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Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Open accessAbstract
Background: Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States. Objectives: We aimed to assess exposure to BPA and tOP in the U.S. general population. Methods: We measured the total (free plus conjugated) urinary concentrations of BPA and tOP in 2,517 participants ≥ 6 years of age in the 2003–2004 National Health and Nutrition Examination Survey using automated solid-phase extraction coupled to isotope dilution–high-performance liquid chromatography–tandem mass spectrometry. Results: BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively. Least square geometric mean (LSGM) concentrations of BPA were significantly lower in Mexican Americans than in non-Hispanic blacks (p = 0.006) and non-Hispanic whites (p = 0.007); LSGM concentrations for non-Hispanic blacks and non-Hispanic whites were not statistically different (p = 0.21). Females had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had higher concentrations than adolescents (p < 0.001), who in turn had higher concentrations than adults (p = 0.003). LSGM concentrations were lowest for participants in the high household income category (> $45,000/year). Conclusions: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income. These first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities, including studies of exposure pathways, potential health effects, and risk assessment.
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“According to 2003–04 NHANES data, detectable levels of urinary BPA were found in over 92% of people 6 years of age or older sampled in USA [ 127 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [127]
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“Alarmingly, levels were highest among children [ 127 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [127]
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Cites
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426
2000 CDC Growth Charts for the United States: methods and development.
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer‐Strawn, L. M., Flegal, K. M., Mei, Z., Wei, R. X., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2002) · PubMed · Cited by 3,716
Estimation of Average Concentration in the Presence of Nondetectable Values
Hornung, R. W., & Reed, L. D. (1990) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1990.10389587 · Cited by 3,495
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Barr, D. B., Wilder, L. C., Caudill, S. P., Gonzalez, A. J., Needham, L. L., & Pirkle, J. L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7337 · Cited by 1,952
Self-citationShepard, T. H. (1981) · Teratology · doi:10.1002/tera.1420230118 · Cited by 1,298
Saal, F. S. V., & Hughes, C. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7713 · Cited by 1,174
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Environmental fate of alkylphenols and alkylphenol ethoxylates—a review
Ying, G., Williams, B., & Kookana, R. S. (2002) · Environment International · doi:10.1016/s0160-4120(02)00017-x · Cited by 1,088
Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration
Völkel, W., Colnot, T., Csanády, G. A., Filser, J. G., & Dekant, W. (2002) · Chemical Research in Toxicology · doi:10.1021/tx025548t · Cited by 1,039
Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population
Calafat, A. M., Kuklenyik, Z., Reidy, J. A., Caudill, S. P., Ekong, J., & Needham, L. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7534 · Cited by 1,031
Self-citationKang, J., Kondo, F., & Katayama, Y. (2006) · Toxicology · doi:10.1016/j.tox.2006.06.009 · Cited by 897
Exposure to bisphenol A advances puberty
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. (1999) · Nature · doi:10.1038/44517 · Cited by 820 · cited 1×
“…vaginal morphology and estrous cycles, disruption of sexual differentiation in the brain, and accelerated growth and puberty (Durando et al. 2007; Howdeshell et al. 1999; Kubo et al. 2003; Richter et al. 2007; Rubin et al. 2006; Schonfelder et al. 2002; Timms et al. 2005; vom Saal et al. 1998).”
