The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenic in Utero
Open accessAbstract
BACKGROUND: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations, specifically by altering patterns of DNA methylation. OBJECTIVES: In this study we aimed to identify differences in DNA methylation in cord blood samples of infants with in utero, low-level arsenic exposure. METHODS: DNA methylation of cord-blood derived DNA from 134 infants involved in a prospective birth cohort in New Hampshire was profiled using the Illumina Infinium Methylation450K array. In utero arsenic exposure was estimated using maternal urine samples collected at 24-28 weeks gestation. We used a novel cell mixture deconvolution methodology for examining the association between inferred white blood cell mixtures in infant cord blood and in utero arsenic exposure; we also examined the association between methylation at individual CpG loci and arsenic exposure levels. RESULTS: We found an association between urinary inorganic arsenic concentration and the estimated proportion of CD8+ T lymphocytes (1.18; 95% CI: 0.12, 2.23). Among the top 100 CpG loci with the lowest p-values based on their association with urinary arsenic levels, there was a statistically significant enrichment of these loci in CpG islands (p = 0.009). Of those in CpG islands (n = 44), most (75%) exhibited higher methylation levels in the highest exposed group compared with the lowest exposed group. Also, several CpG loci exhibited a linear dose-dependent relationship between methylation and arsenic exposure. CONCLUSIONS: Our findings suggest that in utero exposure to low levels of arsenic may affect the epigenome. Long-term follow-up is planned to determine whether the observed changes are associated with health outcomes.
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Adjusting batch effects in microarray expression data using empirical Bayes methods
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DNA methylation arrays as surrogate measures of cell mixture distribution
Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-86 · Cited by 3,175
Self-citationDu, P., Zhang, X., Huang, C.-C., Jafari, N., Kibbe, W. A., Hou, L., & Lin, S. M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-587 · Cited by 2,136
Naujokas, M. F., Anderson, B., Ahsan, H., Aposhian, H. V., Graziano, J. H., Thompson, C., & Suk, W. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205875 · Cited by 1,372
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Koestler, D. C., Christensen, B. C., Karagas, M. R., Marsit, C. J., Langevin, S. M., Kelsey, K. T., Wiencke, J. K., & Houseman, E. A. (2013) · Epigenetics · doi:10.4161/epi.25430 · Cited by 251
Self-citationDu, J., Zhou, N., Liu, H., Jiang, F., Wang, Y., Hu, C., Qi, H., Zhong, C., Wang, X., & Li, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035957 · Cited by 65
Cited by
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Cosselman, K. E., Navas-Acien, A., & Kaufman, J. D. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.152 · Cited by 613
Tyler, C. R., & Allan, A. M. (2014) · Current Environmental Health Reports · doi:10.1007/s40572-014-0012-1 · Cited by 537
Influence of environmental exposure on human epigenetic regulation
Marsit, C. J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.106971 · Cited by 253
Self-citationKoestler, D. C., Christensen, B. C., Karagas, M. R., Marsit, C. J., Langevin, S. M., Kelsey, K. T., Wiencke, J. K., & Houseman, E. A. (2013) · Epigenetics · doi:10.4161/epi.25430 · Cited by 251
Self-citationThe role of environmental factors in modulating immune responses in early life
MacGillivray, D. M., & Kollmann, T. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00434 · Cited by 219
Metadata
- Authors
- Koestler, D. C., Avissar-Whiting, M., Houseman, E. A., Karagas, M. R., & Marsit, C. J.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08
- Volume
- 121
- Issue
- 8
- Pages
- 971-977
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2157834732
- Cited by
- 178
- References
- 8
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Koestler, D. C., Avissar-Whiting, M., Houseman, E. A., Karagas, M. R., & Marsit, C. J. (2013). Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenic in Utero. Environmental Health Perspectives. https://doi.org/10.1289/ehp.1205925
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