The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004
Open accessAbstract
BACKGROUND: Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. OBJECTIVES: We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. METHODS: We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL. RESULTS: Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 microg/L. CONCLUSIONS: In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes.
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Cites
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The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · cited 2×
“An excess of reactive oxygen species may increase insulin resistance and affect pancreatic β-cell function (Houstis et al. 2006), and some selenium compounds such as selenite and methylselenol (a metabolite of selenomethionine) (Rayman 2005) can induce oxidative stress (Drake 2006; Spallholz 1994;…”
BackgroundLippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2009) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,122
Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
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Selenium in global food systems
Combs, G. F. (2001) · British Journal of Nutrition · doi:10.1079/bjn2000280 · Cited by 1,129
Selenium in cancer prevention: a review of the evidence and mechanism of action
Rayman, M. P. (2005) · Proceedings of the Nutrition Society · doi:10.1079/pns2005467 · Cited by 858
Food-chain selenium and human health: emphasis on intake
Rayman, M. P. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508939830 · Cited by 798
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Self-citationTobin, M. D., Sheehan, N. A., Scurrah, K. J., & Burton, P. R. (2005) · Statistics in Medicine · doi:10.1002/sim.2165 · Cited by 691
Cited by
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, X. G., Zhu, J.-H., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 429
Selenium in reproductive health
Mistry, H. D., Broughton Pipkin, F., Redman, C. W. G., & Poston, L. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.07.034 · Cited by 329
Metadata
- Authors
- Laclaustra, M., Navas-Acien, A., Stranges, S., Ordovas, J. M., & Guallar, E.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09
- Volume
- 117
- Issue
- 9
- Pages
- 1409-1413
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2007255460
- Cited by
- 272
- References
- 27
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Laclaustra, M., Navas-Acien, A., Stranges, S., Ordovas, J. M., & Guallar, E. (2009). Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004. Environmental Health Perspectives. https://doi.org/10.1289/ehp.0900704
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