The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort
Open accessAbstract
Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects. Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting spot urine samples from the mothers during pregnancy (34 weeks on average) and from children between 3 and 4 years of age to estimate BPA exposure. We assessed child behavior between 3 and 5 years of age using the Child Behavior Checklist (CBCL) and used generalized linear models to test the association between BPA exposure and child behavior, adjusting for potential confounders. Results: The analysis was conducted on 198 children (87 boys and 111 girls). Among boys, high prenatal BPA exposure (highest quartile vs. the lowest three quartiles) was associated with significantly higher CBCL scores (more problems) on Emotionally Reactive [1.62 times greater; 95% confidence interval (CI): 1.13, 2.32] and Aggressive Behavior syndromes (1.29 times greater; 95% CI: 1.09, 1.53). Among girls, higher exposure was associated with lower scores on all syndromes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.99) and Aggressive Behavior (0.82 times as high; 95% CI: 0.70, 0.97). Conclusion: These results suggest that prenatal exposure to BPA may affect child behavior, and differently among boys and girls.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a cohort of 198 children ages 3–5, high levels of maternal BPA were associated with altered emotional reactivity including increased aggressive behavior in boys [ 136 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [136]
In the citing paper
“Intriguingly, these boys at 3–5 years of age displayed increased aggressive behavior and their emotionally reactive symptom scores were 1.62 times higher compared with boys with low prenatal BPA concentrations [ 136 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [136]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Human exposure to bisphenol A (BPA)
Vandenberg, L. N., Hauser, R. B., Marcus, M., Olea, N., & Welshons, W. V. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.010 · Cited by 2,984
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
Self-citationHinshaw, S. P. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.1.127 · Cited by 1,689
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S., & Soto, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0021 · Cited by 1,407
Exemplification of a Method for Scaling Life Events: The PERI Life Events Scale
Dohrenwend, B. S., Askenasy, A. R., Krasnoff, L., & Dohrenwend, B. P. (1978) · Journal of Health and Social Behavior · doi:10.2307/2136536 · Cited by 1,211
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
In vitro molecular mechanisms of bisphenol A action.
Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885
Perera, F. P., Rauh, V., Tsai, W.-Y., Kinney, P., Camann, D., Barr, D., Bernert, T., Garfinkel, R., Tu, Y.-H., Diaz, D., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5742 · Cited by 625
Self-citationImpact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children
Braun, J. M., Kalkbrenner, A. E., Calafat, A. M., Yolton, K. A., Ye, X., Dietrich, K. N., & Lanphear, B. P. (2011) · PEDIATRICS · doi:10.1542/peds.2011-1335 · Cited by 588
Self-citationNTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Hayward, S. W., Lees, P. S. J., Mcintyre, B., Portier, K. M., Schnorr, T. M., Selevan, S. G., et al. (2008) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20147 · Cited by 514
Zoeller, R. T., Bansal, R., & Parris, C. (2004) · Endocrinology · doi:10.1210/en.2004-1018 · Cited by 512
Prenatal bisphenol A exposure and early childhood behavior.
Braun, J. M., Yolton, K., Dietrich, K. N., Hornung, R., Ye, X., Calafat, A. M., & Lanphear, B. P. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900979 · Cited by 481
Self-citationTemporal Variability of Urinary Phthalate Metabolite Levels in Men of Reproductive Age
Hauser, R. B., Meeker, J. D., Park, S., Silva, M. J., & Calafat, A. M. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7212 · Cited by 475
Self-citationEndocrine disruptors and childhood social impairment
Miodovnik, A., Engel, S. M., Zhu, C., Ye, X., Soorya, L. V., Silva, M. J., Calafat, A. M., & Wolff, M. S. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2010.12.009 · Cited by 423
Self-citationYe, X., Kuklenyik, Z., Needham, L. L., & Calafat, A. M. (2005) · Analytical Chemistry · doi:10.1021/ac050390d · Cited by 412
Self-citationTeitelbaum, S. L., Britton, J. A., Calafat, A. M., Ye, X., Silva, M. J., Reidy, J. A., Galvez, M. P., Brenner, B. L., & Wolff, M. S. (2007) · Environmental Research · doi:10.1016/j.envres.2007.09.010 · Cited by 355
Self-citationVariability and predictors of urinary bisphenol A concentrations during pregnancy
Braun, J. M., Kalkbrenner, A. E., Calafat, A. M., Bernert, J. T., Ye, X., Silva, M. J., Barr, D. B., Sathyanarayana, S., & Lanphear, B. P. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002366 · Cited by 352
Self-citationTemporal Variability and Predictors of Urinary Bisphenol A Concentrations in Men and Women
Mahalingaiah, S., Meeker, J. D., Pearson, K. R., Calafat, A. M., Ye, X., Petrozza, J. C., & Hauser, R. B. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10605 · Cited by 305
Self-citationYe, X., Wong, L.-Y., Bishop, A. M., & Calafat, A. M. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002701 · Cited by 299
Self-citationEffects of developmental exposure to bisphenol A on brain and behavior in mice
Palanza, P., Gioiosa, L., Saal, F. S. V., & Parmigiani, S. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.023 · Cited by 283
Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure
Taylor, J. A., Saal, F. S. V., Welshons, W. V., Drury, B. E., Rottinghaus, G. E., Hunt, P. A., Toutain, P., Laffont, C. M., & VandeVoort, C. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002514 · Cited by 277
Effect of anxiety reduction on children's school performance and social adjustment.
