Cited by 555Effects and risks of endocrine disrupting chemicalsReproductive Biology and FertilityEstrogen and related hormone effects

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

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Peretz, Jackye, Vrooman, Lisa, Ricke, William A., Hunt, Patricia A., Ehrlich, Shelley, Hauser, Russ, Padmanabhan, Vasantha, Taylor, Hugh S. +3 more·2014·Environmental Health Perspectives

Abstract

Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant. Citation: Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. 2014. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786; http://dx.doi.org/10.1289/ehp.1307728

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Authors
Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., & Flaws, J. A.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • Washington State University (US)
  • University of Wisconsin–Madison (US)
  • Cincinnati Children's Hospital Medical Center (US)
  • Harvard University (US)
  • University of Michigan (US)
  • Yale University (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • University of California, Davis (US)
Corresponding author
Flaws, Jodi A.
Venue
Environmental Health Perspectives
Published
2014-06-04
Volume
122
Issue
8
Pages
775-786
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
OpenAlex
W2020338693
Cited by
555
References
140
Citations by year
2026: 28 · 2025: 32 · 2024: 34 · 2023: 51 · 2022: 38 · 2021: 46 · 2020: 51 · 2019: 43 · 2018: 56 · 2017: 43 · 2016: 68 · 2015: 56 · 2014: 7
FWCI
6.00
Type
journal article
Language
en
Open access
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • Europe PMC (PubMed Central) (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • eScholarship (California Digital Library) (submittedVersion, public-domain)
Funders
  • National Institutes of Health (P51OD011107)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
  • National Institute of Environmental Health Sciences (R01ES16541, RC2ES18764, R01ES009718, R01ES016770, R01ES9718, R01ES016541, R01ES019178, P20ES018163, R01ES16770, P01ES022844, R01ES017005, R01ES013527, R01 ES13527, P01ES022848, R01ES17005, RC2ES018764, P30ES023515, P30ES017885)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
bisphenol A, reproductive toxicity, endocrine disruptors, female reproduction, male reproduction, ovarian toxicity, uterine toxicity, testicular toxicity, meiosis, steroidogenesis, oocyte quality, in vitro fertilization, endometrial proliferation, endometrial receptivity, implantation failure, birth outcomes, hyperandrogenism, sexual dysfunction, mechanism of action
MeSH terms
Bisphenol A Compounds, Animals, Benzhydryl Compounds, Female, Humans, Male, Embryo Implantation, Phenols, Pregnancy, Reproduction

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