The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.
Open accessAbstract
Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic chemical exposure has been widely described in experimental animal models. The resultant inhibited postnatal immune responses in such animals are often more dramatic and persistent than those after exposure during adult life. Further, recent reports suggest that prenatal exposure to immunotoxicants may exacerbate postnatal aberrant immune responses (e.g., hypersensitivity disorders and autoimmune disease) in genetically predisposed rodents. Limited information is available regarding the possibility of inhibited postnatal immune capacity in humans as a result of developmental immunotoxicant exposure. The multifactorial nature of hypersensitivity and autoimmune responses will further complicate the elucidation of possible relationships between chemical exposure during ontogeny of the human immune system and immune-mediated disease later in life. Taken together, however, the available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.
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Cites
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Cited by
Identifying critical windows of exposure for children's health.
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Pregnancy in Recipients of Solid Organs — Effects on Mother and Child
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Does age matter? The impact of rodent age on study outcomes
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Metadata
- Authors
- Holladay, S. D., & Smialowicz, R. J.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-06
- Volume
- 108
- Issue
- suppl 3
- Pages
- 463-473
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1984735358
- Cited by
- 307
- References
- 63
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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