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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Open accessAbstract
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation, synaptogenesis, myelination, and apoptosis). Evidence from numerous sources demonstrates that neural development extends from the embryonic period through adolescence. In general, the sequence of events is comparable among species, although the time scales are considerably different. Developmental exposure of animals or humans to numerous agents (e.g., X-ray irradiation, methylazoxymethanol, ethanol, lead, methyl mercury, or chlorpyrifos) demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity. Different behavioral domains (e.g., sensory, motor, and various cognitive functions) are subserved by different brain areas. Although there are important differences between the rodent and human brain, analogous structures can be identified. Moreover, the ontogeny of specific behaviors can be used to draw inferences regarding the maturation of specific brain structures or neural circuits in rodents and primates, including humans. Furthermore, various clinical disorders in humans (e.g., schizophrenia, dyslexia, epilepsy, and autism) may also be the result of interference with normal ontogeny of developmental processes in the nervous system. Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function. This concern is compounded by the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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“By the time the apical radial glial progenitors within the prefrontal subdomains start dividing asymmetrically, the number of neurons will increase rapidly and peaks between week 13 and 16 of gestation in human (E10-E15 rodents/E43-E50 primates), specifically in the dorsal telencephalon [44–47].”
From Development of prefrontal cortex (2022) · cites this paper as [47]
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“This is based on developmental endpoints, since rodent exposures in early infancy (i.e., the neonatal period) mimic human 3rd trimester exposures for several organs, including the lung [50] and brain [51].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [51]
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“This window of exposure is critical to central nervous system development and equivalent to human 3rd trimester brain development [51].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [51]
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“Developmental neurotoxicity (DNT) testing is particularly critical, as chemical-induced disruptions in neurogenesis, synaptogenesis, migration, or network formation during vulnerable developmental windows can cause lifelong neurological deficits (Rice and Barone, 2000; Grandjean and Landrigan, 2014).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Rice and Barone, 2000
In the citing paper
“These neurodevelopmental processes physiologically occurs during the first and second trimester of pregnancy [231].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [231]
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“This field is especially promising for cerebellar neuropathology, in light of the prolonged developmental time window exposing cerebellar circuits to damage by environmental agents in genetically susceptible individuals not only prenatally, but also postnatally [231].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [231]
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Citations
Cites
Items 201–400 of 407
Growth, development and behaviour in adolescents born small‐for‐gestational‐age
Pryor, J. E., Silva, P. A., & BROOKE, M. (1995) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1995.tb00847.x · Cited by 119
Vallés, S. L., Pitarch, J., Renau‐Piqueras, J., & Guerri, C. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062484.x · Cited by 119
Evoked Potentials in Faroese Children Prenatally Exposed to Methylmercury
Murata, K., Weihe, P., Araki, S., Budtz–Jørgensen, E., & Grandjean, P. (1999) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00026-4 · Cited by 117
Delayed behavioral toxicity of lead with increasing exposure concentration
Cory‐Slechta, D. A., Weiss, B., & Cox, C. (1983) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(83)90021-2 · Cited by 117
Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis
Grifman, M., Galyam, N., Seidman, S., & Soreq, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13935 · Cited by 116
Streissguth, A. P., Bookstein, F. L., Sampson, P. D., & Barr, H. M. (1993) · Cited by 116
Principles of Behavioral Teratology
Vorhees, C. V. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2189-7_2 · Cited by 115
Neurobehavioral and systemic effects of longterm blood lead-elevation in rats
Winneke, G., Brockhaus, A., & Baltissen, R. (1977) · Archives of Toxicology · doi:10.1007/bf00330817 · Cited by 114
Siegel, L. S. (1983) · PubMed · Cited by 113
Bertolino, A., Knable, M., Saunders, R., Callicott, J., Kolachana, B., Mattay, V., Bachevalier, J., Frank, J., Egan, M., & Weinberger, D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00380-1 · Cited by 110
Neuropsychological performance on tests of frontal-lobe functioning and aggressive behavior in men.
Giancola, P. R., & Zeichner, A. (1994) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.103.4.832 · Cited by 107
Nagashima, K. (1997) · Toxicologic Pathology · doi:10.1177/019262339702500613 · Cited by 107
Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells
Alfano, D. P., & Petit, T. L. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90160-1 · Cited by 104
Behavioral Impairment Produced by Low-Level Postnatal PCB Exposure in Monkeys
Rice, D. C. (1999) · Environmental Research · doi:10.1006/enrs.1998.3917 · Cited by 104
Self-citationOverman, W., Bachevalier, J., Schuhmann, E. M., & Ryan, P. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.673 · Cited by 103
Programmed cell death: Does it play a role in parkinson's disease?
