, B., & Inoue, J. (2009) · Science Signaling · doi:10.1126/scisignal.2000387 · Cited by 130 · see citing works

Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling

Xie, P., Hostager, B. S., Munroe, M. E., Moore, C. R., & Bishop, G. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5388 · Cited by 116 · see citing works

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors

Chen, N., Chio, I. I. C., Lin, W., Duncan, G. S., Chau, H., Katz, D., Huang, H.-L., Pike, K. A., Hao, Z., Su, Y.-W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806585105 · Cited by 116 · see citing works

T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification

Langenkamp, A., Casorati, G., Garavaglia, C., Dellabona, P., Lanzavecchia, A., & Sallusto, F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200207)32:7 · Cited by 113 · see citing works

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

Yin, Q., Lamothe, B., Darnay, B. G., & Wu, H. (2009) · Biochemistry · doi:10.1021/bi901462e · Cited by 112 · see citing works

Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase

Amir, R. E., Haecker, H., Karin, M., & Ciechanover, A. J. (2003) · Oncogene · doi:10.1038/sj.onc.1207366 · Cited by 109 · see citing works

Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

Gallagher, E. D., Enzler, T., Matsuzawa, A., Anzelon-Mills, A. N., Otero, D. C., Holzer, R. G., Janssen, E. M., Gao, M., & Karin, M. (2006) · Nature Immunology · doi:10.1038/ni1421 · Cited by 106 · see citing works

Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice

Régnier, C. H., Masson, R., Kedinger, V., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052124799 · Cited by 104 · see citing works

Specificity of TRAF3 in Its Negative Regulation of the Noncanonical NF-κB Pathway

He, J. Q., Saha, S. K., Kang, J. R., Zarnegar, B. J., & Cheng, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610271200 · Cited by 101 · see citing works

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

Xie, P., Kraus, Z., Stunz, L. L., Liu, Y., & Bishop, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000290 · Cited by 100 · see citing works

Asymmetric Recruitment of cIAPs by TRAF2

Mace, P. D., Smits, C., Vaux, D. L., Silke, J., & Day, C. L. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.04.055 · Cited by 79 · see citing works

TRAF4 Deficiency Leads to Tracheal Malformation with Resulting Alterations in Air Flow to the Lungs

Shiels, H., Li, X., Schumacker, P. T., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64578-6 · Cited by 77 · see citing works

Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

Sanjo, H., Zajonc, D. M., Braden, R. L., Norris, P. S., & Ware, C. F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105874 · Cited by 74 · see citing works

TNF受容体(TNFR)関連因子(TRAF)3はTRAF結合性TNFRによる非定型的NFκB経路のTRAF2/5介在性活性化の阻害物質として働く

Hauer, J., Püschner, S., Ramakrishnan, P., Simon, U., Bongers, M., Federle, C., & Engelmann, H. (2005) · Cited by 58 · see citing works

Tumor Necrosis Factor-Receptor–associated Factor-4 Is a Positive Regulator of Transforming Growth Factor-β Signaling That Affects Neural Crest Formation

Kalkan, T., Iwasaki, Y., Park, C. Y., & Thomsen, G. H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0325 · Cited by 48 · see citing works

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693 · see citing works

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1

Abe, T., & Barber, G. N. (2014) · Journal of Virology · doi:10.1128/jvi.00037-14 · Cited by 767 · see citing works

MyD88: a central player in innate immune signaling

Deguine, J., & Barton, G. M. (2014) · F1000Prime Reports · doi:10.12703/p6-97 · Cited by 692 · see citing works

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Levey, D. F., Stein, M. B., Wendt, F. R., Pathak, G. A., Zhou, H., Aslan, M., Quaden, R., Harrington, K. M., Nuñez, Y. Z., Overstreet, C., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00860-2 · Cited by 422 · see citing works

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Xiao, Y., Jin, J., Chang, M., Chang, J.-H., Hu, H., Zhou, X., Brittain, G. C., Stansberg, C., Torkildsen, Ø., Wang, X., et al. (2013) · Nature Medicine · doi:10.1038/nm.3111 · Cited by 184 · see citing works

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

Molony, R. D., Nguyen, J. T., Kong, Y., Montgomery, R. R., Shaw, A. C., & Iwasaki, A. (2017) · Science Signaling · doi:10.1126/scisignal.aan2392 · Cited by 154 · see citing works

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L., & Boyce, B. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66947 · Cited by 164 · see citing works

The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor

Kraemer, B. R., Yoon, S. O., & Carter, B. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_6 · Cited by 125 · see citing works

Regulation of Inflammatory Response by 3-Methyladenine Involves the Coordinative Actions on Akt and Glycogen Synthase Kinase 3β Rather than Autophagy

Lin, Y.-C., Kuo, H.-C., Wang, J.-S., & Lin, W.-W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102739 · Cited by 46 · see citing works

Mechanism of Temperature Regulator and Application of Home Produced Regulator

Wang, Y.-Y., & Shanghai, S. (2006) · Pharmaceutical & Engineering Design

On the Replacement of Electronic Regulator in Vehicles

Shengwei, X. (2007) · Journal of Sichuan Vocational and Technical College

Characteristics of low-output flow-stabilized regulator under high working pressure

Chi-min, Z. (2011) · Journal of Rocket Propulsion · Cited by 1 · see citing works

FLOW CHARACTERISTICS MEASUREMENT OF REGULATOR BASED ON ONE FILLING-FOR-ONCE METHOD

Fan, W. (2007) · Chinese Journal of Mechanical Engineering

The vehicle uses the alternator and regulator's correct match and the use

Wen-tian, Z. (2009) · Journal of Qinghai Normal University