Cited by 94Antioxidant Activity and Oxidative StressFatty Acid Research and HealthSeaweed-derived Bioactive Compounds

Bioavailability of Astaxanthin in Haematococcus Algal Extract: The Effects of Timing of Diet and Smoking Habits

OKADA, Yumika, ISHIKURA, Masaharu, MAOKA, Takashi·2009·Bioscience, Biotechnology, and Biochemistry

Abstract

Astaxanthin is a caroteonid that possesses strong antioxidant activity. Recently, many studies on biological activity have been reported. In general, the absorption of carotenoids is affected greatly by diet and by smoking. In this report, we investigated astaxanthin pharmacokinetics after administration of Haematococcus algal extract, a source of astaxanthin, to smokers and nonsmokers before and after a meal; astaxanthin was given before the meal to nonsmokers (n = 7), after the meal to nonsmokers (n = 6), and after the meal to smokers (n = 7), then serum samples were analyzed. The timing of administration greatly affected astaxanthin bioavailability including the area under the curve (AUC(0-168), 2,968 + or - 959 microg h/l in the before-meal group vs. 7,219 + or - 3,118 microg h/l in the after-meal group), indicating high availability in the after-meal group. Smoking also affected the pharmacokinetic parameters and reduced the half-life (t(1/2)) of astaxanthin elimination significantly.

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  • Astaxanthin increased more in serum when the dose was taken 10 min after a meal rather than 2 h before.

    “Astaxanthin increased more in serum when the dose was taken 10 min after a meal rather than 2 h before, evidence of complex factors affecting its bioaccessibility.”

    From Algae as nutritional and functional food sources: revisiting our understanding. (2017) · cites this paper as Okada et al. 2009

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Authors
OKADA, Y., ISHIKURA, M., & MAOKA, T.
Affiliations
  • Yamaha Motor Co., Ltd. (Japan) (JP)
  • Research Institute for Production Development (JP)
Venue
Bioscience, Biotechnology, and Biochemistry
Published
2009-09-23
Volume
73
Issue
9
Pages
1928-1932
ISSN
  • 0916-8451 (ISSN-L)
  • 1347-6947
OpenAlex
W2065522662
Cited by
94
References
17
Citations by year
2026: 2 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 3
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Locations
  • Bioscience Biotechnology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords
astaxanthin, bioavailability, pharmacokinetics, smoking, timing of drug administration, meal timing, carotenoids, serum concentration, elimination half-life, antioxidants
MeSH terms
Adolescent, Adult, Biological Availability, Diet, Female, Humans, Male, Middle Aged, Plant Extracts, Smoking, Area Under Curve, Xanthophylls, Young Adult, Eukaryota

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