Burke, R. E., & Kholodilov, N. G. (1998) · Annals of Neurology · doi:10.1002/ana.410440719 · Cited by 103
Infant Information Processing in Relation to Six-Year Cognitive Outcomes
Rose, S. A., Feldman, J. F., & Wallace, I. (1992) · Child Development · doi:10.1111/j.1467-8624.1992.tb01684.x · Cited by 101
Ċastrén, E., Berzaghi, M. D. P., Lindholm, D., & Thoenen, H. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1124 · Cited by 101
Rantakallio, P. T., Läärä, E., Isohanni, M. K., & Moilanen, I. K. (1992) · International Journal of Epidemiology · doi:10.1093/ije/21.6.1106 · Cited by 101
Developmental plasticity and memory
Rauschecker, J. P. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00117-x · Cited by 100
Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain
White, L. D., & Barone, S. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400816 · Cited by 100
Self-citationIs Apoptosis Key in Alzheimer's Disease?
Barinaga, M. (1998) · Science · doi:10.1126/science.281.5381.1303 · Cited by 99
Behavioral Effects of Lead: Commonalities between Experimental and Epidemiologic Data
Rice, D. C. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s2337 · Cited by 98
Self-citationButterworth, N. J., Williams, L. C., Bullock, J. Y., Love, D. R., Faull, R. L. M., & Dragunow, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00129-8 · Cited by 96
The Relationship Between Playfulness and Coping in Preschool Children: A Pilot Study
Saunders, I., Sayer, M., & Goodale, A. (1999) · American Journal of Occupational Therapy · doi:10.5014/ajot.53.2.221 · Cited by 96
Cutler, A. (1996) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(96)00125-0 · Cited by 95
Operant Test Battery Performance in Children
Paule, M. G., Chelonis, J. J., Buffalo, E. A., Blake, D. J., & Casey, P. H. (1999) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(98)00045-2 · Cited by 93
Mitotic arrest in the developing CNS after prenatal exposure to methylmercury.
Rodier, P. M., Aschner, M., & Sager, P. R. (1984) · PubMed · Cited by 91
Denenberg, V. H., Sherman, G. F., Schrott, L. M., Rosen, G. D., & Galaburda, A. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)91192-4 · Cited by 90
Da, F., Campbell, M. L., & Ys, B. (1997) · PubMed · Cited by 90
Increase in Child Behavior Problems Resulting from Maternal Smoking during Pregnancy
Orlebeke, J. F., Knol, D. L., & Verhulst, F. C. (1997) · Archives of Environmental Health An International Journal · doi:10.1080/00039899709602205 · Cited by 89
Parnakh, V. (1996) · Experiment · doi:10.1163/2211730x96x00234 · Cited by 89
Effects of Methyl Mercury on the Cell Cycle of Primary Rat CNS Cells in Vitro
Ponce, R. A., Kavanagh, T. J., Mottet, N. K., Whittaker, S. G., & Faustman, E. M. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1142 · Cited by 87
Play, creativity, and adaptive functioning: Implications for play interventions
Russ, S. W. (1998) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2704_11 · Cited by 87
Postnatal migration of neurons and formation of laminae in rat cerebral cortex
Ignacio, M., Kimm, E. J., Kageyama, G. H., Yu, J. Z., & Robertson, R. T. (1995) · Anatomy and Embryology · doi:10.1007/bf00186782 · Cited by 86
Auditory cortex: comparative aspects of maps and plasticity
Scheich, H. (1991) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(91)90084-k · Cited by 85
Behavioral Teratology and Toxicology
Spyker, J. M. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2859-9_12 · Cited by 85
The Paired‐Comparison Paradigm and Infant Intelligence
Fagan, J. F. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48902.x · Cited by 84
Lapchak, P. A., Araujo, D. M., & Hefti, F. F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90407-7 · Cited by 82
Overman, W., Bachevalier, J., Schuhmann, E., et al. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.4.673 · Cited by 82
Myelination: a critical stage in development.
