Cited by 555Effects and risks of endocrine disrupting chemicalsReproductive Biology and FertilityEstrogen and related hormone effects

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Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

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Peretz, Jackye, Vrooman, Lisa, Ricke, William A., Hunt, Patricia A., Ehrlich, Shelley, Hauser, Russ, Padmanabhan, Vasantha, Taylor, Hugh S., Swan, Shanna H., VandeVoort, Catherine A., Flaws, Jodi A.·2014·Environmental Health Perspectives

DOI 10.1289/ehp.1307728PMC PMC4123031

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Abstract

Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction. Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action. Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction. Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development. Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant. Citation: Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. 2014. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786; http://dx.doi.org/10.1289/ehp.1307728

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Authors: Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., & Flaws, J. A.
Affiliations: University of Illinois Urbana-Champaign (US)
Washington State University (US)
University of Wisconsin–Madison (US)
Cincinnati Children's Hospital Medical Center (US)
Harvard University (US)
University of Michigan (US)
Yale University (US)
Icahn School of Medicine at Mount Sinai (US)
University of California, Davis (US)
Corresponding author: Flaws, Jodi A.
ORCID: Peretz, Jackye
Vrooman, Lisa
Ricke, William A.
Hunt, Patricia A.
Ehrlich, Shelley
Hauser, Russ
Padmanabhan, Vasantha
Taylor, Hugh S.
Swan, Shanna H.
VandeVoort, Catherine A.
Flaws, Jodi A.
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2014-06-04
Volume: 122
Issue: 8
Pages: 775-786
ISSN: 0091-6765 (ISSN-L)
1552-9924
DOI: 10.1289/ehp.1307728
PMC: PMC4123031
OpenAlex: W2020338693
Cited by: 555
References: 140
Citations by year: 2026: 28 · 2025: 32 · 2024: 34 · 2023: 51 · 2022: 38 · 2021: 46 · 2020: 51 · 2019: 43 · 2018: 56 · 2017: 43 · 2016: 68 · 2015: 56 · 2014: 7
FWCI: 6.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: public-domain
creativecommons.org/licenses/by/4.0/ (vor, 1304 d)
Locations: Environmental Health Perspectives (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion, public-domain)
Funders: National Institutes of Health (P51OD011107)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
National Institute of Environmental Health Sciences (R01ES16541, RC2ES18764, R01ES009718, R01ES016770, R01ES9718, R01ES016541, R01ES019178, P20ES018163, R01ES16770, P01ES022844, R01ES017005, R01ES013527, R01 ES13527, P01ES022848, R01ES17005, RC2ES018764, P30ES023515, P30ES017885)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: bisphenol A, reproductive toxicity, endocrine disruptors, female reproduction, male reproduction, ovarian toxicity, uterine toxicity, testicular toxicity, meiosis, steroidogenesis, oocyte quality, in vitro fertilization, endometrial proliferation, endometrial receptivity, implantation failure, birth outcomes, hyperandrogenism, sexual dysfunction, mechanism of action
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Female, Humans, Male, Embryo Implantation, Phenols, Pregnancy, Reproduction

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Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

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