Bioavailability of Astaxanthin in Haematococcus Algal Extract: The Effects of Timing of Diet and Smoking Habits
Abstract
Astaxanthin is a caroteonid that possesses strong antioxidant activity. Recently, many studies on biological activity have been reported. In general, the absorption of carotenoids is affected greatly by diet and by smoking. In this report, we investigated astaxanthin pharmacokinetics after administration of Haematococcus algal extract, a source of astaxanthin, to smokers and nonsmokers before and after a meal; astaxanthin was given before the meal to nonsmokers (n = 7), after the meal to nonsmokers (n = 6), and after the meal to smokers (n = 7), then serum samples were analyzed. The timing of administration greatly affected astaxanthin bioavailability including the area under the curve (AUC(0-168), 2,968 + or - 959 microg h/l in the before-meal group vs. 7,219 + or - 3,118 microg h/l in the after-meal group), indicating high availability in the after-meal group. Smoking also affected the pharmacokinetic parameters and reduced the half-life (t(1/2)) of astaxanthin elimination significantly.
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Astaxanthin increased more in serum when the dose was taken 10 min after a meal rather than 2 h before.
“Astaxanthin increased more in serum when the dose was taken 10 min after a meal rather than 2 h before, evidence of complex factors affecting its bioaccessibility.”
From Algae as nutritional and functional food sources: revisiting our understanding. (2017) · cites this paper as Okada et al. 2009
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The Red Gold of Aquaculture: The Dual Role of Astaxanthin in Aquatic Nutrition and Human Health
Moghadam, B. B., Hafezieh, M., Shafiei, S., Shirian, S., & Pirali-Kheirabadi, E. (2025) · Aquaculture Research · doi:10.1155/are/7000490 · Cited by 3 · see citing works
Nutraceutical Potential of Astaxanthin in Muscle Metabolism, Exercise Adaptation, and Obesity
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Antiviral Activity of Haematococcus pluvialis Algae Extract Is Not Exclusively Due to Astaxanthin
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Inhibitory and Inducing Effects of Astaxanthin on CYP
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- Authors
- OKADA, Y., ISHIKURA, M., & MAOKA, T.
- Affiliations
- Yamaha Motor Co., Ltd. (Japan) (JP)
- Research Institute for Production Development (JP)
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2009-09-23
- Volume
- 73
- Issue
- 9
- Pages
- 1928-1932
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2065522662
- Cited by
- 94
- References
- 17
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- astaxanthin, bioavailability, pharmacokinetics, smoking, timing of drug administration, meal timing, carotenoids, serum concentration, elimination half-life, antioxidants
- MeSH terms
- Adolescent, Adult, Biological Availability, Diet, Female, Humans, Male, Middle Aged, Plant Extracts, Smoking, Area Under Curve, Xanthophylls, Young Adult, Eukaryota
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