Wiggins, R. C. (1986) · PubMed · Cited by 81
Largo, R. H., & Howard, J. A. (1979) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1979.tb01622.x · Cited by 81
Sen, A., Jensen, A. R., Sen, A. K., & Arora, I. (1983) · Applied Research in Mental Retardation · doi:10.1016/0270-3092(83)90006-1 · Cited by 79
Vallés, S. L., Sancho‐Tello, M., Miñana, R., Climent, E., Renau‐Piqueras, J., & Guerri, C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062425.x · Cited by 78
Gunderson, V. M., Grant, K. S., Burbacher, T. M., Fagan, J. F., & Mottet, N. K. (1986) · Child Development · doi:10.1111/j.1467-8624.1986.tb00268.x · Cited by 78
Rice, D. C. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)87364-3 · Cited by 76
Self-citationEffects of lead exposure during development on neocortical dendritic and synaptic structure
Petit, T. L., & LeBoutillier, J. C. (1979) · Experimental Neurology · doi:10.1016/0014-4886(79)90226-7 · Cited by 75
Prenatal effects of drugs of abuse on brain development
Levitt, P. R. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00070-2 · Cited by 74
Jones, E. G., Valentino, K. L., & Fleshman, J. W. (1981) · Developmental Brain Research · doi:10.1016/0165-3806(81)90050-x · Cited by 74
Prenatal Binge-Like Alcohol Exposure in the Rat Results in Region-Specific Deficits in Brain Growth
Maier, S. E., Miller, J. A., & West, J. R. (1999) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(98)00056-7 · Cited by 74
Denenberg, V. H., Mobraaten, L. E., Sherman, G. F., Morrison, L. J., Schrott, L. M., Waters, N. S., Rosen, G. D., Behan, P. O., & Galaburda, A. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)91522-3 · Cited by 73
Slotkin, T. A., Lappi, S. E., & Seidler, F. J. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90224-y · Cited by 72
Psychomotor functions in developing rats: Ontogenetic approach to structure-function relationships
Bâ, A. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00042-y · Cited by 72
Watson, W. E. (1974) · Physiological Reviews · doi:10.1152/physrev.1974.54.2.245 · Cited by 71
Rice, D. C., Gilbert, S. G., & Willes, R. F. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90375-2 · Cited by 69
Self-citationLifetime low-level lead exposure produces deficits in delayed alternation in adult monkeys
Dc, R., & Karpinski, K. (1988) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(88)90019-0 · Cited by 68
Boehm, G. W., Sherman, G. F., Hoplight, B. J., Hyde, L. A., Waters, N. S., Bradway, D. M., Galaburda, A. M., & Denenberg, V. H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00299-5 · Cited by 68
Behavioral effects of pre- and postnatal exposure to a mixture of low chlorinated PCBs in rats
Lilienthal, H. (1990) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(90)90032-f · Cited by 67
Value and Limitations of Infant Tests: An Overview
Honzik, M. P. (1976) · Springer eBooks · doi:10.1007/978-1-4684-6961-5_3 · Cited by 67
Cerebellar histogenesis and synaptic maturation following pre- and postnatal alcohol administration
Volk, B. (1984) · Acta Neuropathologica · doi:10.1007/bf00688471 · Cited by 66
Breese, C. R., D'Costa, A. P., Ingram, R. L., LENHAM, J. E., & Sonntag, W. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10289-9 · Cited by 66
Press, F. (1969) · Science · doi:10.1126/science.165.3889.174 · Cited by 66
Volumetric quantification of brain development using MRI
Iwasaki, N., Hamano, K., Okada, Y., Horigome, Y., Nakayama, J., Takeya, T., Takita, H., & Nose, T. (1997) · Neuroradiology · doi:10.1007/s002340050517 · Cited by 65
Zoeller, R. T., Butnariu, O., Fletcher, D. L., & Riley, E. P. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00059.x · Cited by 65
Bilateral Spastic Cerebral Palsy - Pathogenetic Aspects from MRI
Krägeloh‐Mann, I., Hagberg, B. A., Petersen, D., Riethmüller, J., Gut, E., & Michaelis, R. (1992) · Neuropediatrics · doi:10.1055/s-2008-1071311 · Cited by 65
Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children
Dahl, R., White, R. F., Weihe, P., Sørensen, N., Letz, R., Hudnell, H. K., Otto, D. A., & Grandjean, P. (1996) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(96)00031-1 · Cited by 64
Morphogenetic Roles of Acetylcholine
Lauder, J. M., & Schambra, U. B. (1999) · Environmental Health Perspectives · doi:10.2307/3434473 · Cited by 64
Kinjo, Y., HIGASHI, H., Nakano, A., Sakamoto, M., & Sakai, R. (1993) · Environmental Research · doi:10.1006/enrs.1993.1144 · Cited by 64
Dohrman, D. P., West, J. R., & Pantazis, N. J. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03853.x · Cited by 63
Schmahl, W., Funk, R., Miaskowski, U., & Plendl, J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90515-5 · Cited by 63
Methods in Behavioral Teratology