BackgroundSaal, F. S. V., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757
Quality assurance of chemical measurements
Taylor, J. K., & Tranter, R. L. (1989) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)80373-6 · Cited by 690
Koch, H. M., Bolt, H. M., Preuss, R., & Angerer, J. (2005) · Archives of Toxicology · doi:10.1007/s00204-004-0642-4 · Cited by 557
Quality Assurance of Chemical Measurements
Lodge, J. P. (1988) · Atmospheric Environment (1967) · doi:10.1016/0004-6981(88)90464-7 · Cited by 521
Ye, X., Kuklenyik, Z., Needham, L. L., & Calafat, A. M. (2005) · Analytical Chemistry · doi:10.1021/ac050390d · Cited by 412
Self-citationTimms, B. G., Howdeshell, K. L., Barton, L., Bradley, S., Richter, C. A., & vom Saal, F. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502544102 · Cited by 394
Pottenger, L. H. (2000) · Toxicological Sciences · doi:10.1093/toxsci/54.1.3 · Cited by 381
Segner, H. E., Caroll, K., Fenske, M., Janssen, C., Maack, G., Pascoe, D. D., Schäfers, C., Vandenbergh, G., Watts, M. M., & Wenzel, A. (2003) · Ecotoxicology and Environmental Safety · doi:10.1016/s0147-6513(02)00039-8 · Cited by 379
Serum Bisphenol A Concentrations Showed Gender Differences, Possibly Linked to Androgen Levels
Takeuchi, T., & Tsutsumi, O. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6407 · Cited by 360
Teitelbaum, S. L., Britton, J. A., Calafat, A. M., Ye, X., Silva, M. J., Reidy, J. A., Galvez, M. P., Brenner, B. L., & Wolff, M. S. (2007) · Environmental Research · doi:10.1016/j.envres.2007.09.010 · Cited by 355
Self-citationPrenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats
Durando, M., Kass, L., Piva, J., Sonnenschein, C., Soto, A. M., Luque, E. H., & Muñoz‐de‐Toro, M. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9282 · Cited by 331
Bisphenol-A and chlorinated derivatives in adipose tissue of women
Fernández, M. F., Arrebola, J. P., Taoufiki, J., Navalón, A., Ballesteros, O., Pulgar, R., Vílchez, J. L., & Olea, N. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.007 · Cited by 314
Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R., & Aou, S. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(02)00251-1 · Cited by 311
Rubin, B. S., Lenkowski, J. R., Schaeberle, C. M., Vandenberg, L. N., Ronsheim, P. M., & Soto, A. M. (2006) · Endocrinology · doi:10.1210/en.2006-0189 · Cited by 311
Temporal Variability and Predictors of Urinary Bisphenol A Concentrations in Men and Women
Mahalingaiah, S., Meeker, J. D., Pearson, K. R., Calafat, A. M., Ye, X., Petrozza, J. C., & Hauser, R. B. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10605 · Cited by 305
Self-citationVölkel, W., Bittner, N., & Dekant, W. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.005454 · Cited by 270
Pilot Study of Urinary Biomarkers of Phytoestrogens, Phthalates, and Phenols in Girls
Wolff, M. S., Teitelbaum, S. L., Windham, G. C., Pinney, S. M., Britton, J. A., Chelimo, C., Godbold, J., Biro, F. M., Kushi, L. H., Pfeiffer, C. M., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9488 · Cited by 244
Self-citationKoch, H. M., & Angerer, J. (2006) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2006.11.008 · Cited by 167
Bisphenol A levels in human urine.
Matsumoto, A., Kunugita, N., Kitagawa, K., Isse, T., Oyama, T., Foureman, G. L., Morita, M., & Kawamoto, T. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5512 · Cited by 161
Ouchi, K., & Watanabe, S. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00547-0 · Cited by 144
Gender differences in the levels of bisphenol A metabolites in urine
Kim, Y., Kim, C.-S., Park, S., Han, S. Y., Pyo, M., & Yang, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.135 · Cited by 139
Goodman, J. E., McConnell, E. E., Sipes, I. G., Witorsch, R. J., Slayton, T. M., Yu, C. J., Lewis, A. S., & Rhomberg, L. R. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440600758317 · Cited by 131
Tan, B. L. L. (2003) · Talanta · doi:10.1016/s0039-9140(03)00281-9 · Cited by 130
In Utero Exposure to Low Doses of Bisphenol A Lead to Long-term Deleterious Effects in the Vagina
Schönfelder, G., Flick, B., Mayr, E., Talsness, C. E., Paul, M., & Chahoud, I. (2002) · Neoplasia · doi:10.1038/sj.neo.7900212 · Cited by 118
Biological Monitoring of Bisphenol A in a Korean Population
Yang, M., Kim, S., Lee, S.-M., Chang, S.-S., Kawamoto, T., Jang, J.-Y., & Ahn, Y. (2003) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-002-2124-0 · Cited by 103
Daily urinary excretion of bisphenol a
Arakawa, C., Fujimaki, K., Yoshinaga, J., Imai, H., Serizawa, S., & Shiraishi, H. (2004) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.9.22 · Cited by 96
