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Fine Particulate Air Pollution and Mortality in Nine California Counties: Results from CALFINE
Open accessAbstract
Many epidemiologic studies provide evidence of an association between daily counts of mortality and ambient particulate matter<10 microm in diameter (PM10). Relatively few studies, however, have investigated the relationship of mortality with fine particles [PM<2.5 microm in diameter (PM2.5)], especially in a multicity setting. We examined associations between PM2.5 and daily mortality in nine heavily populated California counties using data from 1999 through 2002. We considered daily counts of all-cause mortality and several cause-specific subcategories (respiratory, cardiovascular, ischemic heart disease, and diabetes). We also examined these associations among several subpopulations, including the elderly (>65 years of age), males, females, non-high school graduates, whites, and Hispanics. We used Poisson multiple regression models incorporating natural or penalized splines to control for covariates that could affect daily counts of mortality, including time, seasonality, temperature, humidity, and day of the week. We used meta-analyses using random-effects models to pool the observations in all nine counties. The analysis revealed associations of PM2.5 levels with several mortality categories. Specifically, a 10-microg/m3 change in 2-day average PM2.5 concentration corresponded to a 0.6% (95% confidence interval, 0.2-1.0%) increase in all-cause mortality, with similar or greater effect estimates for several other subpopulations and mortality subcategories, including respiratory disease, cardiovascular disease, diabetes, age>65 years, females, deaths out of the hospital, and non-high school graduates. Results were generally insensitive to model specification and the type of spline model used. This analysis adds to the growing body of evidence linking PM2.5 with daily mortality.
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“Previous work on this issue has focused primarily on PM10, although strong mortality associations have been demonstrated for the fine fraction (Kan et al. 2007; Ostro et al. 2006; Schwartz et al. 1996).”
From Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies (2007) · cites this paper as Ostro et al. 2006
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“Our study confirmed previous findings that fine particle was more strongly associated with cardio-respiratory mortality than with all-cause mortality risk (Ostro et al. 2006; Stolzel et al. 2006; Wichmann et al. 2000).”
From Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China (2007) · cites this paper as Ostro et al. 2006
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“…time, data on fine particles have been collected in many parts of the United States, and evidence has accumulated sug gesting significant effects of fine particles on both mortality (Ostro et al. 2006; Zanobetti and Schwartz 2009) and hospital admissions (Bell et al. 2008; Dominici et al. 2006).”
Are Particulate Matter Exposures Associated with Risk of Type 2 Diabetes?
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“Finally, diabetesrelated mortality has been associated with PM and other ambient air pol lutant exposures (Kan et al. 2004; Maynard et al. 2007; Ostro et al. 2006).”
BackgroundMortality Risk Associated with Short-Term Exposure to Traffic Particles and Sulfates
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ResultEnvironmental factors and developmental outcomes in the lung
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BackgroundInfluentialCharacterizing Temperature and Mortality in Nine California Counties
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“3), which is within the upper range of those reported in previous multicity studies in the United States (Franklin et al. 2007; Ostro et al. 2006; Schwartz et al. 1996; Zanobetti and Schwartz 2009).”
ResultInfluentialVisibility, air quality and daily mortality in Shanghai, China
Huang, W. Y., Tan, J., Kan, H., Zhao, N., Song, W., Song, G., Chen, G., Jiang, L., Jiang, C., Chen, R., et al. (2009) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2009.02.019 · Cited by 185
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“Ostro and Zeka reported an increased risk of mortality from exposure to PM in groups with lower educational level (Ostro et al., 2006, 2008; Zeka et al., 2006).”
BackgroundSource apportionment of PM2.5 in Beijing in 2004
Song, Y., Tang, X., Xie, S., Zhang, Y., Wei, Y., Zhang, M., Zeng, L., & Lü, S. (2006) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2006.11.058 · Cited by 162
“[3] B.”
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“Notwithstanding this, other studies were located in which mortality was likewise higher in the winter months (Ostro et al. 2006), with this being attributed to the different compositions displayed by particles in these two seasons.”