Adams, J. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2189-7_4 · Cited by 62
Behavioral deficit (delayed matching to sample) in monkeys exposed from birth to low levels of lead
Rice, D. C. (1984) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(84)90216-3 · Cited by 62
Self-citationThe effect of prenatal and postnatal lead exposure on neonatal synaptogenesis in rat cerebral cortex
McCauley, P. T., Bull, R. J., Tonti, A. P., Lutkenhoff, S. D., Meister, M. V., Doerger, J. U., & Stober, J. A. (1982) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398209530283 · Cited by 62
Gunderson, V. M., Grant, K. S., Burbacher, T. M., et al. (1986) · Child Development · doi:10.2307/1130381 · Cited by 62
Overman, W., Bachevalier, J., Turner, M. A., & Peuster, A. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.15 · Cited by 61
Hoxa1 and Krox-20 synergize to control the development of rhombomere 3
Helmbacher, F., Pujades, C., Dinh, C. D., Frain, M., Rijli, F. M., Chambon, P., & Charnay, P. (1998) · Development · doi:10.1242/dev.125.23.4739 · Cited by 61
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells
Bessho, Y., Nakanishi, S., & Nawa, H. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90190-z · Cited by 60
The human striatum in schizophrenia. II. Increased number of striatal neurons in schizophrenics
Beckmann, H., & Lauer, M. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(96)02947-2 · Cited by 60
MOTONEURON DISEASE AND PAST POLIOMYELITIS IN ENGLAND AND WALES
Martyn, C. N., Barker, D. J. P., & Osmond, C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92129-0 · Cited by 60
Paraoxonase (Pon1) gene in mice: sequencing, chromosomal localization and developmental expression
Li, W., Matthews, C. P., Distèche, C. M., Costa, L. G., & Furlong, C. E. (1997) · Pharmacogenetics · doi:10.1097/00008571-199704000-00007 · Cited by 59
Apoptosis, Neurotrophic Factors and Neurodegeneration
Dragunow, M., MacGibbon, G. A., Lawlor, P. A., Butterworth, N. J., Connor, B. J., Henderson, C. E., Walton, M. R., Woodgate, A.-M., Hughes, P. E., & Faull, R. L. M. (1997) · Reviews in the Neurosciences · doi:10.1515/revneuro.1997.8.3-4.223 · Cited by 58
Cross-species correspondence of spatial contrast sensitivity functions
Uhlrich, D. J., Essock, E. A., & Lehmkuhle, S. W. (1981) · Behavioural Brain Research · doi:10.1016/0166-4328(81)90013-9 · Cited by 57
Freeman, J. H., Barone, S., & Stanton, M. E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07301.1995 · Cited by 57
Self-citationPrenatal Smoking and Antisocial Behavior
Fergusson, D. M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.223 · Cited by 56
Cerebellum and cerebrum in adaptive control and cognition: a review
Parkins, E. J. (1997) · Biological Cybernetics · doi:10.1007/s004220050369 · Cited by 56
Rice, D. C. (1998) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00134-7 · Cited by 55
Self-citationRetarded object permanence development in methylmercury exposed Macaca fascicularis infants.
Burbacher, T. M., Grant, K. S., & Mottet, N. K. (1986) · Developmental Psychology · doi:10.1037/0012-1649.22.6.771 · Cited by 55
Barone, S., Haykal-Coates, N., Parran, D. K., & Tilson, H. A. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00038-8 · Cited by 55
Self-citationRice, D. C., & Gilbert, S. G. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1180 · Cited by 53
Self-citationMalchiodi‐Albedi, F., Petrucci, T. C., Picconi, B., Iosi, F., & Falchi, M. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970601)48:5 · Cited by 53
Maturation of medial temporal lobe memory functions in rodents, monkeys, and humans
Bachevalier, J., & Beauregard, M. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030723 · Cited by 51
Koop, M., Rilling, G., Herrmann, A., & Hj, K. (1986) · PubMed · Cited by 51
English, P. B., & Eskenazi, B. (1992) · International Journal of Epidemiology · doi:10.1093/ije/21.6.1097 · Cited by 51
Specific inhibition of myelination by lead in vitro; Comparison with arsenic, thallium, and mercury
Windebank, A. J. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90283-9 · Cited by 49
Delayed neurotoxicity in monkeys exposed developmentally to methylmercury.
Dc, R. (1989) · PubMed · Cited by 48
Methylmercury accumulation in brains of pregnant, non-pregnant and fetal rats
Null, D. H., Gartside, P. S., & Wei, E. T. (1973) · Life Sciences · doi:10.1016/0024-3205(73)90028-3 · Cited by 48
Bh, C. (1986) · PubMed · Cited by 48
O'Callaghan, J. P., & Miller, D. B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24260-4 · Cited by 48
Eagleson, K. L., Lillien, L. E., Chan, A. V., & Levitt, P. R. (1997) · Development · doi:10.1242/dev.124.8.1623 · Cited by 47
The causes of cerebral palsy. Recent evidence.