Wood, J. J. (2006) · Developmental Psychology · doi:10.1037/0012-1649.42.2.345 · Cited by 241
The Home Inventory: Review and Reflections
Bradley, R. H. (1994) · Advances in child development and behavior · doi:10.1016/s0065-2407(08)60054-3 · Cited by 218
Tian, Y., Baek, J., Lee, S., & Jang, C. (2010) · Synapse · doi:10.1002/syn.20746 · Cited by 197
Perinatal Exposure to the Estrogenic Pollutant Bisphenol A Affects Behavior in Male and Female Rats
Farabollini, F. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00136-7 · Cited by 186
Naciff, J. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.184 · Cited by 185
Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice
Ryan, B. C., & Vandenbergh, J. G. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.01.007 · Cited by 180
Poimenova, A., Markaki, E., Rahiotis, C., & Kitraki, E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.051 · Cited by 174
Kawai, K., Nozaki, T., Hiroaki, N., Aou, S., Takii, M., & Kubo, C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5440 · Cited by 174
Gross, D. A., Fogg, L., Young, M. A., Ridge, A., Cowell, J. M., Richardson, R., & Sivan, A. B. (2006) · Psychological Assessment · doi:10.1037/1040-3590.18.3.313 · Cited by 168
Prenatal Di(2-ethylhexyl)Phthalate Exposure and Length of Gestation Among an Inner-City Cohort
Whyatt, R. M., Adibi, J. J., Calafat, A. M., Camann, D., Rauh, V., Bhat, H. K., Perera, F. P., Andrews, H., Just, A. C., Hoepner, L., et al. (2009) · PEDIATRICS · doi:10.1542/peds.2009-0325 · Cited by 142
Self-citationPharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
Doerge, D. R., Twaddle, N. C., Woodling, K. A., & Fisher, J. W. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.07.009 · Cited by 109
Miyagawa, K., Narita, M., Narita, M., Akama, H., & Suzuki, T. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.088 · Cited by 108
Nakagami, A., Negishi, T., Kawasaki, K., Imai, N., Nishida, Y., Ihara, T., Kuroda, Y., Yoshikawa, Y., & Koyama, T. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.005 · Cited by 63
Xu, X.-H., Wang, Y.-M., Zhang, J., Luo, Q.-Q., Ye, Y.-P., & Ruan, Q. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.18 · Cited by 53
Nakamura, K., Itoh, K., Yoshimoto, K., Sugimoto, T., & Fushiki, S. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.021 · Cited by 53
Mizuo, K., Narita, M., Miyagawa, K., Narita, M., Okuno, E., & Suzuki, T. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.027 · Cited by 43
Myers, C. L., Bour, J. L., Sidebottom, K. J., Murphy, S., & Hakman, M. (2010) · Psychology in the Schools · doi:10.1002/pits.20465 · Cited by 25
Research works printed but not linked: 1
- National Toxicology Program, 2008, NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.
Cited by
Sorted by citations
Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018
Perera, F. P. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15010016 · Cited by 1,328
Self-citationEFSA Panel on Food Contact Materials, E. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.3978 · Cited by 1,075
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
Braun, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.186 · Cited by 965
The adverse health effects of bisphenol A and related toxicity mechanisms
Ya, M., Liu, H., Wu, J., Yuan, L., Wang, Y., Du, X., Wang, R., Marwa, P. W., Petlulu, P., Chen, X., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108575 · Cited by 855
Metadata
- Authors
- Perera, F., Vishnevetsky, J., Herbstman, J. B., Calafat, A. M., Xiong, W., Rauh, V., & Wang, S.
- Affiliations
- Columbia University (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Perera, Frederica
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-27
- Volume
- 120
- Issue
- 8
- Pages
- 1190-1194
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC3440080
- OpenAlex
- W2059905660
- Cited by
- 332
- References
- 40
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 20 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 55 · 2019: 24 · 2018: 24 · 2017: 35 · 2016: 22 · 2015: 38 · 2014: 17 · 2013: 26 · 2012: 3
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 2072 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- U.S. Environmental Protection Agency (P30 ES009089, RD832141, R827027, RD834509)
- New York Community Trust
- Educational Foundation of America
- Blanchette Hooker Rockefeller Fund
- Centers for Disease Control and Prevention (ES009089)
- National Institute of Environmental Health Sciences (P01ES009600, R00ES017051, R01ES008977, P30ES009089)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- bisphenol A, prenatal exposure, endocrine disruptors, child behavior, sex differences, developmental neurotoxicity, aggression, emotional reactivity, urinary BPA, inner-city children, African American women, Dominican women
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Child Behavior, Child, Preschool, Female, Hispanic or Latino, Humans, Male, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Urban Population, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
