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Procyanidin B1 Is Detected in Human Serum after Intake of Proanthocyanidin-rich Grape Seed Extract
Abstract
To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and beta-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4beta-->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 +/- 2.5 nmol/l.
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Ariga, T., & Hamano, M. (1990) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1990.10870369 · Cited by 123
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Hollman, P. C. H., Cassidy, A., Comte, B., Heinonen, M., Richelle, M., Richling, E., Serafini, M., Scalbert, A., Sies, H., & Vidry, S. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.131490 · Cited by 406
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Metadata
- Authors
- SANO, A., YAMAKOSHI, J., TOKUTAKE, S., TOBE, K., KUBOTA, Y., & KIKUCHI, M.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 67
- Issue
- 5
- Pages
- 1140-1143
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W1991091713
- Cited by
- 227
- References
- 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- SANO, A., YAMAKOSHI, J., TOKUTAKE, S., TOBE, K., KUBOTA, Y., & KIKUCHI, M. (2003). Procyanidin B1 Is Detected in Human Serum after Intake of Proanthocyanidin-rich Grape Seed Extract. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.67.1140
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