Paneth, N. (1993) · PubMed · Cited by 46
Lancaster, F. E., Mayur, B. K., Patsalos, P. N., Samorajski, T., & Wiggins, R. C. (1982) · Brain Research · doi:10.1016/0006-8993(82)90199-8 · Cited by 46
Rothenberg, S. J., Poblano, A., & Garza-Morales, S. J. (1994) · PubMed · Cited by 46
Imaging as a tool in exploring the neurodevelopment and genetics of schizophrenia
Frangou, S., & Murray, R. M. (1996) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011569 · Cited by 45
Rice, D. C. (1990) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(90)90236-n · Cited by 44
Self-citationRice, D. C. (1998) · Toxicological Sciences · doi:10.1006/toxs.1998.2487 · Cited by 44
Self-citationNeural cells derived by in vitro differentiation of P19 and embryonic stem cells.
Bain, G., & Gottlieb, D. I. (1998) · PubMed · Cited by 44
Gender differnces in visual habit formation in 3‐month‐old rhesus monkeys1
Bachevalier, J., Hagger, C., & Bercu, B. B. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220605 · Cited by 43
Risk assessment: the insidious nature of neurotoxicity and the aging brain.
Weiss, B. (1990) · PubMed · Cited by 43
Synaptic vesicle proteins and regulated exocytosis
Elferink, L. A., & Scheller, R. H. (1993) · Journal of Cell Science · doi:10.1242/jcs.1993.supplement_17.11 · Cited by 42
Quantitative Perspectives on the Long-Term Toxicity of Methylmercury and Similar Poisons
Weiss, B., & Simon, W. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2859-9_16 · Cited by 41
Synaptogenesis in the hippocampal dentate gyrus: Effects of in utero ethanol exposure
Hoff, S. F. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90119-0 · Cited by 41
OWEN, A. D., & Bird, M. M. (1995) · Neuroreport · doi:10.1097/00001756-199511270-00001 · Cited by 40
Rice, D. C. (1992) · PubMed · Cited by 40
Self-citationNeurotoxic effects of neonatal triethyltin (TET) exposure are exacerbated with aging
Barone, S., Stanton, M. E., & Mundy, W. R. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00089-w · Cited by 39
Self-citationNeonatal Insult to the Hippocampal Region and Schizophrenia: A Review and a Putative Animal Model
Beauregard, M., & Bachevalier, J. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100710 · Cited by 39
Distribution of manganese in development.
Fechter, L. D. (1999) · PubMed · Cited by 39
Goodman, R. (1995) · European Child & Adolescent Psychiatry · doi:10.1007/bf01980457 · Cited by 39
Rubin, R. A., & Balow, B. (1979) · Developmental Psychology · doi:10.1037//0012-1649.15.2.225 · Cited by 39
Silva, P. A., McGee, R. O., & Williams, S. (1984) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-198402000-00001 · Cited by 38
O'Callaghan, J. P., & Miller, D. B. (1989) · PubMed · Cited by 37
Prenatal Ethanol Effects on NGF Level, NPY and ChAT Immunoreactivity in Mouse Entorhinal Cortex
Angelucci, F., Fiore, M., Cozzari, C., & Aloe, L. (1999) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00005-7 · Cited by 36
Stereotypies and loss of social affiliation after early hippocampectomy in primates
Beauregard, M., Málková, L., & Bachevalier, J. (1995) · Neuroreport · doi:10.1097/00001756-199512150-00018 · Cited by 36
Simonati, A., Rosso, T., & Rizzuto, N. (1997) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1997.tb01203.x · Cited by 36
Functionally and anatomically segregated visual pathways in the lobula complex of a calliphorid fly
Douglass, J. K., & Strausfeld, N. J. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980622)396:1 · Cited by 36
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons
Gleason, E. L., & Spitzer, N. C. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.6.2986 · Cited by 35
Furlong, C. E., Li, W. F., Costa, L. G., Richter, R. J., Shih, D. M., & Lusis, A. J. (1998) · PubMed · Cited by 35
Formation of Dendrites and Development of Synaptic Connections
Jacobson, M. (1991) · Springer eBooks · doi:10.1007/978-1-4757-4954-0_6 · Cited by 33
Changes in the physiological roles of neurotransmitters during individual development
Buznikov, G. A., Shmukler, Y. B., & Lauder, J. M. (1999) · Neuroscience and Behavioral Physiology · doi:10.1007/bf02461353 · Cited by 33