Weight of the Evidence Evaluation of Low-Dose Reproductive and Developmental Effects of Bisphenol A
Gray, G. M., Cohen, J. T., Cunha, G. R., Hughes, C. L., McConnell, E. E., Rhomberg, L. R., Sipes, I. G., & Mattison, D. R. (2004) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807030490513883 · Cited by 92
Kawaguchi, M., Inoue, K., Sakui, N., Ito, R., Izumi, S., Makino, T., Okanouchi, N., & Nakazawa, H. (2003) · Journal of Chromatography B · doi:10.1016/j.jchromb.2003.10.021 · Cited by 89
Needham, L. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7490 · Cited by 89
Self-citationMiyamoto, K.-I., & Kotake, M. (2006) · PubMed · Cited by 67
Yang, M., Kim, S., Chang, S., Lee, I., & Kawamoto, T. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20230 · Cited by 66
Effects of maternal 4-tert-octylphenol exposure on the reproductive tract of male rats at adulthood
Aydoğan, M., & Barlas, N. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.01.004 · Cited by 65
The toxic effects of 4-tert-octylphenol on the reproductive system of male rats
Bian, Q., Qian, J., Xu, L., Chen, J., Song, L., & Wang, X. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.02.014 · Cited by 62
Pedersen, R. T., & Hill, E. M. (2002) · Environmental Science & Technology · doi:10.1021/es010249w · Cited by 57
Inoue, K., Kawaguchi, M., Okada, F., Takai, N., Yoshimura, Y., Horie, M., Izumi, S., Makino, T., & Nakazawa, H. (2003) · Analytica Chimica Acta · doi:10.1016/s0003-2670(03)00464-1 · Cited by 51
Analysis of environmental biomarkers in urine using an electrochemical detector
Liu, Z., Wolff, M. S., & Moline, J. M. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.02.005 · Cited by 49
Blake, C. A., Boockfor, F. R., Nair-Menon, J. U., Millette, C. F., RAYCHOUDHURY, S. S., & McCoy, G. L. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2003.09.003 · Cited by 48
Reproductive effects in male and female rats from neonatal exposure to p-octylphenol
Nagao, T., Yoshimura, S., Saito, Y., Nakagomi, M., Usumi, K., & Ono, H. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00173-3 · Cited by 45
Willoughby, K. N., Sarkar, A., Boyadjieva, N. I., & Sarkar, D. K. (2005) · Endocrine · doi:10.1385/endo:26:2:161 · Cited by 36
Pedersen, R. T., & Hill, E. M. (2000) · Xenobiotica · doi:10.1080/004982500433291 · Cited by 30
Pedersen, R. T., & Hill, E. M. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00205-2 · Cited by 28
Fujimaki, K., ARAKAWA, C., Yoshinaga, J., Watanabe, C., Serizawa, S., Imai, H., Shiraishi, H., & Mizumoto, Y. (2004) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.59.403 · Cited by 25
Ye, X., Bishop, A. M., Needham, L. L., & Calafat, A. M. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.015578 · Cited by 16
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- CDC, 2003, National Health and Nutrition Examination Survey: Introduction to NHANES
- CDC, 2005, Third National Report on Human Exposure to Environmental Chemicals
- CDC, 2006, Survey Questionnaires, Examination Components and Laboratory Components 2003–2004
- CERHR (Center for the Evaluation of Risks to Human Reproduction), 2007, NTP–CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A—Interim Draft
Cited by
Sorted by citations
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018
Lang, I. (2008) · JAMA · doi:10.1001/jama.300.11.1303 · Cited by 1,479
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
Rubin, B. S. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.05.002 · Cited by 1,478
Metadata
- Authors
- Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Calafat, Antonia M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-10-24
- Volume
- 116
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC2199288
- OpenAlex
- W2067753015
- Cited by
- 1,743
- References
- 56
- Citations by year
- 2026: 45 · 2025: 58 · 2024: 65 · 2023: 68 · 2022: 84 · 2021: 107 · 2020: 105 · 2019: 101 · 2018: 139 · 2017: 113 · 2016: 124 · 2015: 119 · 2014: 147 · 2013: 131 · 2012: 93
- FWCI
- 38.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Environmental Health Perspectives (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- bisphenol A, urinary biomonitoring, human exposure assessment, polycarbonate plastics, nonionic surfactants, racial and ethnic differences, sex differences, age differences, household income, NHANES
- MeSH terms
- Bisphenol A Compounds, Adolescent, Adult, Benzhydryl Compounds, Child, Demography, Environmental Monitoring, Environmental Pollutants, Estrogens, Non-Steroidal, Female, Humans, Income, Male, Middle Aged, Nutrition Surveys, Phenols, United States
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