The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic Inuit
Open accessAbstract
Background: Persistent organic pollutants (POPs) may influence epigenetic mechanisms; therefore, they could affect chromosomal stability and gene expression. DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highest reported POP levels worldwide. Objective: Our aim in this study was to evaluate the relationship between plasma POPs concentrations and global DNA methylation (percent 5-methylcytosine) in DNA extracted from blood samples from 70 Greenlandic Inuit. Blood samples were collected under the Arctic Monitoring and Assessment Program and previously analyzed for a battery of POPs. Methods: We used pyrosequencing to estimate global DNA methylation via Alu and LINE-1 assays of bisulfite-treated DNA. We investigated correlations between plasma POP concentrations and global DNA methylation via correlation coefficients and linear regression analyses. Results: We found inverse correlations between percents methylcytosine and many of the POP concentrations measured. Linear regressions, adjusting for age and cigarette smoking, showed statistically significant inverse linear relationships mainly for the Alu assay for p,p′-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; β = −0.26), p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene; β = −0.38], β-hexachlorocyclohexane (β = −0.48), oxychlordane (β = −0.32), α-chlordane (β = −0.75), mirex (β = −0.27), sum of polychlorinated biphenyls (β = −0.56), and sum of all POPs (β = −0.48). Linear regressions for the LINE-1 assay showed β estimates of similar magnitudes to those using the Alu assay, however, none was statistically significant. Conclusions: This is the first study to investigate environmental exposure to POPs and DNA methylation levels in a human population. Global methylation levels were inversely associated with blood plasma levels for several POPs and merit further investigation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A similar trend was observed in a second population of healthy Koreans for NDL PCB 153, 183, and 187 [ 37 ] and in a population of Greenlandic Inuits [ 38 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [38]
In the citing paper
“There is evidence to suggest that the DL and NDL PCBs have opposing actions on DNA methylation, with DL PCBs shifting the balance toward DNA hypermethylation, as was observed in the Sweden study [ 39 ], and NDL PCBs favoring DNA hypomethylation as observed in the Korean and Inuit studies [ 36 , 38 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Chang, H., Anway, M. D., Rekow, S. S., & Skinner, M. K. (2006) · Endocrinology · doi:10.1210/en.2006-0987 · Cited by 148
RetractedThe fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
Yang, A. S. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh032 · Cited by 1,033
DNA hypomethylation and human diseases
Wilson, A. S., Power, B. E., & Molloy, P. L. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.007 · Cited by 804
Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene
Bollati, V., Baccarelli, A., Hou, L., Bonzini, M., Fustinoni, S., Cavallo, D. M., Byun, H., Jiang, J., Marinelli, B., Pesatori, A. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2995 · Cited by 612
Self-citationEndocrine Disruptor Vinclozolin Induced Epigenetic Transgenerational Adult-Onset Disease
Anway, M. D., Leathers, C. W., & Skinner, M. K. (2006) · Endocrinology · doi:10.1210/en.2006-0640 · Cited by 569
The role of folic acid and Vitamin B12 in genomic stability of human cells
Fenech, M. F. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00079-3 · Cited by 470
Epigenetic Transgenerational Actions of Endocrine Disruptors
Anway, M. D., & Skinner, M. K. (2006) · Endocrinology · doi:10.1210/en.2005-1058 · Cited by 455
New Modes of Action for Endocrine-Disrupting Chemicals
Tabb, M. M., & Blumberg, B. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0513 · Cited by 452
Gonzalgo, M. L., & Jones, P. A. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.12.2529 · Cited by 367
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Danish Environmental Protection Agency, 1997, AMAP Greenland 1994–1996. Environmental Project No. 356
- Deutch, 2000, High human plasma levels of organochlorine compounds in Greenland, Danish Medical Bulletin, 47, 132
- Van Oostdam, 2003, Biological monitoring: human tissue levels of environmental contaminants, 31
Cited by
Sorted by citations
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Mostafalou, S., & Abdollahi, M. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.01.025 · Cited by 1,333
Jayaraj, R., Megha, P., & Sreedev, P. (2016) · Interdisciplinary Toxicology · doi:10.1515/intox-2016-0012 · Cited by 1,171
Epigenetics and environmental chemicals
Baccarelli, A., & Bollati, V. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32832925cc · Cited by 967
Self-citationHazardous effects of chemical pesticides on human health–Cancer and other associated disorders
Sabarwal, A., Kumar, K., & Singh, R. P. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.08.018 · Cited by 701
Chemical pollution: A growing peril and potential catastrophic risk to humanity
Naidu, R., Biswas, B., Willett, I. R., Cribb, J., Singh, B. K., Nathanail, C. P., Coulon, F., Semple, K. T., Jones, K. C., Barclay, A., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106616 · Cited by 698
Metadata
- Authors
- Rusiecki, J. A., Baccarelli, A., Bollati, V., Tarantini, L., Moore, L. E., & Bonefeld-Jorgensen, E. C.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- University of Milan (IT)
- National Institutes of Health (US)
- University of Aarhus, Unit of Cellular and Molecular Toxicology, Centre of Arctic Environmental Medicine, Institute of Public Health, University of Aarhus, Aarhus, Denmark
- Corresponding author
- Rusiecki, Jennifer A.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-16
- Volume
- 116
- Issue
- 11
- Pages
- 1547-1552
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC2592276
- OpenAlex
- W2087008478
- Cited by
- 352
- References
- 51
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 15 · 2021: 24 · 2020: 21 · 2019: 24 · 2018: 19 · 2017: 23 · 2016: 26 · 2015: 30 · 2014: 23 · 2013: 32 · 2012: 34
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 3453 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Uniformed Services University of the Health Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- persistent organic pollutants, global DNA methylation, DNA hypomethylation, Greenlandic Inuit, p,p'-DDE, p,p'-DDT, polychlorinated biphenyls, organochlorine pesticides, Alu elements, LINE-1 elements, epigenetics, environmental exposure, plasma concentration
- MeSH terms
- Adult, Aged, DNA, Environmental Pollutants, Inuit, Female, Greenland, Humans, Male, Middle Aged, Organic Chemicals, Pesticides, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