Zanoli, P., Truzzi, C., Veneri, C., Braghiroli, D., & Baraldi, M. (1994) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1994.tb00358.x · Cited by 33
Fixed interval/fixed ratio performance in adult monkeys exposed in utero to methylmercury
Gilbert, S. G., Rice, D. C., & Burbacher, T. M. (1996) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(96)00081-5 · Cited by 33
Self-citationDevelopment and plasticity of the neural circuitry underlying visual recognition memory
Webster, M. J., Ungerleider, L. G., & Bachevalier, J. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-191 · Cited by 32
Role of GABAA receptors in the organization of brain and behavioural sex differences
Segovia, S., del Cerro, M. C. R., Ortega, E., Pérez-Laso, C., Zafra, M. R., Izquierdo, M. A. P., & Guillamón, A. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00030 · Cited by 32
Morphogenetic Effects of Neuregulin (Neu Differentiation Factor) in Cultured Epithelial Cells
Chausovsky, A., Tsarfaty, I., Kam, Z., Yarden, Y., Geiger, B., & Bershadsky, A. D. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.11.3195 · Cited by 32
Angelucci, F., Cimino, M., Balduini, W., Piltillo, L., & Aloe, L. (1997) · Neural Plasticity · doi:10.1155/np.1997.63 · Cited by 32
Cory‐Slechta, D. A., Pokora, M. J., & Widzowski, D. (1991) · PubMed · Cited by 32
(1849) · Scientific American · doi:10.1038/scientificamerican02241849-178d · Cited by 32
Controlled Ethyl tert-Butyl Ether (ETBE) Exposure of Male Volunteers
Nihlén, A., Löf, A., & Johanson, G. (1998) · Toxicological Sciences · doi:10.1093/toxsci/46.1.1 · Cited by 32
The specification of neuronal identity in the mammalian cerebral cortex
McConnell, S. K. (1990) · Cellular and Molecular Life Sciences · doi:10.1007/bf01939385 · Cited by 31
Stanton, M. E. (1995) · Fundamental and Applied Toxicology · doi:10.1006/faat.1995.1151 · Cited by 30
Bailey, C. H., & Chen, M. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb25924.x · Cited by 30
Forebrain damage following prenatal exposure to low-dose X-irradiation
Norton, S., & Donoso, J. A. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90209-2 · Cited by 30
Deficits in Visual Recognition in Low Birth Weight Infant Pigtailed Monkeys (Macaca nemestrina)
Gunderson, V. M., Grant-Webster, K. S., & Sackett, G. P. (1989) · Child Development · doi:10.1111/j.1467-8624.1989.tb02701.x · Cited by 30
Dc, R., & Hayward, S. J. (1999) · PubMed · Cited by 29
The neurotoxicity of parathion-induced acetylcholinesterase inhibition in neonatal rats.
Veronesi, B., & Pope, C. (1990) · PubMed · Cited by 28
Structure and function of the HOX A1 human homeobox gene cDNA
Hong, Y. S., Kim, S. Y., Bhattacharya, A., Pratt, D. R., Hong, W. K., & Tainsky, M. A. (1995) · Gene · doi:10.1016/0378-1119(95)92712-g · Cited by 28
Lewis, D. P., Dyke, D. C. V., Stumbo, P. J., & Berg, M. J. (1998) · Annals of Pharmacotherapy · doi:10.1345/aph.17298 · Cited by 28
The effect of lead toxicity and milk deprivation on myelination in the rat
Harry, G. J., Toews, A. D., Krigman, M. R., & Morell, P. (1985) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(85)90186-3 · Cited by 28
Albrech, J., Čarman‐Kržan, M., Fabrazzo, M., & Wise, B. C. (1991) · Brain Research · doi:10.1016/0006-8993(91)91572-i · Cited by 27
Haykal-Coates, N., Shafer, T. J., Mundy, W. R., & Barone, S. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00039-x · Cited by 27
Self-citationPsychotropic drugs and brain development: effects on cell replication in vivo and in vitro.
Patel, A. J., Barochovsky, O., & Pd, L. (1981) · PubMed · Cited by 27
Chapter 7 Synaptic vesicle proteins and regulated exocytosis
Elferink, L. A., & Scheller, R. H. (1995) · Progress in brain research · doi:10.1016/s0079-6123(08)63285-9 · Cited by 26
Controlled Ethyltert-Butyl Ether (ETBE) Exposure of Male Volunteers*1I. Toxicokinetics
Nihlén, A. (1998) · Toxicological Sciences · doi:10.1006/toxs.1998.2516 · Cited by 25
Audesirk, T., & Cabell, L. (1999) · PubMed · Cited by 25
Issues in developmental neurotoxicology: interpretation and implications of the data.