BackgroundEffect of air quality on assisted human reproduction
Legro, R. S., Sauer, M. V., Mottla, G. L., Richter, K. S., Li, X., Dodson, W. C., & Liao, D. (2010) · Human Reproduction · doi:10.1093/humrep/deq021 · Cited by 151
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Short-term exposures to PM2.5 and cause-specific mortality of cardiovascular health in China
Chen, C., Zhu, P., Li, L., Zhou, L., Liu, R., Sun, Q., Ban, J., Wang, W., Xu, D., & Li, T. (2017) · Environmental Research · doi:10.1016/j.envres.2017.10.046 · Cited by 151
“5 concentrations at below-guideline levels on human health and welfare have been made through a great deal of multi-center epidemiologic research in the United States, Europe, and other developed countries (Ostro et al., 2006; Franklin et al., 2007; Zanobetti and Schwartz, 2009; Atkinson et al., 2014).”
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“The piece-wise linear model is much more data-intensive and less precise (Suits et al., 1978; Ostro et al., 2006) than the polynomial ones; this is because a considerably lage number of ‘‘pieces’’ should be specified in order to approximate to the real relationship better and each ‘‘piece’’ requires a considerably lag…”
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“Meta analyses, recent large multi-city time-series and case-crossover studies, and general reviews of these studies are reported elsewhere (Anderson et al. 2005; Dominici et al. 2003a; Analitis et al. 2006; Klemm and Mason 2003; Franklin et al. 2007; Ostro et al. 2006; Zanobetti and Schwartz 2009; Samoli et al. 2008).”
BackgroundCardiovascular effects of particulate air pollution exposure: time course and underlying mechanisms
Langrish, J. P., Bosson, J. A., Unosson, J., Muala, A., Newby, D. E., Mills, N. L., Blomberg, A., & Sandström, T. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02566.x · Cited by 146
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“Several epidemiological studies have shown a positive association between the level of ambient particulate matter (PM) and mortality caused by respiratory and cardiovascular diseases [1,2].”
BackgroundEpidemiology of air pollution and diabetes
Thiering, E., & Heinrich, J. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.002 · Cited by 153
Fine particulate air pollution and daily mortality in Shenyang, China
Ma, Y., Chen, R., Pan, G., Xu, X., Song, W., Chen, B., & Kan, H. (2011) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2011.03.017 · Cited by 144
“However, compared with other studies in developed countries (COMEAP, 2006; Franklin et al., 2007; Klemm and Mason, 2003; Ostro et al., 2006; Ueda et al., 2009; Zanobetti and Schwartz, 2009), both Chinese studies reported relatively lower effect estimates per unit increase of PM2.”
ResultKamal, A., Cincinelli, A., Martellini, T., & Malik, R. N. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3748-0 · Cited by 144
“PAHs are capable of inducing mutation in human cells (Poirier 2004) and cardiovascular diseases (Ostro et al. 2006; Pope et al. 2002).”
BackgroundThe acute effects of fine particles on respiratory mortality and morbidity in Beijing, 2004–2009
Li, P., Xin, J., Wang, Y., Wang, S., Li, G., Pan, X., Liu, Z., & Wang, L. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1688-8 · Cited by 137
“9 cities in California Mortality Ostro et al. (2006) GAM 14–29 2.”
BackgroundExcess mortality in Europe following a future Laki-style Icelandic eruption
Schmidt, A., Ostro, B. D., Carslaw, K. S., Wilson, M., Thordarson, T., Mann, G. W., & Simmons, A. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108569108 · Cited by 140
Ostro, B. D., Feng, W.-Y., Broadwin, R., Malig, B. J., Green, R. S., & Lipsett, M. J. (2008) · Occupational and Environmental Medicine · doi:10.1136/oem.2007.036673 · Cited by 132
Lee, H., Honda, Y., Hashizume, M., Guo, Y. L., Wu, C., Kan, H., Jung, K., Lim, Y., Yi, S., & Kim, H. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.08.036 · Cited by 131
“5 reportedly has the greatest effect on human health (Kan et al., 2007; Ostro et al., 2006; Pope et al., 2002), more recent reports have indicated that PM10 2.”
BackgroundResultInfluentialAssociation of pollution and climate with atopic eczema in US children.
Kathuria, P., & Silverberg, J. I. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12543 · Cited by 127
“5 has been associated with adverse cardiovascular effects (17–19), respiratory effects (20–22), and all-cause mortality (23, 24).”
