The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Relationship between Urinary Phthalate and Bisphenol A Concentrations and Serum Thyroid Measures in U.S. Adults and Adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007–2008
Open accessAbstract
BACKGROUND: Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling. OBJECTIVE: We explored the cross-sectional relationship between urinary concentrations of metabolites of di(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and BPA with a panel of serum thyroid measures among a representative sample of U.S. adults and adolescents. METHODS: We analyzed data on urinary biomarkers of exposure to phthalates and BPA, serum thyroid measures, and important covariates from 1,346 adults (ages ≥ 20 years) and 329 adolescents (ages 12-19 years) from the National Health and Nutrition Examination Survey (NHANES) 2007-2008 using multivariable linear regression. RESULTS: Among adults, we observed significant inverse relationships between urinary DEHP metabolites and total thyroxine (T4), free T4, total triiodothyronine (T3), and thyroglobulin, and positive relationships with thyroid-stimulating hormone (TSH). The strongest and most consistent relationships involved total T4, where adjusted regression coefficients for quintiles of oxidative DEHP metabolites displayed monotonic dose-dependent decreases in total T4 (p-value for trend < 0.0001). Suggestive inverse relationships between urinary BPA and total T4 and TSH were also observed. Conversely, among adolescents, we observed significant positive relationships between DEHP metabolites and total T3. Mono(3-carboxypropyl) phthalate, a secondary metabolite of both DBP and di-n-octyl phthalate, was associated with several thyroid measures in both age groups, whereas other DBP metabolites were not associated with thyroid measures. CONCLUSIONS: These results support previous reports of associations between phthalates-and possibly BPA--and altered thyroid hormones. More detailed studies are needed to determine the temporal relationships and potential clinical and public health implications of these associations.
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Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
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Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
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Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist
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Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
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Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
Braun, J. M. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.186 · Cited by 930
Maternal lifestyle and environmental risk factors for autism spectrum disorders
Lyall, K., Schmidt, R. J., & Hertz-Picciotto, I. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt282 · Cited by 427
Critical review on the presence of phthalates in food and evidence of their biological impact
Giuliani, A., Zuccarini, M., Cichelli, A., Khan, H., & Reale, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165655 · Cited by 420
Metadata
- Authors
- Meeker, J. D., & Ferguson, K. K.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10
- Volume
- 119
- Issue
- 10
- Pages
- 1396-1402
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2041834425
- Cited by
- 337
- References
- 44
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Meeker, J. D., & Ferguson, K. K. (2011). Relationship between Urinary Phthalate and Bisphenol A Concentrations and Serum Thyroid Measures in U.S. Adults and Adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007–2008. Environmental Health Perspectives. https://doi.org/10.1289/ehp.1103582
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