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Cited by 891

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Workgroup Report: Drinking-Water Nitrate and Health—Recent Findings and Research Needs

Open access
Ward, Mary H., deKok, Theo M., Levallois, Patrick, Brender, Jean, Gulis, Gabriel, Nolan, Bernard T., VanDerslice, James·2005·Environmental Health Perspectives
DOI 10.1289/ehp.8043
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Abstract

Human alteration of the nitrogen cycle has resulted in steadily accumulating nitrate in our water resources. The U.S. maximum contaminant level and World Health Organization guidelines for nitrate in drinking water were promulgated to protect infants from developing methemoglobinemia, an acute condition. Some scientists have recently suggested that the regulatory limit for nitrate is overly conservative; however, they have not thoroughly considered chronic health outcomes. In August 2004, a symposium on drinking-water nitrate and health was held at the International Society for Environmental Epidemiology meeting to evaluate nitrate exposures and associated health effects in relation to the current regulatory limit. The contribution of drinking-water nitrate toward endogenous formation of N-nitroso compounds was evaluated with a focus toward identifying subpopulations with increased rates of nitrosation. Adverse health effects may be the result of a complex interaction of the amount of nitrate ingested, the concomitant ingestion of nitrosation cofactors and precursors, and specific medical conditions that increase nitrosation. Workshop participants concluded that more experimental studies are needed and that a particularly fruitful approach may be to conduct epidemiologic studies among susceptible subgroups with increased endogenous nitrosation. The few epidemiologic studies that have evaluated intake of nitrosation precursors and/or nitrosation inhibitors have observed elevated risks for colon cancer and neural tube defects associated with drinking-water nitrate concentrations below the regulatory limit. The role of drinking-water nitrate exposure as a risk factor for specific cancers, reproductive outcomes, and other chronic health effects must be studied more thoroughly before changes to the regulatory level for nitrate in drinking water can be considered.

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Metadata

Authors
Ward, M. H., deKok, T. M., Levallois, P., Brender, J., Gulis, G., Nolan, B. T., & VanDerslice, J.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2005-11
Volume
113
Issue
11
Pages
1607-1614
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.8043
OpenAlex
W2052871899
Cited by
891
References
86
FWCI
13.19
Type
journal article
Language
en
Open access
gold

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