Dc, R. (1998) · PubMed · Cited by 25
Glial cell lineage and development
Price, J. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90009-4 · Cited by 25
Sotelo, C., & Beaudet, A. (1979) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1979.0096 · Cited by 25
Wallace, R. B., Daniels, C. E., & Altman, J. (1972) · Developmental Psychobiology · doi:10.1002/dev.420050105 · Cited by 25
Lilienthal, H., Benthe, C., Heinzow, B., & Winneke, G. (1996) · Archives of Toxicology · doi:10.1007/s002040050257 · Cited by 24
Deficits in Visual Recognition in Low Birth Weight Infant Pigtailed Monkeys (Macaca nemestrina)
Gunderson, V. M., Grant-Webster, K. S., & Sackett, G. P. (1989) · Child Development · doi:10.2307/1131077 · Cited by 24
Pennington, S. N., Sandstrom, L. P., Shibley, I. A., Long, S. D., Beeker, K. R., Smith, C. P., Lee, K., Jones, T. A., Cummings, K. M., & Means, L. W. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)00135-9 · Cited by 23
REVIEW ■ : Reorganization of Sensory Systems of Primates after Injury
Kaas, J. H., Florence, S. L., & Jain, N. (1997) · The Neuroscientist · doi:10.1177/107385849700300211 · Cited by 23
Rat and human sensory evoked potentials and the predictability of human neurotoxicity from rat data.
Wk, B. (1994) · PubMed · Cited by 22
Zhou, J., & Bradford, H. F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00030-0 · Cited by 22
Laev, H., Karpiak, S. E., Gokhale, V. S., & Hungund, B. L. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01605.x · Cited by 21
Quantification of operant behavior
Rice, D. C. (1988) · Toxicology Letters · doi:10.1016/0378-4274(88)90038-0 · Cited by 21
Self-citationDietary aluminum selectively decreases MAP-2 in brains of developing and adult rats.
Johnson, G. V. W., Watson, A. L., Lartius, R. K., Uemura, E., & Jope, R. S. (1992) · PubMed · Cited by 21
Differential effects of formamidine pesticides on fixed-interval behavior in rats
MOSER, V. C., & MacPhail, R. C. (1986) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(86)90139-0 · Cited by 20
Implementation of a primary screen for development neurotoxicity
Wier, P. J. (1989) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(89)90312-6 · Cited by 20
Santucci, D., Rankin, J. M., Laviola, G., Aloe, L., & Alleva, E. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90847-8 · Cited by 20
Neuroblast cell death in ovo and in culture: Interaction of ethanol and neurotrophic factors
Rhaman, H., Kentroti, S., & Vernadakis, A. (1994) · Neurochemical Research · doi:10.1007/bf00968996 · Cited by 19
Investigations of amitraz neurotoxicity in rats *1I. Effects on operant performance
MOSER, V. C. (1987) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(87)90160-6 · Cited by 19
Largo, R. H., & Howard, J. A. (1979) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1979.tb01654.x · Cited by 19
Developmental trends in children's pretend play
Lyytinen, P. (1991) · Child Care Health and Development · doi:10.1111/j.1365-2214.1991.tb00675.x · Cited by 19
Myelin basic protein in brains of rats with low dose lead encephalopathy
Sundstr�m, R., & Karlsson, B. W. (1987) · Archives of Toxicology · doi:10.1007/bf00295087 · Cited by 18
Relationship between reaction time and neuropsychological test performance
Western, S. L., & Long, C. J. (1996) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/11.7.557 · Cited by 18
Alberch, J., Brito, B., Notario, V., & Castro, R. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90620-9 · Cited by 17
Webb, B. D., Suárez, S. S., Heaton, M. B., & Walker, D. W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01088-3 · Cited by 17
Deficient cumulative learning: An animal model of retarded cognitive development
Strupp, B. J., Bunsey, M. D., Levitsky, D. A., & Hamberger, K. (1994) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)90011-6 · Cited by 17
Effects of lifetime lead exposure on spatial and temporal visual function in monkeys.
Rice, D. C. (1998) · PubMed · Cited by 17
Self-citationFagan, J. F. (1984) · Springer eBooks · doi:10.1007/978-1-4615-9364-5_1 · Cited by 17
Morphometric effects of preweaning lead exposure on the hippocampal formation of adult rats.
