The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Endocrine disruptors and human health--is there a problem? An update.
Open accessAbstract
It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic variations in sperm counts within countries or regions, and analyses of North American data show that sperm counts have not decreased over the last 60 years. Analyses of records for hypospadias and cryptorchidism also show demographic differences in these disorders before 1985; however, since 1985 rates of hypospadias have not changed and cryptorchidism has actually declined. Temporal changes in sex ratios and fertility are minimal, whereas testicular cancer is increasing in most countries; however, in Scandinavia, the difference between high (Denmark) and low (Finland) incidence areas are not well understood and are unlikely to be correlated with differences in exposure to synthetic industrial chemicals. Results from studies on organochlorine contaminants (DDE/PCB) show that levels were not significantly different in breast cancer patients versus controls. Thus, many of the male and female reproductive tract problems linked to the endocrine-disruptor hypothesis have not increased and are not correlated with synthetic industrial contaminants. This does not exclude an endocrine-etiology for some adverse environmental effects or human problems associated with high exposures to some chemicals.
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Cites
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
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Self-citationDevelopmental effects of endocrine-disrupting chemicals in wildlife and humans.
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Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
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Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving
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Cited by
The Effects of Metals as Endocrine Disruptors
Iavicoli, I., Fontana, L., & Bergamaschi, A. (2009) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400902902062 · Cited by 486
Wagner, M., & Oehlmann, J. (2009) · Environmental Science and Pollution Research · doi:10.1007/s11356-009-0107-7 · Cited by 343
OKEY, A., FRANC, M., MOFFAT, I., TIJET, N., BOUTROS, P., KORKALAINEN, M., TUOMISTO, J., & POHJANVIRTA, R. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.028 · Cited by 122
Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice
Tong, M. H., Jiang, H., Liu, P., Lawson, J. A., Brass, L. F., & Song, W.-C. (2005) · Nature Medicine · doi:10.1038/nm1184 · Cited by 110
Bisphenol A interferes with synaptic remodeling
Hajszan, T., & Leranth, C. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.06.004 · Cited by 101
Metadata
- Authors
- Safe, S. H.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-06
- Volume
- 108
- Issue
- 6
- Pages
- 487-493
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2025303369
- Cited by
- 351
- References
- 107
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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