The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
Open accessAbstract
BACKGROUND: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE: We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as reflected by maternal whole blood and plasma lead levels. METHODS: We measured lead in maternal plasma and whole blood during each trimester in 146 pregnant women in Mexico City. We then measured umbilical cord blood lead at delivery and, when offspring were 12 and 24 months of age, measured blood lead and administered the Bayley Scales of Infant Development. We used multivariate regression, adjusting for covariates and 24-month blood lead, to compare the impacts of our pregnancy measures of fetal lead dose. RESULTS: Maternal lead levels were moderately high with a first-trimester blood lead mean (+/- SD) value of 7.1 +/- 5.1 microg/dL and 14% of values >or=10 microg/dL. Both maternal plasma and whole blood lead during the first trimester (but not in the second or third trimester) were significant predictors (p < 0.05) of poorer Mental Development Index (MDI) scores. In models combining all three trimester measures and using standardized coefficients, the effect of first-trimester maternal plasma lead was somewhat greater than the effect of first-trimester maternal whole blood lead and substantially greater than the effects of second- or third-trimester plasma lead, and values averaged over all three trimesters. A 1-SD change in first-trimester plasma lead was associated with a reduction in MDI score of 3.5 points. Postnatal blood lead levels in the offspring were less strongly correlated with MDI scores. CONCLUSIONS: Fetal lead exposure has an adverse effect on neurodevelopment, with an effect that may be most pronounced during the first trimester and best captured by measuring lead in either maternal plasma or whole blood.
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Lanphear, B. P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D. C., Canfield, R. L., Dietrich, K. N., Bornschein, R., Greene, T., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7688 · Cited by 2,205
Self-citationIntellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter
Canfield, R. L., Henderson, C. R., Cory-Slechta, D. A., Cox, C., Jusko, T. A., & Lanphear, B. P. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022848 · Cited by 2,081
Cited by
Scientific Opinion on Lead in Food
(CONTAM), E. P. O. C. I. T. F. C. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1570 · Cited by 1,080
Neurotoxic Effects and Biomarkers of Lead Exposure: A Review
Sanders, T., Liu, Y., Buchner, V., & Tchounwou, P. B. (2009) · Reviews on Environmental Health · doi:10.1515/reveh.2009.24.1.15 · Cited by 1,076
Boskabady, M., Marefati, N., Farkhondeh, T., Shakeri, F., Farshbaf, A., & Boskabady, M. H. (2018) · Environment International · doi:10.1016/j.envint.2018.08.013 · Cited by 451
Recommendations for Medical Management of Adult Lead Exposure
Kosnett, M. J., Wedeen, R. P., Rothenberg, S. J., Hipkins, K. L., Materna, B. L., Schwartz, B. S., Hu, H., & Woolf, A. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9784 · Cited by 358
Self-citationHu, H., Shih, R., Rothenberg, S., & Schwartz, B. S. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9783 · Cited by 306
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Metadata
- Authors
- Hu, H., Téllez-Rojo, M. M., Bellinger, D., Smith, D., Ettinger, A. S., Lamadrid-Figueroa, H., Schwartz, J., Schnaas, L., Mercado-García, A., & Hernández-Avila, M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-11
- Volume
- 114
- Issue
- 11
- Pages
- 1730-1735
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2104800336
- Cited by
- 366
- References
- 2
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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