Kawamoto, J. C., Overmann, S. R., Woolley, D. E., & Vk, V. (1984) · PubMed · Cited by 15
Simone, R. D., & Aloe, L. (1993) · PubMed · Cited by 15
Rice, D. C. (1998) · Elsevier eBooks · doi:10.1016/b978-012648860-9/50040-6 · Cited by 14
Self-citationEvans, H. L. (1994) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)90125-2 · Cited by 13
Rice, D. C. (1998) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00099-8 · Cited by 12
Self-citationMilberger, S., Biederman, J., Faraone, S. V., Chen, L., & Jones, J. T. (1997) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199704000-00003 · Cited by 12
Maturational changes in neonatal rat motor system with early postnatal administration of nicotine
Frischer, R. E., King, J. A., Rose, K. J., & Strand, F. L. (1988) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(88)90039-1 · Cited by 11
Pérez‐Navarro, E., Alberch, J., Arenas, E., & Marsal, J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90344-k · Cited by 10
TO BE OR NOT TO BE: HOW ETHANOL CAN AFFECT NEURONAL DEATH DURING DEVELOPMENT
Hoffman, P. L., & Tabakoff, B. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01065.x · Cited by 10
Mundy, W. R., Parran, D. K., & Barone, S. (1999) · Neurotoxicity Research · doi:10.1007/bf03033257 · Cited by 9
Self-citationYeh, G., Hsieh, T.-H., & Chang, S. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00528-x · Cited by 8
Synaptic density of caudate‐putamen and visual cortex following exposure to ethanol in utero
Lancaster, F. E., Delaney, C., & Samorajski, T. (1989) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(89)90017-8 · Cited by 6
Rice, D. C. (1997) · American Zoologist · doi:10.1093/icb/37.4.409 · Cited by 6
Self-citationSiegel, L. S. (1983) · Child Development · doi:10.1111/j.1467-8624.1983.tb00538.x · Cited by 6
Implementation of a Primary Screen for Developmental Neurotoxicity
Wier, P. J., Guerriero, F. J., & Walker, R. F. (1989) · Toxicological Sciences · doi:10.1093/toxsci/13.1.118 · Cited by 4
Lack of Attention from Loss of Time
Gold, P. W. (1998) · Science · doi:10.1126/science.281.5380.1149a · Cited by 3
Introduction: Memory systems in the primate brain
Murray, E. A. (1996) · Seminars in Neuroscience · doi:10.1006/smns.1996.0001 · Cited by 3
Boehm, G. W. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00299-5 · Cited by 3
Freeman, J. (1996) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(96)88040-8 · Cited by 3
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Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M., & Noble-Haeusslein, L. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.001 · Cited by 2,132
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
Developmental neurotoxicity of industrial chemicals
Grandjean, P., & Landrigan, P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69665-7 · Cited by 1,984
Neurobehavioural effects of developmental toxicity
Grandjean, P., & Landrigan, P. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70278-3 · Cited by 1,886
Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort
Wilder, R. T., Flick, R. P., Šprung, J., Katusic, S. K., Barbaresi, W. J., Mickelson, C., Gleich, S. J., Schroeder, D. R., Weaver, A. L., & Warner, D. O. (2009) · Anesthesiology · doi:10.1097/01.anes.0000344728.34332.5d · Cited by 1,367
Metadata
- Authors
- Rice, D., & Barone, S.
- Affiliations
- Environmental Protection Agency (US)
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-06-01
- Volume
- 108
- Issue
- suppl 3
- Pages
- 511-533
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC1637807
- OpenAlex
- W2120095635
- Cited by
- 2,944
- References
- 455
- Citations by year
- 2026: 46 · 2025: 94 · 2024: 148 · 2023: 180 · 2022: 173 · 2021: 181 · 2020: 177 · 2019: 163 · 2018: 168 · 2017: 141 · 2016: 150 · 2015: 183 · 2014: 141 · 2013: 124 · 2012: 124
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Environmental Health Perspectives (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Environmental Protection Agency
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- critical period, developmental neurotoxicity, brain development, neuronal proliferation, neuronal migration, neuronal differentiation, synaptogenesis, myelination, apoptosis, early life exposure, X-ray irradiation, methylazoxymethanol, ethanol, lead, methylmercury, chlorpyrifos, behavioral development, brain maturation, schizophrenia, dyslexia, epilepsy, autism spectrum disorder, age-related cognitive decline
- MeSH terms
- Adult, Aged, Aging, Animals, Cell Differentiation, Cell Movement, Child, Child, Preschool, Female, Embryonic and Fetal Development, Humans, Infant, Infant, Newborn, Middle Aged, Nervous System, Neuronal Plasticity, Neurotoxins, Pregnancy, Primates, Time Factors, Xenobiotics, Apoptosis, Mice, Rats
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