The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding
Open accessAbstract
OBJECTIVE: In this study we reviewed the half-life data in the literature for the 29 dioxin, furan, and polychlorinated biphenyl congeners named in the World Health Organization toxic equivalency factor scheme, with the aim of providing a reference value for the half-life of each congener in the human body and a method of half-life estimation that accounts for an individual's personal characteristics. DATA SOURCES AND EXTRACTION: We compared data from >30 studies containing congener-specific elimination rates. Half-life data were extracted and compiled into a summary table. We then created a subset of these data based on defined exclusionary criteria. DATA SYNTHESIS: We defined values for each congener that approximate the half-life in an infant and in an adult. A linear interpolation of these values was used to examine the relationship between half-life and age, percent body fat, and absolute body fat. We developed predictive equations based on these relationships and adjustments for individual characteristics. CONCLUSIONS: The half-life of dioxins in the body can be predicted using a linear relationship with age adjusted for body fat, smoking, and breast-feeding. Data suggest an alternative method based on a linear relationship between half-life and total body fat, but this approach requires further testing and validation with individual measurements.
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Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl055 · Cited by 3,785
Body mass index as a measure of body fatness: age- and sex-specific prediction formulas
Deurenberg, P., Weststrate, J. A., & Seidell, J. C. (1991) · British Journal of Nutrition · doi:10.1079/bjn19910073 · Cited by 1,358
Drug Interactions with Tobacco Smoking: An Update
Zevin, S., & Benowitz, N. L. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199936060-00004 · Cited by 692
Schecter, A., Birnbaum, L., Ryan, J. J., & Constable, J. D. (2006) · Environmental Research · doi:10.1016/j.envres.2005.12.003 · Cited by 561
PCBs: Recent Advances in Environmental Toxicology and Health Effects
Burgin, D. E. (2002) · International Journal of Toxicology · doi:10.1177/109158180202100610 · Cited by 366
ELIMINATION OF POLYCHLORINATED DIBENZO-p-DIOXINS AND DIBENZOFURANS IN OCCUPATIONALLY EXPOSED PERSONS
Flesch-Janys, D. (1996) · Journal of Toxicology and Environmental Health · doi:10.1080/009841096161708 · Cited by 226
PCDD/F and dioxin-like PCB in human blood and milk from German mothers
Wittsiepe, J., Fürst, P., Schrey, P., Lemm, F., Kraft, M., Eberwein, G., Winneke, G., & Wilhelm, M. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2006.05.118 · Cited by 198
Clewell, H. J., Gentry, P. R., Covington, T. R., Sarangapani, R., & Teeguarden, J. G. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh109 · Cited by 193
Chemical contaminants in breast milk and their impacts on children's health: an overview.
Landrigan, P. J., Sonawane, B., Mattison, D., McCally, M., & Garg, A. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.021100313 · Cited by 193
Kreuzer, P. E., Csanády, G. A., Baur, C., Kessler, W., Päpke, O., Greim, H., & Filser, J. G. (1997) · Archives of Toxicology · doi:10.1007/s002040050402 · Cited by 173
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus
Dickerson, S. M., Cunningham, S. L., & Gore, A. C. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.01.012 · Cited by 95
Güil-Oumrait, N., Valvi, D., Garcia-Esteban, R., Guxens, M., Sunyer, J., Torrent, M., Casas, M., & Vrijheid, M. (2021) · Environment International · doi:10.1016/j.envint.2021.106469 · Cited by 57
Itoh, H., Iwasaki, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Yoshida, T., Yokoyama, K., & Tsugane, S. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.05.035 · Cited by 53
Polychlorinated biphenyl (PCB) half-lives in humans: A systematic review
Idowu, I. G., Megson, D., Tiktak, G., Dereviankin, M., & Sandau, C. D. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140359 · Cited by 42
Metadata
- Authors
- Milbrath, M. O., Wenger, Y., Chang, C.-W., Emond, C., Garabrant, D., Gillespie, B. W., & Jolliet, O.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-03
- Volume
- 117
- Issue
- 3
- Pages
- 417-425
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2062470398
- Cited by
- 279
- References
- 35
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Milbrath, M. O., Wenger, Y., Chang, C.-W., Emond, C., Garabrant, D., Gillespie, B. W., & Jolliet, O. (2009). Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding. Environmental Health Perspectives. https://doi.org/10.1289/ehp.11781
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