BackgroundParaskevopoulou, D., Liakakou, E., Gerasopoulos, E., & Mihalopoulos, N. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.04.022 · Cited by 126
“5) are of particular concern because of the significant contribution to detrimental health effects (Dockery and Pope, 1994; Ostro et al., 2006), since they act as carriers for toxicants and mutagenic components (Beddows et al., 2004) and, owing to their size, are able to penetrate cell membranes…”
BackgroundExposure to urban particulate matter and its association with human health risks
Alemayehu, Y. A., Leta, S., & Terfie, T. A. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-09132-1 · Cited by 131
Wehner, B., Birmili, W., Ditas, F., Wu, Z., Hu, M., Liu, X., Mao, J., Sugimoto, N., & Wiedensohler, A. (2008) · Atmospheric chemistry and physics · doi:10.5194/acp-8-6155-2008 · Cited by 122
“During the last decade more studies have targeted PM 2.5 (e.g., Schwartz and Naes, 2000; Franklin et al., 2006; Ostro et al., 2006).”
BackgroundInfluentialJiménez, E., Linares, C., Martínez, D., & Díaz, J. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.08.049 · Cited by 120
Characterization of fine particle emissions from incense burning
See, S. W., & Balasubramanian, R. (2010) · Building and Environment · doi:10.1016/j.buildenv.2010.11.006 · Cited by 118
Resuspension of Particulate Matter from Carpet Due to Human Activity
Rosati, J. A., Thornburg, J. W., & Rodes, C. E. (2008) · Aerosol Science and Technology · doi:10.1080/02786820802187069 · Cited by 122
“Studies have related fine PM (<2.5 µm) and daily mortality (Laden et al. 2000; Schwartz et al. 2002; Ostro et al. 2006).”
BackgroundInfluentialContini, D., Cesari, D., Genga, A., Siciliano, M., Ielpo, P., Guascito, M. R., & Conte, M. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.10.127 · Cited by 117
Olmo, N. R. S., Saldiva, P. H. N., Braga, A. L. F., Lin, C. A., Santos, U. D. P., & Pereira, L. A. A. (2011) · Clinics · doi:10.1590/s1807-59322011000400025 · Cited by 117
Air pollution and lung cancer incidence in China: Who are faced with a greater effect?
Guo, H., Chang, Z., Wu, J., & Li, W. (2019) · Environment International · doi:10.1016/j.envint.2019.105077 · Cited by 114
“, 2013), educational level (Jerrett et al., 2004; Ostro et al., 2005; Chen et al., 2012; Chen et al., 2017), employment (Jerrett et al.”
Kamal, A., Malik, R. N., Martellini, T., & Cincinelli, A. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.05.140 · Cited by 114
Transport pathways and potential sources of PM10 in Beijing
Zhu, L., Huang, X., Shi, H., Cai, X., & Song, Y. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.10.040 · Cited by 114
“Particulate matter with aerodynamic diameters smaller than 10 mm (PM10) was found to be harmful to human health (Schwartz et al., 1996; Ostro et al., 2006).”
BackgroundKim, J. H., & Hong, Y. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104406 · Cited by 114
Yang, C., Peng, X., Huang, W. Y., Chen, R., Xu, Z., Chen, B., & Kan, H. (2011) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-011-0707-7 · Cited by 112
“strongly associated with cardiorespiratory mortality than with all-cause mortality risk (Ostro et al. 2006; Stoelzel et al. 2007; Wichmann et al. 2000).”
BackgroundInfluentialSystematic review and metaanalysis of air pollution exposure and risk of diabetes
Janghorbani, M., Momeni, F., & Mansourian, M. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9907-2 · Cited by 111
“Some time-series and case-crossover studies have linked short-term exposure to air pollution with diabetes-related death [21, 23, 24], and data from prospective cohort studies of long-term exposure to air pollution and diabetes collectively indicate a weak association between traffic-related air pollution and the inci…”
BackgroundMethodIgnotti, E., Hacon, S. D. S., Junger, W. L., Mourão, D. S., Longo, K. M., Freitas, S. R., Artaxo, P. E., & de León, A. P. (2010) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2010000400017 · Cited by 111
Association of daily cause-specific mortality with ambient particle air pollution in Wuhan, China
Qian, Z. M., He, Q., Lin, H.-M., Kong, L., Liao, D., Dan, J., Bentley, C. M., & Wang, B. (2007) · Environmental Research · doi:10.1016/j.envres.2007.05.007 · Cited by 109
Berman, J. D., Ebisu, K., Peng, R. D., Dominici, F., & Bell, M. L. (2017) · The Lancet Planetary Health · doi:10.1016/s2542-5196(17)30002-5 · Cited by 114
Significance of PM2.5 Air Quality at the Indian Capital
Sahu, S. K., & Kota, S. H. (2016) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2016.06.0262 · Cited by 107
“This value lies in the range of global estimate by Atkinson et al. (2014), and closer to several studies in China (Dai et al. , 2004; Chen et al. , 2011) and the US (Ostro et al. , 2006).”
