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Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort
Open accessAbstract
Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects. Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting spot urine samples from the mothers during pregnancy (34 weeks on average) and from children between 3 and 4 years of age to estimate BPA exposure. We assessed child behavior between 3 and 5 years of age using the Child Behavior Checklist (CBCL) and used generalized linear models to test the association between BPA exposure and child behavior, adjusting for potential confounders. Results: The analysis was conducted on 198 children (87 boys and 111 girls). Among boys, high prenatal BPA exposure (highest quartile vs. the lowest three quartiles) was associated with significantly higher CBCL scores (more problems) on Emotionally Reactive [1.62 times greater; 95% confidence interval (CI): 1.13, 2.32] and Aggressive Behavior syndromes (1.29 times greater; 95% CI: 1.09, 1.53). Among girls, higher exposure was associated with lower scores on all syndromes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.99) and Aggressive Behavior (0.82 times as high; 95% CI: 0.70, 0.97). Conclusion: These results suggest that prenatal exposure to BPA may affect child behavior, and differently among boys and girls.
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“In a cohort of 198 children ages 3–5, high levels of maternal BPA were associated with altered emotional reactivity including increased aggressive behavior in boys [ 136 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [136]
In the citing paper
“Intriguingly, these boys at 3–5 years of age displayed increased aggressive behavior and their emotionally reactive symptom scores were 1.62 times higher compared with boys with low prenatal BPA concentrations [ 136 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [136]
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Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
Self-citationHinshaw, S. P. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.1.127 · Cited by 1,689
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S., & Soto, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0021 · Cited by 1,407
Exemplification of a Method for Scaling Life Events: The PERI Life Events Scale
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In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
In vitro molecular mechanisms of bisphenol A action.
Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885
Perera, F. P., Rauh, V., Tsai, W.-Y., Kinney, P., Camann, D., Barr, D., Bernert, T., Garfinkel, R., Tu, Y.-H., Diaz, D., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5742 · Cited by 625
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- National Toxicology Program, 2008, NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.
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Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018
Perera, F. P. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15010016 · Cited by 1,328
Self-citationEFSA Panel on Food Contact Materials, E. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.3978 · Cited by 1,075
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
Braun, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.186 · Cited by 965
The adverse health effects of bisphenol A and related toxicity mechanisms
Ya, M., Liu, H., Wu, J., Yuan, L., Wang, Y., Du, X., Wang, R., Marwa, P. W., Petlulu, P., Chen, X., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108575 · Cited by 855
Metadata
- Authors
- Perera, F., Vishnevetsky, J., Herbstman, J. B., Calafat, A. M., Xiong, W., Rauh, V., & Wang, S.
- Affiliations
- Columbia University (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Perera, Frederica
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-27
- Volume
- 120
- Issue
- 8
- Pages
- 1190-1194
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC3440080
- OpenAlex
- W2059905660
- Cited by
- 332
- References
- 40
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 20 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 55 · 2019: 24 · 2018: 24 · 2017: 35 · 2016: 22 · 2015: 38 · 2014: 17 · 2013: 26 · 2012: 3
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 2072 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- U.S. Environmental Protection Agency (P30 ES009089, RD832141, R827027, RD834509)
- New York Community Trust
- Educational Foundation of America
- Blanchette Hooker Rockefeller Fund
- Centers for Disease Control and Prevention (ES009089)
- National Institute of Environmental Health Sciences (P01ES009600, R00ES017051, R01ES008977, P30ES009089)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- bisphenol A, prenatal exposure, endocrine disruptors, child behavior, sex differences, developmental neurotoxicity, aggression, emotional reactivity, urinary BPA, inner-city children, African American women, Dominican women
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Child Behavior, Child, Preschool, Female, Hispanic or Latino, Humans, Male, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Urban Population, Cohort Studies
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