The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Open accessAbstract
Background: Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States. Objectives: We aimed to assess exposure to BPA and tOP in the U.S. general population. Methods: We measured the total (free plus conjugated) urinary concentrations of BPA and tOP in 2,517 participants ≥ 6 years of age in the 2003–2004 National Health and Nutrition Examination Survey using automated solid-phase extraction coupled to isotope dilution–high-performance liquid chromatography–tandem mass spectrometry. Results: BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively. Least square geometric mean (LSGM) concentrations of BPA were significantly lower in Mexican Americans than in non-Hispanic blacks (p = 0.006) and non-Hispanic whites (p = 0.007); LSGM concentrations for non-Hispanic blacks and non-Hispanic whites were not statistically different (p = 0.21). Females had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had higher concentrations than adolescents (p < 0.001), who in turn had higher concentrations than adults (p = 0.003). LSGM concentrations were lowest for participants in the high household income category (> $45,000/year). Conclusions: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income. These first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities, including studies of exposure pathways, potential health effects, and risk assessment.
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“According to 2003–04 NHANES data, detectable levels of urinary BPA were found in over 92% of people 6 years of age or older sampled in USA [ 127 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [127]
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“Alarmingly, levels were highest among children [ 127 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [127]
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2000 CDC Growth Charts for the United States: methods and development.
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer‐Strawn, L. M., Flegal, K. M., Mei, Z., Wei, R. X., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2002) · PubMed · Cited by 3,716
Estimation of Average Concentration in the Presence of Nondetectable Values
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Human exposure to bisphenol A (BPA)
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In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
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Research works printed but not linked: 4
- CDC, 2003, National Health and Nutrition Examination Survey: Introduction to NHANES
- CDC, 2005, Third National Report on Human Exposure to Environmental Chemicals
- CDC, 2006, Survey Questionnaires, Examination Components and Laboratory Components 2003–2004
- CERHR (Center for the Evaluation of Risks to Human Reproduction), 2007, NTP–CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A—Interim Draft
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How Could Endocrine Disrupters Affect Human Health?
Darbre, P. D. (2015) · Endocrine Disruption and Human Health · doi:10.1016/b978-0-12-801139-3.00002-8 · Cited by 13
Metadata
- Authors
- Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Calafat, Antonia M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-10-24
- Volume
- 116
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC2199288
- OpenAlex
- W2067753015
- Cited by
- 1,743
- References
- 56
- Citations by year
- 2026: 45 · 2025: 58 · 2024: 65 · 2023: 68 · 2022: 84 · 2021: 107 · 2020: 105 · 2019: 101 · 2018: 139 · 2017: 113 · 2016: 124 · 2015: 119 · 2014: 147 · 2013: 131 · 2012: 93
- FWCI
- 38.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Environmental Health Perspectives (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- bisphenol A, urinary biomonitoring, human exposure assessment, polycarbonate plastics, nonionic surfactants, racial and ethnic differences, sex differences, age differences, household income, NHANES
- MeSH terms
- Bisphenol A Compounds, Adolescent, Adult, Benzhydryl Compounds, Child, Demography, Environmental Monitoring, Environmental Pollutants, Estrogens, Non-Steroidal, Female, Humans, Income, Male, Middle Aged, Nutrition Surveys, Phenols, United States
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