Theodosi, C., Tsagkaraki, M., Zarmpas, P., Grivas, G., Liakakou, E., Paraskevopoulou, D., Lianou, M., Gerasopoulos, E., & Mihalopoulos, N. (2018) · Atmospheric chemistry and physics · doi:10.5194/acp-18-14371-2018 · Cited by 114
“…2.5 µm or less are of particular interest due to the fact that they contribute significantly to detrimental health effects (Dockery and Pope, 1994; Ostro et al., 2006), penetrating the cell membranes more efficiently (Salma et al., 2002; Li et al., 2003; Bell et al., 2009) and acting as carriers…”
BackgroundInfluentialLi, P., Xin, J., Wang, Y., Li, G., Pan, X., Wang, S., Cheng, M., Wen, T., Wang, G., & Liu, Z. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3301-1 · Cited by 105
Chen, Z., Cui, L., Cui, X., Li, X., Yu, K., Yue, K., Dai, Z., Zhou, J., Jia, G., & Zhang, J. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.368 · Cited by 104
Chemical composition of PM2.5 during winter in Tianjin, China
Jin-xia, G., Bai, Z., Li, W., Wu, L., Liu, A., Dong, H., & Xie, Y. (2011) · Particuology · doi:10.1016/j.partic.2011.03.001 · Cited by 103
Shumake, K. L., Sacks, J. D., Lee, J. S., & Johns, D. O. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0001-5 · Cited by 102
Li, Y., Ma, Z., Zheng, C., & Shang, Y. (2015) · International Journal of Biometeorology · doi:10.1007/s00484-015-0984-z · Cited by 99
“5 has a stronger association with cardio-respiratory mortality risk than PM10 does (Schwartz and Neas 2000; Wilson and Suh 1997; Kan et al. 2007; Schwartz et al. 1996; Ostro et al. 2006; Stolzel et al. 2006).”
BackgroundRaaschou‐Nielsen, O., Sørensen, M., Ketzel, M., Hertel, O., Loft, S. H., Tjønneland, A. M., Overvad, K., & Andersen, Z. J. (2012) · Diabetologia · doi:10.1007/s00125-012-2698-7 · Cited by 98
“Finally, time-series [17, 18] and case-crossover studies [19] have linked short-term variations in air pollution with diabetes mortality.”
BackgroundAmbient PM2.5 Human Health Effects—Findings in China and Research Directions
Miller, L., & Xu, X. (2018) · Atmosphere · doi:10.3390/atmos9110424 · Cited by 98
Paraskevopoulou, D., Bougiatioti, A., Stavroulas, I., Fang, T., Lianou, M., Liakakou, E., Gerasopoulos, E., Weber, R. J., Nenes, A., & Mihalopoulos, N. (2019) · Atmospheric Environment · doi:10.1016/j.atmosenv.2019.02.027 · Cited by 96
Bølling, A. K., Totlandsdal, A. I., Låg, M., Refsnes, M., & Schwarze, P. E. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.10.014 · Cited by 95
Metadata
- Authors
- Ostro, B., Broadwin, R., Green, S., Feng, W.-Y., & Lipsett, M.
- Affiliations
- University of California, Davis (US)
- California Office of Environmental Health Hazard Assessment, Oakland, California, USA
- University of California, San Francisco (US)
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-09-01
- Volume
- 114
- Issue
- 1
- Pages
- 29-33
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC1332652
- OpenAlex
- W2058611314
- Cited by
- 425
- References
- 23
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 24 · 2022: 15 · 2021: 14 · 2020: 16 · 2019: 28 · 2018: 23 · 2017: 21 · 2016: 13 · 2015: 21 · 2014: 46 · 2013: 31 · 2012: 25
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 4502 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- PM2.5, air pollution, mortality, all-cause mortality, respiratory mortality, cardiovascular mortality, ischemic heart disease, diabetes mortality, subpopulation differences, California counties
- MeSH terms
- Air Pollutants, Air Pollution, California, Cause of Death, Dust, Environmental Monitoring, Female, Humans, Humidity, Male, Mortality, Particle Size, Temperature, Models, Statistical, Epidemiological Monitoring
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